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  1. BAcTrace, a tool for retrograde tracing of neuronal circuits in Drosophila

    Publication
    Animal behavior is encoded in neuronal circuits in the brain. To elucidate the function of these circuits, it is necessary to identify, record from and manipulate networks of …

  2. Coding of social novelty in the hippocampal CA2 region and its disruption and rescue in a 22q11.2 microdeletion mouse model

    Publication
    The hippocampal CA2 region is essential for social memory. To determine whether CA2 activity encodes social interactions, we recorded extracellularly from CA2 pyramidal neurons (PNs) in male mice …

  3. Circadian control of brain glymphatic and lymphatic fluid flow

    Publication
    The glymphatic system is a network of perivascular spaces that promotes movement of cerebrospinal fluid (CSF) into the brain and clearance of metabolic waste. This fluid transport system …

  4. Engineering quantum materials with chiral optical cavities

    Publication

  5. Ultrafast Real-Time Dynamics of CO Oxidation over an Oxide Photocatalyst

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  6. Polariton panorama

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  7. Dynamical amplification of electric polarization through nonlinear phononics in 2D SnTe

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  8. Quantitative sampling of atomic-scale electromagnetic waveforms

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  9. Cas9 gene therapy for Angelman syndrome traps Ube3a-ATS long non-coding RNA.

    Publication

  10. Atypical development of attentional control associates with later adaptive functioning, autism and ADHD traits.

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  11. Revealing the structure of pharmacobehavioral space through motion sequencing.

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  12. Cleaning our own dust: simulating and separating galactic dust foregrounds with neural networks

    Publication
    Separating galactic foreground emission from maps of the cosmic microwave background (CMB), and quantifying the uncertainty in the CMB maps due to errors in foreground separation are important …

  13. The Effects of Depth Cues and Vestibular Translation Signals on the Rotation Tolerance of Heading Tuning in Macaque Area MSTd

    Publication
    When the eyes rotate during translational self-motion, the focus of expansion (FOE) in optic flow no longer indicates heading, yet heading judgements are largely unbiased. Much emphasis …

  14. Targeted Activation of Hippocampal Place Cells Drives Memory-Guided Spatial Behavior

    Publication
    The hippocampus is crucial for spatial navigation and episodic memory formation. Hippocampal place cells exhibit spatially selective activity within an environment and have been proposed to form the …

  15. A configurable model of the synaptic proteome reveals the molecular mechanisms of disease co-morbidity.

    Publication

  16. Brunner syndrome associated MAOA dysfunction in human dopaminergic neurons results in NMDAR hyperfunction and increased network activity.

    Publication

  17. Kernel Aggregated Fast Multipole Method: Efficient summation of Laplace and Stokes kernel functions

    Publication
    Many different simulation methods for Stokes flow problems involve a common computationally intense task—the summation of a kernel function over O(N2) pairs of points. One popular …

  18. Modeling flexible behavior in childhood to adulthood shows age-dependent learning mechanisms and less optimal learning in autism in each age group.

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  19. The Anterior Cingulate Cortex Predicts Future States to Mediate Model-Based Action Selection

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    Behavioral control is not unitary. It comprises parallel systems, model based and model free, that respectively generate flexible and habitual behaviors. Model-based decisions use predictions of the …

  20. Gamete simulation improves polygenic transmission disequilibrium analysis.

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  21. How many neurons are sufficient for perception of cortical activity?

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    Many theories of brain function propose that activity in sparse subsets of neurons underlies perception and action. To place a lower bound on the amount of neural activity …

  22. Biologically plausible single-layer networks for nonnegative independent component analysis

    Publication
    Blind source separation, the problem of separating mixtures of unknown signals into their distinct sources, is an important problem for both biological and engineered signal processing systems. Nonnegative …

  23. A biologically plausible neural network for Slow Feature Analysis

    Publication
    Learning latent features from time series data is an important problem in both machine learning and brain function. One approach, called Slow Feature Analysis (SFA), leverages the slowness …

  24. A simple normative network approximates local non-Hebbian learning in the cortex

    Publication
    To guide behavior, the brain extracts relevant features from high-dimensional data streamed by sensory organs. Neuroscience experiments demonstrate that the processing of sensory inputs by cortical neurons …

