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  • Bringing people and ideas together to fund, conduct, and share transformative science.

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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

  • All News
  • Research News
  • Funding Announcements
  • Newsletter Sign Up
  • Press Releases
  • Media Relations

We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

  • Events Calendar
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  • Presidential Lectures
  • Presents
  • Flatiron Events
  • Past Events

Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

  • All Open Positions
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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  • Simons Collaboration on Localization of Waves
  • Simons Collaboration on Plasticity and the Aging Brain
  • Simons Collaboration on Principles of Microbial Ecosystems
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Autism & Neuroscience
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Life Sciences
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Science, Society & Culture
  • Scientific Software Research Faculty Award
  • Simons Collaborations in MPS
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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons.

    Publication
  2. The genetic control of stoichiometry underlying autism.

    Publication
  3. FMRP has a cell-type-specific role in CA1 pyramidal neurons to regulate autism-related transcripts and circadian memory.

    Publication
  4. FMRP binding to a ranked subset of long genes is revealed by coupled CLIP and TRAP in specific neuronal cell types.

    Publication
  5. AGO CLIP reveals an activated network for acute regulation of brain glutamate homeostasis in ischemic stroke.

    Publication
  6. Whole-genome deep-learning analysis identifies contribution of noncoding mutations to autism risk.

    Publication
  7. Differential NOVA2-mediated splicing in excitatory and inhibitory neurons regulates cortical development and cerebellar function.

    Publication
  8. Genomic patterns of de novo mutation in simplex autism.

    Publication
  9. De novo indels within introns contribute to ASD incidence.

    Publication
  10. Genome sequencing of autism-affected families reveals disruption of putative noncoding regulatory DNA.

    Publication
  11. miRNA-target chimeras reveal miRNA 3'-end pairing as a major determinant of Argonaute target specificity.

    Publication
  12. HITS-CLIP and integrative modeling define the RBFOX splicing-regulatory network linked to brain development and autism.

    Publication
  13. Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis.

    Publication
  14. De novo gene disruptions in children on the autistic spectrum.

    Publication

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