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Bringing people and ideas together to fund, conduct, and share transformative science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Letters to a Pre-Scientist

    Funded Work
    Pen-pal program that connects students in under-resourced schools with STEM professional mentors for a snail-mail letter exchange during science class.
  2. Science, Engineering and Mathematics Link Inc. — STEM Journal Club

    Funded Work
    National nonprofit organization established on the premise that exposure to the STEM community is critical to K-12 students pursuing STEM careers.
  3. Chickenshed NYC

    Funded Work
    Inclusive theater company whose community reflects the vast diversity of the broader population
  4. Seeing the Big Picture: Moving From One Molecule to Many

    December 15, 2021
    … large, fragile proteins to be analyzed in a mass spectrometer.  When combined with physical separation measures, these ionization approaches make it possible to analyze even extremely complex …
  5. A ‘Forest Fire’ Model of Cell Division Can Explain Clonal Dominance in Developing Tissue

    December 14, 2021
    A new study reveals that communication between cells encasing the developing fruit fly egg chamber induces unequal cell division, shedding light on a fundamental biological process.
  6. A Conversation With Steven Hyman About Animal Models for Autism Research

    December 13, 2021
    Steven Hyman discusses the use of disease model systems to study neuropsychiatric and neurodevelopmental conditions, highlighting their benefits and limitations, and stressing the importance of knowing what questions …
  7. New iPSC Lines From Simons Searchlight Participants Are Now Available

    December 13, 2021
    In conjunction with the Nancy Lurie Marks Family Foundation, SFARI is releasing 30 new induced pluripotent stem cell (iPSC) lines for use in autism research.
  8. SFARI Gene To Introduce EAGLE, a New ASD-Relevance Gene Scoring System

    December 10, 2021
    The ASD-relevance of genes in the SFARI Gene database will be assessed according to a new scoring system called EAGLE (Evaluation of Autism Gene Link Evidence). This …
  9. A Conversation With SFARI Scientists Alan Packer, Pamela Feliciano and Misia Kowanda About SFARI Gene Lists

    December 10, 2021
    SFARI senior scientist Alan Packer, SPARK director Pamela Feliciano, and former Simons Searchlight outreach manager Misia Kowanda discuss differences and similarities between the ASD gene lists maintained by …
  10. Boosting the Brain’s Brakes To Beat Memory Loss

    December 9, 2021
    Overactivity in the hippocampus, likely tied to lack of inhibition, underlies some age-related cognitive decline. Targeting those circuits shows early promise in slowing memory loss.
  11. Watch: Math and Physics Collide in the Collaboration of Mathematician Tai-Danae Bradley and Physicist Miles Stoudenmire

    December 8, 2021
    Tai-Danae Bradley of Alphabet Inc.’s Sandbox team and physicist Miles Stoudenmire of the Center for Computational Quantum Physics find their research paths intersect in the use …
  12. From the bioRxiv: A Selection of Recently Posted Papers From SCPAB Investigators and Others

    November 30, 2021
    Each month, SCPAB scans the bioRxiv and arXiv for interesting papers from the SCPAB community and beyond.
  13. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    November 30, 2021
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  14. Hippocampal Replay: Reflection on the Past or Planning for the Future?

    November 30, 2021
    Weighing in on a long-standing debate, researchers show that these unique neural activity patterns relate more reliably to where you’ve been than to where you’re …
  15. New Simons Collaboration Aims To Provide a Mathematical Language for Fairness

    November 30, 2021
    A joint effort by a group of researchers finds a rigorous footing on which to evaluate social trade-offs.
  16. The Hidden Mathematical Patterns Behind Seemingly Random Events

    November 29, 2021
    Some aspects of everyday life follow predictable patterns, such the flow of traffic during a standard weekday. Such predictable patterns are easy to spot and chart, but even …
  17. Sabbatical Visiting Researcher Program 2022-2023 – Center for Computational Astrophysics

    November 29, 2021
    The Center for Computational Astrophysics (CCA) at the Simons Foundation’s Flatiron Institute is accepting requests from faculty members on sabbatical who are interested in visiting the CCA …
  18. Altered Hormone Signaling in the Brainstem Causes Motor Delays in 16p11.2 Mice

    November 22, 2021
    Simon Chen and colleagues found that a reduction in locus-coeruleus noradrenaline neuromodulatory signaling contributes to altered motor learning in 16p11.2 deletion mice.
  19. Autism BrainNet To Digitize the Autism Celloidin Library of Postmortem Brains

    November 22, 2021
    Autism BrainNet is working to digitize the Autism Celloidin Library, a unique collection of 28 celloidin-embedded, Nissl-stained brains from donors with and without autism spectrum disorder …
  20. How Speeding Up Science Aided the Fight Against COVID-19

    November 22, 2021
    … points. First, they needed to generate such data—and advances in automated systems, such as liquid handling and DNA sequencing, brought forth the desired deluge of information …
  21. Brain Aging Across Species

    November 19, 2021
    A new tool aligns research efforts in the aging brain in six different species.
  22. Moiré Materials Magic

    Funded Work
    Over the past couple of decades, researchers have learned how to prepare two-dimensional materials — crystals that are only one atom or one molecular layer thick — and measure …
  23. Astrophysical Investigations of Dynamical Chern–Simons Theory

    Funded Work
    This project will focus on dynamical Chern–Simons gravity.
  24. SFARI Investigators Awarded Nobel Prize, Lasker Award and MacArthur Fellowship

