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Headshot of Investigator Ype Elgersma.
Headshot of Investigator Ype Elgersma.

Awardee

Ype Elgersma, Ph.D.

SFARI Investigator

SFARI Scientific Review Board

Affiliations
  • Professor, Erasmus University Medical Center

Publications

De novo variants in the PSMC3 proteasome AAA-ATPase subunit gene cause neurodevelopmental disorders associated with type I interferonopathies.

medRxiv, December 7, 2021

Ebstein F., Küry S., Most V., Rosenfelt C., Scott-Boyer M.-P., van Woerden G.M., et al.

Adult Ube3a gene reinstatement restores the electrophysiological deficits of prefrontal cortex layer 5 neurons in a mouse model of Angelman syndrome.

J. Neurosci., September 11, 2018

Rotaru D.C., van Woerden G.M., Wallaard I., and Y. Elgersma

UBE3A loss increases excitability and blunts orientation tuning in the visual cortex of Angelman syndrome model mice.

J. Neurophysiol., June 30, 2017

Wallace M.L., van Woerden G.M., Y. Elgersma, Smith S.L., and B. Philpot

GABAergic neuron-specific loss of UBE3A causes Angelman syndrome-like EEG abnormalities and enhances seizure susceptibility.

Neuron, April 5, 2016

Judson M.C., M. Wallace, Sidorov M.S., Burette A.C., Gu B., van Woerden G.M., et al.

Projects

Circuits Image

The role of UBE3A in autism: Is there a critical window for social development?

Awarded 2013

Featuring Ype Elgersma

Image of neurons

SFARI 2021 Pilot Awardees Announced

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Simons Foundation Autism Research Initiative (SFARI)

SFARI is the Simons Foundation’s autism research program, advancing the basic science of autism and related neurodevelopmental disorders through funding, collaboration, and open science.

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