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SFARI hosted a virtual workshop on March 14 and 18, 2022, to discuss the best practices for the development and use of induced pluripotent stem (iPS) cell models …

Ian Lipkin, Mady Hornig and colleagues showed that levels of immune molecules in mothers during pregnancy and in cord blood at birth are highly predictive of later autism …

SFARI Investigator Susanne Schmid and colleagues showed that loss of Cntnap2 in rats leads to immature-like delays in auditory cortex sound processing and overactive auditory neurons.

Ivan Iossifov, Michael Wigler and colleagues provided a detailed comparison of simplex and multiplex families with autism, supporting the view that de novo mutations are a more frequent …

SFARI Investigators Lilia Iakoucheva and Alysson Muotri and colleagues utilized 3D organoid brain cultures to demonstrate how defects in neuron migration are affected in 16p11.2 deletion and …

SFARI Investigator Bruce Herring and colleagues showed that ASD-linked mutations in Trio and NLGN1 cause deficits in synapse development and function.

Hisashi Umemori and colleagues showed that X-inactivation-based patchy expression of PCDH19 causes defects in presynaptic development and signaling in the mouse hippocampus, affecting memory processes.

The Bridge to Independence Award program serves as an overall scientific support system to help early-career scientists successfully launch their independent research positions. Fellows receive a commitment …

Bence Ölveczky, Jesse Marshall and colleagues developed a new method, CAPTURE, for long-term behavioral tracking in rodents and demonstrate its utility in tracking behaviors in Fmr1-KO …

Steven Hyman discusses the use of disease model systems to study neuropsychiatric and neurodevelopmental conditions, highlighting their benefits and limitations, and stressing the importance of knowing what questions …

Simon Chen and colleagues found that a reduction in locus-coeruleus noradrenaline neuromodulatory signaling contributes to altered motor learning in 16p11.2 deletion mice.

Lilia Iakoucheva and colleagues found that mice lacking a copy of the high-confidence ASD risk gene Cul3 have reduced brain volumes, potentially due to defects in Rho …

Jun Huh and colleagues found that maternal immune responses to infection may at least partially explain sex-specific differences in autism risk.

A recent study has uncovered new ASD inherited genetic risk variants. Over of the 50 percent of the genetic data used in the study came from SPARK.

Michael Platt and colleagues found that monkeys create complex internal representations of social situations and uncovered neural circuitry supporting social cooperation.

SFARI consultant-in-residence Gaspar Taroncher-Oldenburg discusses his work and collaboration with the Simons Foundation Flatiron Institute to study the microbiome and its potential implications for ASD …

J. Elliott Robinson talks about his lab’s work on the neural circuits involved in neurofibromatosis type 1 and developing gene therapy treatments for the condition, and how …

Evan Eichler and colleagues used targeted sequencing in large neurodevelopmental cohorts, including SPARK, to identify new risk genes and relate genotype to phenotypic presentation.

Since launching in 2016, SPARK has driven scientific discovery in autism, building a cohort of over 280,000 individuals, including more than 100,000 children and adults with …

Vanessa Troiani and colleagues demonstrated a linear relationship between pupil dilation, reward/punishment sensitivity and individual ASD diagnostic status.

Robi Mitra and colleagues have developed a scalable CRISPR/Cas9 RNA sequencing assay in a human neuronal differentiation cell model, enabling high-throughput assessments of how repression of …

Ten years after its launch, Simons Searchlight counts a community of 4,000 families, encompassing more than 150 genetic neurodevelopmental conditions. Thanks to the dedicated, highly motivated families …

SFARI Investigator Aakanksha Singhvi discusses her lab’s work and how the Bridge to Independence Award helped in her transition to working as an assistant professor.

SFARI Investigator Kevin Eggan discusses his research on induced pluripotent stem (iPS) cells and his collaboration with SFARI to provide a detailed characterization of iPS cell lines from …

Peter Kind and Loren Frank discuss their work using SFARI’s genetic rat models and their views on how these models will aid autism research.

SFARI Investigator David Ginty talks about the links between deficits in the sense of touch, tactile hypersensitivity, and alterations in social behaviors in autism.

Sharmila Banerjee-Basu, founder and chief scientific officer at MindSpec Inc., discusses SFARI Gene and how it is changing the face of autism genetics research.

SFARI Investigator Sung Han discusses his lab’s work and how the Bridge to Independence Award helped him launch his independent career in autism research.

SFARI Investigator Liqun Luo discusses the neurodevelopmental disorder Smith-Magenis syndrome and his lab’s efforts to understand its underlying biology.