    November 18, 2021
    Three SFARI Investigators (current and past) have recently received prestigious prizes in the natural sciences.
  25. 2021 Genomics of ASD: Pathways to Genetic Therapies Awardees Announced

    November 17, 2021
    SFARI is pleased to announce that it intends to fund 17 grants in response to the 2021 Genomics of ASD: Pathways to Genetic Therapies request for applications.
  26. RhoA Overactivation May Underlie Smaller Brain Volumes in Cul3 Mutant Mice

    November 16, 2021
    Lilia Iakoucheva and colleagues found that mice lacking a copy of the high-confidence ASD risk gene Cul3 have reduced brain volumes, potentially due to defects in Rho …
  27. Tandem Repeat Mutations in Autism

    November 16, 2021
    Melissa Gymrek and colleagues developed a framework for the identification and prioritization of de novo mutations at tandem repeats on a genome-wide scale and assessed their contribution …
  28. A Bus Ride to Microscopic Worlds

    November 16, 2021
    How a retrofitted old transit bus turned into a fleet of science vehicles engaging students
  29. Paradoxical Material a Mashup of Three Different Phases at Once, Quantum Physicists Find

    November 10, 2021
    ‘Geometric frustration’ can cause the electrons in materials with atoms arranged in a triangular pattern to organize in three competing ways simultaneously, reveals a new computational study …
  30. SCGB Presentations at the 2021 Society for Neuroscience Conference

    November 4, 2021
    Check out these presentations from SCGB PIs and trainees at the virtual SFN conference November 8-11.
  31. Neuro-oscillatory function and network communication in autism

    Funded Work
    Brain imaging research strongly suggests that autism spectrum disorder (ASD) involves altered function in multiple neural networks.
  32. ‘Spergelfest’ Symposium Celebrates Astrophysicist David Spergel’s Career, Fifth Anniversary of the Center for Computational Astrophysics

    November 1, 2021
    … best wishes via prerecorded video message, lauding Spergel’s work in encouraging — and guiding — government funding of science. The celebrations focused not only on Spergel but also …
  33. Neuroscience 2021: Presentations by SFARI Investigators

    October 28, 2021
    A number of presentations will be given by SFARI Investigators at Neuroscience 2021 (November 8–11).
  34. Watch: David Spergel Inaugurated as President of the Simons Foundation

    October 28, 2021
    … celebrate his inauguration. Simons Foundation president David Spergel and guests celebrate his inauguration. Simons Foundation president David Spergel and guests celebrate his inauguration. Simons Foundation president David …
  35. The Fascinating Symphony at Play Between the Gut’s Neurons, Immune Cells and Microbes

    October 28, 2021
    Our gut is tasked with a unique challenge: to maintain tolerance of food and healthy microbes, while protecting the body from invading pathogens. A delicate balance between neurons …
  36. SFARI Investigators Elected to the National Academy of Medicine in 2021

    October 27, 2021
    Three SFARI Investigators (current and past) are among this year’s 100 newly elected members of the National Academy of Medicine.
  37. From the bioRxiv: A Selection of Recently Posted Papers From SCPAB Investigators and Others

    October 27, 2021
    Each month, SCPAB scans the bioRxiv and arXiv for interesting papers from the SCPAB community and beyond.
  38. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    October 27, 2021
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  39. Astrophysicists Reveal Largest-Ever Suite of Universe Simulations

    October 24, 2021
    The AbacusSummit simulations will help scientists extract information about the universe from upcoming cosmological surveys.
  40. Astrophysicist Blakesley Burkhart Receives American Physical Society’s Maria Goeppert Mayer Award

    October 15, 2021
    The American Physical Society has named Blakesley Burkhart the winner of the 2022 Maria Goeppert Mayer Award, which recognizes and enhances outstanding achievement by a woman physicist in …
  41. Regulation of cortical interneuron wiring in neurodevelopmental disorders

    Funded Work
    Tuberous sclerosis complex (TSC) is a genetic condition caused by inactivating mutations in TSC1 or TSC2 genes, with variable penetrance and severity.
  42. Simons-Supported Neuroscientists Win NIH Awards

    October 6, 2021
    The National Institutes of Health (NIH) has recognized four outstanding neuroscientists supported by the Simons Foundation. Coleen Murphy, director of the Simons Collaboration on Plasticity and the Aging …
  43. Simons Collaboration on the Global Brain Pledges New Funds To Explore How Brain Regions Interact

    October 6, 2021
    The grants bring to the collaboration new investigators studying how populations of neurons in different parts of the brain communicate.
  44. Single-neuron-resolution population dynamics in human Broca’s area and motor cortex when preparing and producing speech

    Funded Work
    Speech is a highly sophisticated, uniquely human behavior.
  45. How does the brain predict the future? Large-scale neural calcium imaging, two-photon optogenetic and deep neural network studies of future prediction across 11 neocortical areas in behaving mice

    Funded Work
    Prediction of the future and mental simulation of experiences are key to many forms of cognition and sensory processing.
  46. Computation timescales as an organizing principle of large-scale cortical dynamics during decision-making

    Funded Work
    The ability to make decisions lies at the core of cognition, but much remains unknown about its underlying neural mechanisms.
  47. Using brain-machine interfaces to identify and manipulate computational principles of learning

    Funded Work
    Learning a complex motor skill like playing tennis or a music instrument requires changes in connections between many neurons in the brain.
  48. Dissection of inter-area interactions of motor circuits

    Funded Work
    Behaviors are known to arise from numerous neurons communicating with each other within and across brain areas.
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