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  • Bringing people and ideas together to fund, conduct, and share transformative science.

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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

  • All News
  • Research News
  • Funding Announcements
  • Newsletter Sign Up
  • Press Releases
  • Media Relations

We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

  • Events Calendar
  • Public Events
  • Presidential Lectures
  • Presents
  • Flatiron Events
  • Past Events

Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

  • All Open Positions
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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  • Simons Collaboration on Localization of Waves
  • Simons Collaboration on Plasticity and the Aging Brain
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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Processing of social and monetary rewards in autism spectrum disorders.

    Publication
  2. Patterns of connectome variability in autism across five functional activation tasks. Findings from the leap project.

    Publication
  3. Cerebellar atypicalities in autism?

    Publication
  4. Social attention in anorexia nervosa and autism spectrum disorder: Role of social motivation.

    Publication
  5. Autism is associated with interindividual variations of gray and white matter morphology.

    Publication
  6. Evaluation of data imputation strategies in complex, deeply-phenotyped data sets: The case of the EU-AIMS Longitudinal European Autism Project.

    Publication
  7. Resting state EEG power spectrum and functional connectivity in autism: A cross-sectional analysis.

    Publication
  8. Fine-grained topographic organization within somatosensory cortex during resting-state and emotional face-matching task and its association with ASD traits.

    Publication
  9. The link between autism and sex-specific neuroanatomy, and associated cognition and gene expression.

    Publication
  10. Connectome-wide mega-analysis reveals robust patterns of atypical functional connectivity in autism.

    Publication
  11. GABAB receptor modulation of visual sensory processing in adults with and without autism spectrum disorder.

    Publication
  12. Excitatory/inhibitory imbalance in autism: The role of glutamate and GABA gene-sets in symptoms and cortical brain structure.

    Publication
  13. Preference for biological motion is reduced in ASD: Implications for clinical trials and the search for biomarkers.

    Publication
  14. The meaning of significant mean group differences for biomarker discovery.

    Publication
  15. A phase II randomized, double-blind, placebo-controlled study of the efficacy, safety, and tolerability of arbaclofen administered for the treatment of social function in children and adolescents with autism spectrum disorders: Study protocol for AIMS-2-TRIALS-CT1.

    Publication
  16. Imputing the number of responders from the mean and standard deviation of CGI-Improvement in clinical trials investigating medications for autism spectrum disorder.

    Publication
  17. Modulation of striatal functional connectivity differences in adults with and without autism spectrum disorder in a single-dose randomized trial of cannabidivarin.

    Publication
  18. Autism symptoms in anorexia nervosa: A comparative study with females with autism spectrum disorder.

    Publication
  19. Differences in social brain function in autism spectrum disorder are linked to the serotonin transporter.

    Publication
  20. COVID-19 health and social care access for autistic people: European policy review.

    Publication
  21. Imbalanced social-communicative and restricted repetitive behavior subtypes of autism spectrum disorder exhibit different neural circuitry.

    Publication
  22. Towards robust and replicable sex differences in the intrinsic brain function of autism.

    Publication
  23. Serotonin differentially modulates the temporal dynamics of the limbic response to facial emotions in male adults with and without autism spectrum disorder (ASD): A randomised placebo-controlled single-dose crossover trial.

    Publication
  24. Fractionating autism based on neuroanatomical normative modeling.

    Publication
  25. Modeling flexible behavior in childhood to adulthood shows age-dependent learning mechanisms and less optimal learning in autism in each age group.

    Publication
  26. Alexithymia in autism: Cross-sectional and longitudinal associations with social-communication difficulties, anxiety and depression symptoms.

    Publication
  27. Dissecting the phenotypic heterogeneity in sensory features in autism spectrum disorder: A factor mixture modelling approach.

    Publication
  28. Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women.

    Publication
  29. Large-scale analyses of the relationship between sex, age and intelligence quotient heterogeneity and cortical morphometry in autism spectrum disorder.

    Publication
  30. Cortical responses before 6 months of life associate with later autism.

    Publication
  31. Atypical processing of voice sounds in infants at risk for autism spectrum disorder.

    Publication
  32. Coregistering functional near-infrared spectroscopy with underlying cortical areas in infants.

    Publication
  33. Reduced neural sensitivity to social stimuli in infants at risk for autism.

    Publication

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