  25. Specificities of modeling membrane proteins using multi-template homology modeling

    Publication
    Structures of membrane proteins are challenging to determine experimentally and currently represent only about 2% of the structures in the ProteinDataBank. Because of this disparity, methods for modeling …

  26. An approach for long-term, multi-probe Neuropixels recordings in unrestrained rats

    Publication
    The use of Neuropixels probes for chronic neural recordings is in its infancy and initial studies leave questions about long-term stability and probe reusability unaddressed. Here we …

  27. Anomaly Detection for Multivariate Time Series of Exotic Supernovae

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    Supernovae mark the explosive deaths of stars and enrich the cosmos with heavy elements. Future telescopes will discover thousands of new supernovae nightly, creating a need to flag …

  28. Regulation of neural gene expression by estrogen receptor alpha.

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  29. Metformin rescues Parkinson's disease phenotypes caused by hyperactive mitochondria

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    Metabolic dysfunction occurs in many age-related neurodegenerative diseases, yet its role in disease etiology remains poorly understood. We recently discovered a potential causal link between the branched …

  30. Brain-wide, scale-wide physiology underlying behavioral flexibility in zebrafish

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    The brain is tasked with choosing actions that maximize an animal's chances of survival and reproduction. These choices must be flexible and informed by the current state …

  31. Distributional Reinforcement Learning in the Brain

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    Learning about rewards and punishments is critical for survival. Classical studies have demonstrated an impressive correspondence between the firing of dopamine neurons in the mammalian midbrain and the …

  32. Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis

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    … identified. Gene expression data from brain tissue demonstrate association of ALCAM, ARAP1, GPC6, and RBFOX1 with brain β-amyloid load. Of 25 known loci associated with Alzheimer …

  33. Accurate brain age prediction with lightweight deep neural networks.

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  34. Mutations associated with neuropsychiatric conditions delineate functional brain connectivity dimensions contributing to autism and schizophrenia.

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  35. Computational design of mixed chirality peptide macrocycles with internal symmetry

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    Cyclic symmetry is frequent in protein and peptide homo‐oligomers, but extremely rare within a single chain, as it is not compatible with free N‐ and C‐termini …

  36. Heterozygous deletion of SYNGAP enzymatic domains in rats causes selective learning, social and seizure phenotypes.

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  37. Social interaction networks in the primate brain

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    Primate brains have evolved to understand and engage with their social world. Much about the structure of this world can be gleaned from social interactions. Circuits for the …

  38. Human cerebral organoids reveal early spatiotemporal dynamics and pharmacological responses of UBE3A.

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  39. Homotopic Action: A Pathway to Convergent Diagrammatic Theories

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  40. Fast Recurrent Processing via Ventrolateral Prefrontal Cortex Is Needed by the Primate Ventral Stream for Robust Core Visual Object Recognition

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    Distributed neural population spiking patterns in macaque inferior temporal (IT) cortex that support core object recognition require additional time to develop for specific, "late-solved" images. This suggests …

  41. Characterization of special interests in autism spectrum disorder: A brief review and pilot study using the special interests survey.

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  42. Developmental paths to anxiety in an autism-enriched infant cohort: The role of temperamental reactivity and regulation.

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  43. Data mining of human plasma proteins generates a multitude of highly predictive aging clocks that reflect different aspects of aging

    Publication
    We previously identified 529 proteins that had been reported by multiple different studies to change their expression level with age in human plasma. In the present study, we …

  44. SARS-CoV-2 receptor networks in diabetic and COVID-19 associated kidney disease

    Publication
    COVID-19 morbidity and mortality are increased via unknown mechanisms in patients with diabetes and kidney disease. SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) for entry …

  45. Alexithymia in autism: Cross-sectional and longitudinal associations with social-communication difficulties, anxiety and depression symptoms.

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  46. De novo missense variants disrupting protein-protein interactions affect risk for autism through gene co-expression and protein networks in neuronal cell types.

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  47. An avian cortical circuit for chunking tutor song syllables into simple vocal-motor units

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    How are brain circuits constructed to achieve complex goals? The brains of young songbirds develop motor circuits that achieve the goal of imitating a specific tutor song to …

  48. Prefrontal cortex exhibits multidimensional dynamic encoding during decision-making

    Publication
    Recent work has suggested that the prefrontal cortex (PFC) plays a key role in context-dependent perceptual decision-making. In this study, we addressed that role using a …