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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  1. Thalamus drives vocal onsets in the zebra finch courtship song

    Nature, March 23, 2023

    FW Moll, D Kranz, A Corredera Asensio, M Elmaleh, LA Ackert-Smith, and M. Long

  2. Catalyzing next-generation Artificial Intelligence through NeuroAI

    Nat Commun, March 23, 2023

    A. Zador, S Escola, B Richards, B Ölveczky, Y Bengio, K Boahen, et al.

  3. Interactions of genetic risks for autism and the broad autism phenotypes.

    Front. Psychiatry, March 21, 2023

    Dong L., Wang Y., Wang X., Luo T., Zhou Q., Zhao G., et al.

  4. Cell type-specific interpretation of noncoding variants using deep learning-based methods.

    Gigascience, March 20, 2023

    Sindeeva M., Chekanov N., Avetisian M., Shashkova T.I., Baranov N., Malkin E., et al.

  5. Applying the Metallicity-dependent Binary Fraction to Double White Dwarf Formation: Implications for LISA

    APJ, arXiv:2111.13700, March 20, 2023

    Sarah Thiele, K. Breivik, R. Sanderson, and Rodrigo Luger

  6. Prospective search time estimates reveal the strengths and limits of internal models of visual search

    J Exp Psychol Gen, March 20, 2023

    M Mazor, M Siegel, and J. Tenenbaum

  7. A novel SMARCC1-mutant BAFopathy implicates epigenetic dysregulation of neural progenitors in hydrocephalus.

    medRxiv, March 20, 2023

    Singh A.K., Viviano S., Allington G., McGee S., Kiziltug E., Mekbib K.Y., et al.

  8. The fluidic memristor: collective phenomena in elastohydrodynamic networks

    bioRxiv, March 19, 2023

    Alejandro Martinez-Calvo, et al.

  9. Neuron cilia constrain glial regulators to microdomains around distal neurons.

    bioRxiv, March 19, 2023

    Ray S., Gurung P., Manning R.S., Kravchuk A., and A. Singhvi

  10. Augmenting astrophysical scaling relations with machine learning: application to reducing the Sunyaev-Zeldovich flux-mass scatter

    PNAS, arXiv:2201.01305, March 17, 2023

    Digvijay Wadekar, Leander Thiele, F. Villaescusa-Navarro, J. Hill, M. Cranmer, D. Spergel, et al.

  11. Mechanisms of Dominant Electrophysiological Features of Four Subtypes of Layer 1 Interneurons

    J Neurosci, March 17, 2023

    JH Meng, B Schuman, B Ruby, and X. Wang

  12. An optical design enabling lightweight and large field-of-view head-mounted microscopes

    Nat Methods, March 17, 2023

    JR Scherrer, GF Lynch, JJ Zhang, and M. Fee

  13. Cnih3 deletion dysregulates dorsal hippocampal transcription across the estrous cycle.

    eNeuro, March 17, 2023

    Mulvey B., Frye H.E., Lintz T., Fass S., Tycksen E., Nelson E.C., et al.

  14. Molecular basis of polyglutamine-modulated ELF3 aggregation in Arabidopsis temperature response

    bioRxiv, March 16, 2023

    J. Lindsay, Philip A. Wigge, and S. Hanson

  15. Neural learning rules for generating flexible predictions and computing the successor representation

    Elife, March 16, 2023

    C Fang, D Aronov, L. Abbott, and EL Mackevicius

  16. Fast and sensitive GCaMP calcium indicators for imaging neural populations

    Nature, March 16, 2023

    Y Zhang, M Rózsa, Y Liang, D Bushey, Z Wei, J Zheng, et al.

  17. A Bregman-Kaczmarz method for nonlinear systems of equations

    arXiv:2303.08549, March 15, 2023

    R. Gower, Dirk A. Lorenz, and Maximilian Winkler

  18. Fastest-ever calcium sensors broaden the potential of neuronal imaging

    Nature, March 15, 2023

    MB Ryan, A. Churchland, Y Gong, and C Baker

  19. Astrophysics with the Laser Interferometer Space Antenna

    Living Reviews in Relativity, arXiv:2203.06016, March 14, 2023

    Pau Amaro Seoane, et al.

  20. Neural circuits underlying habituation of visually evoked escape behaviors in larval zebrafish

    Elife, March 14, 2023

    H Fotowat and F. Engert

  21. Stochastic phenotypes in RAS-dependent developmental diseases

    Current Biology, March 13, 2023

    Robert A. Marmion, et al.

  22. Dynamics of an incoherent feedforward loop drive ERK-dependent pattern formation in the early Drosophila embryo

    Development, 2023.03.09.531972, March 10, 2023

    Emily K. Ho, et al.

  23. The neural architecture of theory-based reinforcement learning

    Neuron, March 10, 2023

    MS Tomov, PA Tsividis, T Pouncy, J. Tenenbaum, and SJ Gershman

  24. Mechanism of KMT5B haploinsufficiency in neurodevelopment in humans and mice.

    Sci. Adv., March 10, 2023

    Sheppard S.E., Bryant L., Wickramasekara R.N., Vaccaro C., Robertson B., Hallgren J., et al.

