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  • Bringing people and ideas together to fund, conduct, and share transformative science.

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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

  • All News
  • Research News
  • Funding Announcements
  • Newsletter Sign Up
  • Press Releases
  • Media Relations

We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

  • Events Calendar
  • Public Events
  • Presidential Lectures
  • Presents
  • Flatiron Events
  • Past Events

Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

  • All Open Positions
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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  • Simons Collaboration on Localization of Waves
  • Simons Collaboration on Plasticity and the Aging Brain
  • Simons Collaboration on Principles of Microbial Ecosystems
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Life Sciences
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Science, Society & Culture
  • Scientific Software Research Faculty Award
  • Simons Collaborations in MPS
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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Discovering the gene-brain-behavior link in autism via generative machine learning.

    Publication
  2. Abnormal auditory mismatch fields in children and adolescents with 16p11.2 deletion and 16p11.2 duplication.

    Publication
  3. Sensorimotor cortical oscillations during movement preparation in 16p11.2 deletion carriers.

    Publication
  4. Brain MR imaging findings and associated outcomes in carriers of the reciprocal copy number variation at 16p11.2.

    Publication
  5. Reciprocal white matter alterations due to 16p11.2 chromosomal deletions versus duplications.

    Publication
  6. Relationship between M100 auditory evoked response and auditory radiation microstructure in 16p11.2 deletion and duplication carriers.

    Publication
  7. Auditory evoked M100 response latency is delayed in children with 16p11.2 deletion but not 16p11.2 duplication.

    Publication
  8. Defining the effect of the 16p11.2 duplication on cognition, behavior, and medical comorbidities.

    Publication
  9. Abnormal auditory and language pathways in children with 16p11.2 deletion.

    Publication
  10. Opposing brain differences in 16p11.2 deletion and duplication carriers.

    Publication
  11. Aberrant white matter microstructure in children with 16p11.2 deletions.

    Publication
  12. A 600 kb deletion syndrome at 16p11.2 leads to energy imbalance and neuropsychiatric disorders.

    Publication

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