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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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  1. Overexpression of CD47 is associated with brain overgrowth and 16p11.2 deletion syndrome.

    Proc. Natl. Acad. Sci. U. S. A., April 11, 2021

    J. Li, Brickler T., Banuelos A., Marjon K., Shcherbina A., Banerjee S., et al.

  2. Assessment of medical morbidities in a rhesus monkey model of naturally occurring low sociality.

    Autism Res., April 10, 2021

    Myers A.K., Talbot C.F., Rosso L.A.D., Maness A.C., Simmons S.M.V., Garner J.P., et al.

  3. Neural Anatomy and Optical Microscopy (NAOMi) Simulation for evaluating calcium imaging methods

    J Neurosci Methods, April 8, 2021

    A Song, JL Gauthier, J. Pillow, D. Tank, and AS Charles

  4. A cross-species neural integration of gravity for motor optimization

    Sci Adv., April 7, 2021

    J Gaveau, S Grospretre, B Berret, D. Angelaki, and C Papaxanthis

  5. deepregression: a Flexible Neural Network Framework for Semi-Structured Deep Distributional Regression

    arxiv:2104.02705, April 6, 2021

    David Rügamer, Ruolin Shen, Christina Bukas, Dominik Thalmeier, Nadja Klein, Chris Kolb, et al.

  6. Ab initio Full Cell GW+DMFT for Correlated Materials

    Phys. Rev. X, arXiv:2003.01349, April 6, 2021

    T. Zhu and G. Chan

  7. Genotype and defects in microtubule-based motility correlate with clinical severity in KIF1A-associated neurological disorder.

    HGG Adv., April 6, 2021

    Boyle L., Rao L., Kaur S., Fan X., Mebane C., Hamm L., et al.

  8. Diagnostic classification and prognostic prediction using common genetic variants in autism spectrum disorder: Genotype-based deep learning.

    JMIR Med. Inform, April 6, 2021

    Wang H. and Avillach P.

  9. Autism spectrum disorders classification using genotype data: A deep learning-based predictive classifier.

    JMIR Med. Inform., April 6, 2021

    Wang H. and Avillach P.

  10. High-fidelity estimates of spikes and subthreshold waveforms from 1-photon voltage imaging in vivo

    Cell Rep., April 6, 2021

    ME Xie, Y Adam, LZ Fan, UL Böhm, I Kinsella, D Zhou, et al.

  11. Classification of Magnetohydrodynamic Simulations Using Wavelet Scattering Transforms

    APJ, arXiv:2010.11963, April 5, 2021

    Andrew K. Saydjari, et al.

  12. Comment on “Stepped pressure profile equilibria in cylindrical plasmas via partial Taylor relaxation” [J. Plasma Physics (2006), vol. 72, part 6, pp. 1167–1171]

    Journal of Plasma Physics, 2021

    Yuanfan Wang, D. Malhotra, and Antoine J. Cerfon

  13. Synaptic plasticity as Bayesian inference

    Nat Neurosci., April 5, 2021

    L Aitchison, J Jegminat, JA Menendez, JP Pfister, A. Pouget, and P. Latham

  14. Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks

    bioRxiv 2021.04.04.438423, April 5, 2021

    J. Koehler Leman, et al.

  15. Microglia complement signaling promotes neuronal elimination and normal brain functional connectivity.

    bioRxiv, April 2, 2021

    Deivasigamani S., Miteva M.T., Natale S., Gutierrez-Barragan D., Basilico B., Di Angelantonio S., et al.

  16. Constrained non-negative matrix factorization enabling real-time insights of in situ and high-throughput experiments

    arXiv:2104.00864v1, April 2, 2021

    M. Maffettone, A. Daly, and D. Olds

  17. Measuring depression in autistic adults: Psychometric validation of the Beck Depression Inventory-II.

    Assessment, April 1, 2021

    Williams Z.J., Everaert J., and Gotham K.O.

  18. An Implicit Finite Volume Scheme to Solve the Time-dependent Radiation Transport Equation Based on Discrete Ordinates

    APJS, arXiv:2102.02212, April 1, 2021

    Y. Jiang

  19. Spontaneous neural activity relates to psychiatric traits in 16p11.2 CNV carriers: An analysis of EEG spectral power and multiscale entropy.

    J. Psychiatr. Res., April 1, 2021

    Al-Jawahiri R., Jones M., and Milne E.

  20. Comparison of Full-Reference Image Quality Models for Optimization of Image Processing Systems

    International Journal of Computer Vision, arxiv:https://arxiv.org/pdf/2005.01338.pdf, April 1, 2021

    Keyan Ding, Kede Ma, Shiqi Wang, and E. Simoncelli

  21. Fast periodic Gaussian density fitting by range separation

    arxiv:2102.02989, April 1, 2021

    Hong-Zhou Ye and Timothy C. Berkelbach

  22. Filling anomaly for general 2D and 3D C

    arxiv:, April 1, 2021

    Yuan Fang and J. Cano

  23. Improving scalability in systems neuroscience

    Neuron, April 1, 2021

    ZS Chen and B. Pesaran

  24. Computation of the electroencephalogram (EEG) from network models of point neurons.

    PloS Comput. Biol., April 1, 2021

    Martínez-Cañada P., Ness T.V., Einevoll G.T., Fellin T., and S. Panzeri

  25. Flexible scaling and persistence of social vocal communication

    Nature, March 31, 2021

    J Chen, JE Markowitz, V Lilascharoen, S Taylor, P Sheurpukdi, JA Keller, et al.

