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  • Bringing people and ideas together to fund, conduct, and share transformative science.

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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

  • All News
  • Research News
  • Funding Announcements
  • Newsletter Sign Up
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  • Media Relations

We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

  • Events Calendar
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  • Presidential Lectures
  • Presents
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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  • Simons Collaboration on Localization of Waves
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Science, Society & Culture
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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Cortical-subcortical interactions in goal-directed behavior.

    Publication
  2. Spatiotemporal dynamics of noradrenaline during learned behaviour.

    Publication
  3. Astrocyte glutamate transport is modulated by motor learning and regulates neuronal correlations and movement encoding by motor cortex neurons.

    Publication
  4. The role of GABAergic signalling in neurodevelopmental disorders.

    Publication
  5. Distinct prefrontal top-down circuits differentially modulate sensorimotor behavior.

    Publication
  6. Reflections on the past two decades of neuroscience.

    Publication
  7. Pharmacological enhancement of KCC2 gene expression exerts therapeutic effects on human Rett syndrome neurons and Mecp2 mutant mice

    Publication
  8. Neural mechanisms of sensorimotor transformation and action selection.

    Publication
  9. Rett syndrome: Insights into genetic, molecular and circuit mechanisms.

    Publication
  10. Major vault protein, a candidate gene in 16p11.2 microdeletion syndrome, is required for the homeostatic regulation of visual cortical plasticity.

    Publication
  11. MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling.

    Publication
  12. Two-photon imaging in mice shows striosomes and matrix have overlapping but differential reinforcement-related responses.

    Publication
  13. Jointly reduced inhibition and excitation underlies circuit-wide changes in cortical processing in Rett syndrome.

    Publication
  14. Developmental dynamics of Rett syndrome.

    Publication
  15. Genes, circuits, and precision therapies for autism and related neurodevelopmental disorders.

    Publication
  16. An acetylcholine-activated microcircuit drives temporal dynamics of cortical activity.

    Publication
  17. In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9.

    Publication
  18. Beta2-adrenergic receptor agonist ameliorates phenotypes and corrects microRNA-mediated IGF1 deficits in a mouse model of Rett syndrome.

    Publication
  19. Functional recovery with recombinant human IGF1 treatment in a mouse model of Rett Syndrome.

    Publication
  20. Safety, pharmacokinetics, and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome.

    Publication
  21. Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons.

    Publication
  22. Mechanisms and therapeutic challenges in autism spectrum disorders: Insights from Rett syndrome.

    Publication
  23. Rett syndrome: Genes, synapses, circuits, and therapeutics.

    Publication
  24. The emerging role of microRNAs in schizophrenia and autism spectrum disorders.

    Publication
  25. miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity.

    Publication
  26. Differential gene expression in the developing lateral geniculate nucleus and medial geniculate nucleus reveals novel roles for ZIC4 and FOXP2 in visual and auditory pathway development.

    Publication
  27. Reduced conditioned fear response in mice that lack DLX1 and show subtype-specific loss of interneurons.

    Publication
  28. Intrinsic patterning and experience-dependent mechanisms that generate eye-specific projections and binocular circuits in the visual pathway.

    Publication
  29. Partial reversal of Rett syndrome-like symptoms in MeCP2 mutant mice.

    Publication
  30. Haploinsufficiency for Pten and serotonin transporter cooperatively influences brain size and social behavior.

    Publication
  31. Gene expression patterns in visual cortex during the critical period: Synaptic stabilization and reversal by visual deprivation.

    Publication
  32. Tuned responses of astrocytes and their influence on hemodynamic signals in the visual cortex.

    Publication
  33. Ten_m3 regulates eye-specific patterning in the mammalian visual pathway and is required for binocular vision.

    Publication

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