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  1. Catalyzing next-generation Artificial Intelligence through NeuroAI

    Publication

  2. Next-generation brain observatories

    Publication

  3. The application of artificial intelligence to biology and neuroscience

    Publication
    Over the last decade, the artificial intelligence (AI) has undergone a revolution that is poised to transform the economy, society, and science. The pace of progress is staggering …

  4. Cellular anatomy of the mouse primary motor cortex

    Publication
    An essential step toward understanding brain function is to establish a structural framework with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and systems can …

  5. Standardized and reproducible measurement of decision-making in mice

    Publication
    Progress in science requires standardized assays whose results can be readily shared, compared, and reproduced across laboratories. Reproducibility, however, has been a concern in neuroscience, particularly for measurements …

  6. BARcode DEmixing through Non-negative Spatial Regression (BarDensr)

    Publication
    Modern spatial transcriptomics methods can target thousands of different types of RNA transcripts in a single slice of tissue. Many biological applications demand a high spatial density of …

  7. BRICseq Bridges Brain-wide Interregional Connectivity to Neural Activity and Gene Expression in Single Animals.

    Publication
    Comprehensive analysis of neuronal networks requires brain-wide measurement of connectivity, activity, and gene expression. Although high-throughput methods are available for mapping brain-wide activity and transcriptomes …

  8. High-Throughput Mapping of Long-Range Neuronal Projection Using In Situ Sequencing.

    Publication
    Understanding neural circuits requires deciphering interactions among myriad cell types defined by spatial organization, connectivity, gene expression, and other properties. Resolving these cell types requires both single-neuron …

  9. A critique of pure learning and what artificial neural networks can learn from animal brains

    Publication
    Artificial neural networks (ANNs) have undergone a revolution, catalyzed by better supervised learning algorithms. However, in stark contrast to young animals (including humans), training such networks requires enormous …

  10. Network cloning using DNA barcodes.

    Publication
    The connections between neurons determine the computations performed by both artificial and biological neural networks. Recently, we have proposed SYNSeq, a method for converting the connectivity of a …

  11. Cellular barcoding: lineage tracing, screening and beyond.

    Publication
    Cellular barcoding is a technique in which individual cells are labeled with unique nucleic acid sequences, termed barcodes, so that they can be tracked through space and time …

  12. The logic of single-cell projections from visual cortex.

    Publication
    Neocortical areas communicate through extensive axonal projections, but the logic of information transfer remains poorly understood, because the projections of individual neurons have not been systematically characterized. It …

  13. Efficient in situ barcode sequencing using padlock probe-based BaristaSeq.

    Publication
    Cellular DNA/RNA tags (barcodes) allow for multiplexed cell lineage tracing and neuronal projection mapping with cellular resolution. Conventional approaches to reading out cellular barcodes trade off spatial …