  26. Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues

    Cell Rep., March 31, 2021

    MB Chen, AC Yang, H Yousef, D Lee, W Chen, N Schaum, et al.

  27. Multivariate genome-wide analysis of education, socioeconomic status and brain phenome.

    Nat. Hum. Behav., March 31, 2021

    Wendt F.R., Pathak G.A., Lencz T., Krystal J.H., Gelernter J., and R. Polimanti

  28. De novo structural mutation rates and gamete-of-origin biases revealed through genome sequencing of 2,396 families.

    Am. J. Hum. Genet., March 31, 2021

    Belyeu J.R., Brand H., Wang H., Zhao X., Pedersen B.S., Feusier J., et al.

  29. Autism BrainNet.

    Arch. Pathol. Lab. Med., March 31, 2021

    M. Anderson, Quinton R., Kelly K., Falzon A., Halladay A., Schumann C.M., et al.

  30. Stellar Evolution in AGN Disks

    The Astrophysical Journal, March 30, 2021

    M. Cantiello, A. Jermyn, and D. N. C. Lin

  31. 3DeeCellTracker, a deep learning-based pipeline for segmenting and tracking cells in 3D time lapse images

    Elife, March 30, 2021

    C Wen, T Miura, V Voleti, K Yamaguchi, M Tsutsumi, K Yamamoto, et al.

  32. MTSplice predicts effects of genetic variants on tissue-specific splicing.

    Genome Biol., March 30, 2021

    Cheng J., Çelik M.H., Kundaje A., and Gagneur J.

  33. Comparison of explicit and mean-field models of cytoskeletal filaments with crosslinking motors

    The European Physical Journal E, March 29, 2021

    A. Lamson, J. Moore, F. Fang, M. Glaser, M. Shelley, and M. Betterton

  34. Learning is shaped by abrupt changes in neural engagement

    Nat Neurosci, March 29, 2021

    JA Hennig, EF Oby, MD Golub, LA Bahureksa, PT Sadtler, KM Quick, et al.

  35. Combining Brain Perturbation and Neuroimaging in Non-human Primates

    Neuroimage, March 29, 2021

    PC Klink, JF Aubry, VP Ferrera, AS Fox, S Froudist-Walsh, B Jarraya, et al.

  36. A biologically plausible neural network for multi-channel Canonical Correlation Analysis

    MIT Direct, 2021

    D. Lipshutz, Y. Bahroun, S. Golkar, A. Sengupta, and D. Chklovskii

  37. Fast computation of latent correlations

    Journal of Computational and Graphical Statistics, arxiv:2006.13875, March 29, 2021

    Grace Yoon, C. Müller, and Irina Gaynanova

  38. The many behaviors of deformable active droplets

    Mathematical Biosciences and Engineering, March 25, 2021

    Y-N. Young, M. Shelley, and D. Stein

  39. The connectome predicts resting-state functional connectivity across the Drosophila brain

    Curr Biol, March 23, 2021

    MH Turner, K Mann, and T. Clandinin

  40. Tracking the Footprints of Spin Fluctuations: A Multi-Method, Multi-Messenger Study of the Two-Dimensional Hubbard Model

    Phys. Rev. X, arxiv:2006.10769, 2021

    Thomas Schäfer, N. Wentzell, Fedor Šimkovic IV, Y. He, Cornelia Hille, Marcel Klett, et al.

  41. Experience-dependent contextual codes in the hippocampus

    Nat Neurosci, March 22, 2021

    MH Plitt and L. Giocomo

  42. Prefrontal cortex represents heuristics that shape choice bias and its integration into future behavior

    Curr Biol, March 22, 2021

    G Mochol, R. Kiani, and R Moreno-Bote

  43. Directed information exchange between cortical layers in macaque V1 and V4 and its modulation by selective attention.

    Proc. Natl. Acad. Sci. U. S. A., March 22, 2021

    Ferro D., van Kempen J., Boyd M., S. Panzeri, and Thiele A.

  44. Exponential-family embedding with application to cell developmental trajectories for single-cell RNA-seq data.

    J. Am. Stat. Assoc., March 21, 2021

    Lin K.Z., Lei J., and K. Roeder

  45. Glia actively sculpt sensory neurons by controlled phagocytosis to tune animal behavior.

    Elife, March 20, 2021

    Raiders S., Black E.C., Bae A., MacFarlane S., Klein M., Shaham S., et al.

  46. A Gravitational-wave Measurement of the Hubble Constant Following the Second Observing Run of Advanced LIGO and Virgo

    APJ, arXiv:1908.06060, March 19, 2021

    The LIGO Scientific Collaboration, et al.

  47. Nonequilibrium Green's Functions for Functional Connectivity in the Brain

    Phys Rev Lett, March 19, 2021

    Francesco Randi and A. Leifer

  48. Evaluation of UBE3A antibodies in mice and human cerebral organoids.

    Sci Rep, March 17, 2021

    Sen D., Drobna Z., and A. Keung

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