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  1. Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages

    Publication

  2. Astrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons

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  3. Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes

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  4. Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes

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  5. Ascertaining cells' synaptic connections and RNA expression simultaneously with barcoded rabies virus libraries

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  6. Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p.

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  7. Repeat polymorphisms in non-coding DNA underlie top genetic risk loci for glaucoma and colorectal cancer.

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  8. Comparative cellular analysis of motor cortex in human, marmoset and mouse

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    The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally conserved across mammals1. Here, using high-throughput transcriptomic and epigenomic profiling of more …

  9. Protein-coding repeat polymorphisms strongly shape diverse human phenotypes

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  10. Protein-coding repeat polymorphisms strongly shape diverse human phenotypes [Update]

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    [Figure: see text].

  11. Anterior thalamic dysfunction underlies cognitive deficits in a subset of neuropsychiatric disease models

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    Neuropsychiatric disorders are often accompanied by cognitive impairments/intellectual disability (ID). It is not clear whether there are converging mechanisms underlying these debilitating impairments. We found that many …

  12. Anterior thalamic dysfunction underlies cognitive deficits in a subset of neuropsychiatric disease models

    Publication
    Neuropsychiatric disorders are often accompanied by cognitive impairments/intellectual disability (ID). It is not clear whether there are converging mechanisms underlying these debilitating impairments. We found that many …

  13. Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder

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    Bipolar disorder (BD) is a serious mental illness with substantial common variant heritability. However, the role of rare coding variation in BD is not well established. We examined …

  14. Protein-coding repeat polymorphisms strongly shape diverse human phenotypes

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    Hundreds of the proteins encoded in human genomes contain domains that vary in size or copy number due to variable numbers of tandem repeats (VNTRs) in protein-coding …

  15. Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice

    Publication
    The complement component 4 (C4) gene is linked to schizophrenia and synaptic refinement. In humans, greater expression of C4A in the brain is associated with an increased risk …

  16. Insights into dispersed duplications and complex structural mutations from whole genome sequencing 706 families.

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  17. Single-cell RNA sequencing reveals compromised immune microenvironment in precursor stages of multiple myeloma

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    Precursor states of Multiple Myeloma (MM) and its native tumor microenvironment need in-depth molecular characterization to better stratify and treat patients at risk. Using single-cell RNA …

  18. Single-cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes.

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  19. Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

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    Microglia, the resident immune cells of the brain, rapidly change states in response to their environment, but we lack molecular and functional signatures of different microglial populations. Here …

  20. Insights into clonal haematopoiesis from 8,342 mosaic chromosomal alterations.

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  21. An analytical framework for whole-genome sequence association studies and its implications for autism spectrum disorder.

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  22. Whole genome sequencing in psychiatric disorders: the WGSPD consortium.

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  23. Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets.

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  24. Cryptic and complex chromosomal aberrations in early-onset neuropsychiatric disorders.

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