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  1. Mechanisms of Dominant Electrophysiological Features of Four Subtypes of Layer 1 Interneurons

    Publication

  2. Theory of the Multiregional Neocortex: Large-Scale Neural Dynamics and Distributed Cognition

    Publication
    The neocortex is a complex neurobiological system with many interacting regions. How these regions work together to subserve flexible behavior and cognition has become increasingly amenable to rigorous …

  3. Mechanisms of distributed working memory in a large-scale network of macaque neocortex

    Publication
    Neural activity underlying working memory is not a local phenomenon but distributed across multiple brain regions. To elucidate the circuit mechanism of such distributed activity, we developed an …

  4. Hierarchical timescales in the neocortex: Mathematical mechanism and biological insights

    Publication
    A cardinal feature of the neocortex is the progressive increase of the spatial receptive fields along the cortical hierarchy. Recently, theoretical and experimental findings have shown that the …

  5. 50 years of mnemonic persistent activity: quo vadis?

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    Half a century ago persistent spiking activity in the neocortex was discovered to be a neural substrate of working memory. Since then scientists have sought to understand this …

  6. A dopamine gradient controls access to distributed working memory in the large-scale monkey cortex

    Publication
    Dopamine is required for working memory, but how it modulates the large-scale cortex is unknown. Here, we report that dopamine receptor density per neuron, measured by autoradiography …

  7. Structural Attributes and Principles of the Neocortical Connectome in the Marmoset Monkey

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    The marmoset monkey has become an important primate model in Neuroscience. Here, we characterize salient statistical properties of interareal connections of the marmoset cerebral cortex, using data from …

  8. Brain connectomes come of age

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    Databases of consistent, directed- and weighted inter-areal connectivity for mouse, macaque and marmoset monkeys have recently become available and begun to be used to build structural and …

  9. Artificial Neural Networks for Neuroscientists: A Primer

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    Artificial neural networks (ANNs) are essential tools in machine learning that have drawn increasing attention in neuroscience. Besides offering powerful techniques for data analysis, ANNs provide a new …

  10. Computational neuroscience: a frontier of the 21st century

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    … inactivation of one area may have impacts on multiple brain regions that are hard to understand and insights can be gained by computational modeling as a complementary …

  11. Macroscopic gradients of synaptic excitation and inhibition in the neocortex.

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    With advances in connectomics, transcriptome and neurophysiological technologies, the neuroscience of brain-wide neural circuits is poised to take off. A major challenge is to understand how a …

  12. Circuit mechanisms for the maintenance and manipulation of information in working memory

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    Recently it has been proposed that information in working memory (WM) may not always be stored in persistent neuronal activity but can be maintained in ‘activity-silent’ hidden …

  13. Transforming the Choice Outcome to an Action Plan in Monkey Lateral Prefrontal Cortex: A Neural Circuit Model.

    Publication
    In economic decisions, we make a good-based choice first, then we transform the outcome into an action to obtain the good. To elucidate the network mechanisms for …

  14. Multimodal gradients across mouse cortex.

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    The primate cerebral cortex displays a hierarchy that extends from primary sensorimotor to association areas, supporting increasingly integrated function underpinned by a gradient of heterogeneity in the brain …

  15. Task representations in neural networks trained to perform many cognitive tasks

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    The brain has the ability to flexibly perform many tasks, but the underlying mechanism cannot be elucidated in traditional experimental and modeling studies designed for one task at …

  16. Engagement of Pulvino-cortical Feedforward and Feedback Pathways in Cognitive Computations.

    Publication
    Computational modeling of brain mechanisms of cognition has largely focused on the cortex, but recent experiments have shown that higher-order nuclei of the thalamus participate in major …

  17. Inter-areal Balanced Amplification Enhances Signal Propagation in a Large-Scale Circuit Model of the Primate Cortex

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    Understanding reliable signal transmission represents a notable challenge for cortical systems, which display a wide range of weights of feedforward and feedback connections among heterogeneous areas. We re …

  18. A disinhibitory circuit motif and flexible information routing in the brain.

    Publication
    In the mammalian neocortex, an area typically receives inputs from, and projects to, dozens of other areas. Mechanisms are needed to flexibly route information to the right place …

  19. Reward-based training of recurrent neural networks for cognitive and value-based tasks.

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    Trained neural network models, which exhibit features of neural activity recorded from behaving animals, may provide insights into the circuit mechanisms of cognitive functions through systematic analysis of …

  20. Working Memory and Decision-Making in a Frontoparietal Circuit Model.

    Publication
    … (PPC) at the core. It is not clear, however, what the contributions of PPC and PFC are in light of the computations that subserve working memory and …

  21. Computing by Robust Transience: How the Fronto-Parietal Network Performs Sequential, Category-Based Decisions

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    Decision making involves dynamic interplay between internal judgements and external perception, which has been investigated in delayed match-to-category (DMC) experiments. Our analysis of neural recordings shows …

  22. Stable population coding for working memory coexists with heterogeneous neural dynamics in prefrontal cortex

    Publication
    Working memory (WM) is a cognitive function for temporary maintenance and manipulation of information, which requires conversion of stimulus-driven signals into internal representations that are maintained across …

  23. Inhibitory Control in the Cortico-Basal Ganglia-Thalamocortical Loop: Complex Regulation and Interplay with Memory and Decision Processes

    Publication
    We developed a circuit model of spiking neurons that includes multiple pathways in the basal ganglia (BG) and is endowed with feedback mechanisms at three levels: cortical microcircuit …