  25. A complete biomechanical model of Hydra contractile behaviors, from neural drive to muscle to movement.

    Proc Natl Acad Sci USA, March 10, 2023

    H Wang, J Swore, S Sharma, JR Szymanski, R Yuste, TL Daniel, et al.

  26. Evolutionary history of MEK1 illuminates the nature of cancer and RASopathy mutations

    bioRxiv, March 9, 2023

    Ekaterina P. Andrianova, Robert A. Marmion, S. Shvartsman, and Igor B. Zhulin

  27. Spindle dynamics and orientation depends in forge generators configuration

    Bulletin of the American Physical Society, March 8, 2023

    Vicente J Gomez Herrera, M. Shelley, R. Farhadifar, D. Needleman, and Maya Anjur-Dietrich

  28. A screen for MeCP2-TBL1 interaction inhibitors using a luminescence-based assay.

    Sci. Rep., March 8, 2023

    Alexander-Howden B., Zhang L., van der Sloot A.M., Tollis S., St-Cyr D.J., Sicheri F., et al.

  29. Multi-ancestry phenome-wide association of complement component 4 variation with psychiatric and brain phenotypes in youth.

    Genome Biol., March 7, 2023

    L. Hernandez, Kim M., Zhang P., Bethlehem R.A.I., Hoftman G., Loughnan R., et al.

  30. Evolution of neural activity in circuits bridging sensory and abstract knowledge

    Elife, March 7, 2023

    F Mastrogiuseppe, N Hiratani, and P. Latham

  31. Neuron-specific transcriptomic signatures indicate neuroinflammation and altered neuronal activity in ASD temporal cortex.

    Proc. Natl. Acad. Sci. U. S. A., March 7, 2023

    Zhang P., Omanska A., Ander B.P., M. Gandal, Stamova B., and Schumann C.M.

  32. Early impairments of visually-driven neuronal ensemble dynamics in the rTg4510 tauopathy mouse model

    Neurobiol Dis, March 3, 2023

    A Parka, C Degel, J Dreyer, U Richter, B Hall, JF Bastlund, et al.

  33. A response to claims of emergent intelligence and sentience in a dish

    Neuron, March 2, 2023

    F Balci, S Ben Hamed, T Boraud, S Bouret, T Brochier, C Brun, et al.

  34. A modular architecture for organizing, processing and sharing neurophysiology data

    Nat Methods, March 2, 2023

    International Brain Laboratory, N Bonacchi, GA Chapuis, A. Churchland, EEJ DeWitt, M Faulkner, et al.

  35. Fine motor skill and expressive language in minimally verbal and verbal school-aged autistic children.

    Autism Res., March 1, 2023

    Butler L.K. and H. Tager-Flusberg

  36. Electronic Descriptors for Supervised Spectroscopic Predictions

    arxiv:2205.12074, March 1, 2023

    A. Rubio

  37. Floquet band engineering in action

    arxiv:, March 1, 2023

    A. Rubio

  38. Attosecond magnetization dynamics in non-magnetic materials driven by intense femtosecond lasers

    arxiv:2207.06711, March 1, 2023

    A. Rubio

  39. Ion filling of a one-dimensional nanofluidic channel in the interaction confinement regime

    arxiv:2301.04622, March 1, 2023

    N. Kavokine

  40. Solving 2D and 3D lattice models of correlated fermions -- combining matrix product states with mean field theory

    arxiv:2207.03754, March 1, 2023

    H. Shi, H. Shi, and S. Zhang

  41. Fast quantum circuit cutting with randomized measurements

    arxiv:2207.14734, March 1, 2023

  42. Catalyzing next-generation [Artificial Intelligence} through {NeuroAI}

    Nature Communications, 2023

    A Zador, S Escola, B Richards, B Ölveczky, Y Bengio, K Baohen, et al.

  43. Catalyzing next-generation Artificial Intelligence through NeuroAI

    Nature Communications, 2023

    Anthony Zador, Sean Escola, Blake Richards, Bence Ölveczky, Yoshua Bengio, Kwabena Boahen, et al.

  44. Polar prediction of natural videos

    arXiv:2303.03432, 2023

    P. Fiquet and E. Simoncelli

  45. Quantum electrodynamics of chiral and antichiral waveguide arrays

    Optics Letters, arXiv:2210.04082, March 1, 2023

    Jeremy G. Hoskins, M. Rachh, and John C. Schotland

  46. Altered dendritic morphology in dorsolateral prefrontal cortex of nonhuman primates prenatally exposed to maternal immune activation.

    Brain Behav. Immun., March 1, 2023

    Hanson K.L., Weir R.K., Iosif A.M., Van de Water J., Carter S.C., K. McAllister, et al.

  47. Identifying phenotypic and physiological subgroups of preschoolers with autism spectrum disorder.

    Psychol. Med., March 1, 2023

    Bazelmans T., E. Jones, Ghods S., Corrigan S., Toth K., T. Charman, et al.

  48. Contrast and Luminance Gain Control in the Macaque's Lateral Geniculate Nucleus

    eNeuro, March 1, 2023

    RT Raghavan, JG Kelly, JM Hasse, PG Levy, MJ Hawken, and J. Movshon

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