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  • Bringing people and ideas together to fund, conduct, and share transformative science.

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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. SFARI Sex Differences Collaboration Gathers for Third Annual Meeting

    April 23, 2025
    On January 27–28, the Simons Foundation held the third annual meeting of the SFARI Sex Differences Collaboration (SSDC). Formed in 2021, this collaboration seeks to understand the …
  2. Oxytocin Regulates Changes in Social Brain Circuits Connectivity in a Cntnap2 Mouse Model of Autism

    July 1, 2022
    Daniel Geschwind and colleagues showed that Cntnap2 knockout mice exhibit alterations in brain-wide connectivity related to social behaviors and that oxytocin within the nucleus accumbens regulates changes …
  3. Analysis of Autism BrainNet Postmortem Brain Tissue RFA: Awardees Announced

    June 30, 2022
    SFARI is pleased to announce that it intends to fund four grants in response to the request for applications (RFA) focused on the analysis of postmortem brain tissue …
  4. 2020 SFARI Collaboration on Sex Differences in Autism Awardees Announced

    July 29, 2021
    SFARI is pleased to announce that it intends to fund five collaborative groups in response to the 2020 SFARI Collaboration on Sex Differences in Autism request for applications.
  5. SFARI Winter 2020 Pilot Awardees Announced

    March 26, 2020
    SFARI is pleased to announce that it intends to fund 11 grants in response to the Winter 2020 Pilot Award request for applications.
  6. Allelic Imbalance in ASD-Associated Gene Expression

    November 18, 2019
    Daniel Geschwind, Michael Gandal and colleagues reported that allelic imbalance in gene expression in ASD shows a surprising preference for the minor allele and implicates a family of …
  7. SFARI Fall 2018 Science Meeting Highlighted Recent Findings in Autism Research

    May 30, 2019
    SFARI held its fourteenth science meeting September 30–October 2, 2018. SFARI investigators, collaborators and foundation staff came together to discuss recent findings in autism genetics, molecular and …
  8. Shared Alterations in Gene Expression Networks Mirror Genetic Risk Across Neuropsychiatric Disorders

    February 23, 2018
    In comparing gene expression profiles and SNP risk across psychiatric disorders, Michael Gandal, Daniel Geschwind and colleagues found that shared genetic risk manifests in alterations in gene networks.

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