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  • Bringing people and ideas together to fund, conduct, and share transformative science.

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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Fixational eye movements enhance the precision of visual information transmitted by the primate retina

    Publication
    Fixational eye movements alter the number and timing of spikes transmitted from the retina to the brain, but whether these changes enhance or degrade the retinal signal is …
  2. Nonlinear Decoding of Natural Images From Large-Scale Primate Retinal Ganglion Recordings

    Publication
    Decoding sensory stimuli from neural activity can provide insight into how the nervous system might interpret the physical environment, and facilitates the development of brain-machine interfaces. Nevertheless …
  3. Reconstruction of natural images from responses of primate retinal ganglion cells

    Publication
    The visual message conveyed by a retinal ganglion cell (RGC) is often summarized by its spatial receptive field, but in principle also depends on the responses of other …
  4. Massively parallel microwire arrays integrated with CMOS chips for neural recording.

    Publication
    Multi-channel electrical recordings of neural activity in the brain is an increasingly powerful method revealing new aspects of neural communication, computation, and prosthetics. However, while planar silicon …
  5. Inference of nonlinear receptive field subunits with spike-triggered clustering.

    Publication
  6. A Data-Compressive Wired-OR Readout for Massively Parallel Neural Recording.

    Publication
    Neural interfaces of the future will be used to help restore lost sensory, motor, and other capabilities. However, realizing this futuristic promise requires a major leap forward in …
  7. Unusual Physiological Properties of Smooth Monostratified Ganglion Cell Types in Primate Retina.

    Publication
    The functions of the diverse retinal ganglion cell types in primates and the parallel visual pathways they initiate remain poorly understood. Here, unusual physiological and computational properties of …
  8. Pathway-specific asymmetries between ON and OFF visual signals.

    Publication
    … diverse ON and OFF signaling pathways.
  9. Electrical stimulus artifact cancellation and neural spike detection on large multi-electrode arrays.

    Publication
    Simultaneous electrical stimulation and recording using multi-electrode arrays can provide a valuable technique for studying circuit connectivity and engineering neural interfaces. However, interpreting these measurements is challenging …

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