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Bringing people and ideas together to fund, conduct, and share transformative science.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    May 21, 2021
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  2. A Community (Sub)space for Science and Societal Engagement

    May 21, 2021
    The Boston Museum of Science puts diversity, inclusion and relationship building front and center in 2021 programming.
  3. Quanta Magazine Wins Webby People’s Voice Award for Best Science Website

    May 18, 2021
    … Webby winner, NASA’s Exoplanet Exploration website.
  4. CCM’s Alex H. Barnett, Joakim Andén Among Authors To Win Best Paper Award at the PDSEC-21 Conference

    May 18, 2021
    CCM’s Alex Barnett and Joakim Andén along with collaborators at NYU, Princeton University, and the Lawrence Berkeley National Laboratory (LBNL) have received the Best Paper Award at …
  5. Shrinking Planets Could Explain Mystery of Universe’s Missing Worlds

    May 14, 2021
    Studying data from the Kepler space telescope, Flatiron Institute researchers found that planetary shrinkage over billions of years likely explains a yearslong mystery: the scarcity of planets roughly …
  6. In Aging Worms, a Window Into Cognitive Decline

    May 13, 2021
    Worms have a rich repertoire of learning and memory behavior, which worsens with age. Scientists are unpacking the molecular mechanisms of that loss in hopes of finding ways …
  7. Cortical encoding of speech in autism

    Funded Work
    Among the most challenging aspects of autism is a variety of aural speech processing issues that deeply impact individuals’ language abilities.
  8. Neuron type-specific roles of Ube3a: Excitatory-inhibitory imbalance and seizures

    Funded Work
    Seizures are an extreme outcome of excitatory-inhibitory imbalance and are the most common neurological complication in autism spectrum disorder (ASD).
  9. New Application of Artificial Intelligence Just Removed One of the Biggest Roadblocks in Astrophysics

    May 4, 2021
    Using neural networks, Flatiron Institute research fellow Yin Li and his colleagues simulated vast, complex universes in a fraction of the time it takes with conventional methods.
  10. Seven Simons-Supported Researchers Elected to the National Academy of Sciences

    May 4, 2021
    Seven researchers affiliated with the Simons Foundation have been elected as 2021 members of the National Academy of Sciences. The researchers are among 120 new members and 30 …
  11. American Academy of Arts and Sciences Elects Six Simons Research Grantees 

    May 4, 2021
    Six researchers who have received support from the Simons Foundation are among the latest group of prominent artists, scholars, scientists and leaders elected as fellows of the American …
  12. Simons Searchlight: April 2021 Data Release

    April 29, 2021
    New Simons Searchlight data were recently added to SFARI Base. This data release included phenotypic data from individuals with 16p11.2 copy number variants (CNVs), 1q21.1 CNVs …
  13. SFARI Fall 2020 Science Meeting Highlights New Developments in Autism Research

    April 28, 2021
    Because of the coronavirus pandemic, SFARI ran the fall 2020 science meeting virtually in a series of six weekly webinars, beginning on October 2, 2020. SFARI investigators presented …
  14. Scabs and Failure: Springboards for a History-Making Vaccine

    April 27, 2021
    … to evoke immune responses to key parts of these relatively large organisms—bacteria and parasites being much bigger than viruses. Merging vaccinology and immunology With a better …
  15. Finding Beauty at the Piano and Elegance in Mathematics

    April 27, 2021
    Sylvain Carpentier, who is completing his tenure as a Simons Junior Fellow, has discovered new ways to promote the beauty of mathematics — both in its own right and …
  16. A Look Back: The Great Debate Over How the Motor Cortex Produces Movement

    April 23, 2021
    In an excerpt from her upcoming book, Grace Lindsay explores early theories for what motor cortex cells encode, where those theories went astray, and how today’s researchers …
  17. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    April 23, 2021
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  18. From the bioRxiv: A Selection of Recently Posted Papers From SCPAB Investigators and Others

    April 23, 2021
    Each month, SCPAB scans the bioRxiv and arXiv for interesting papers from the SCPAB community and beyond.
  19. Are Similar Processes at Work in Both Brain Development and Cognitive Decline?

    April 20, 2021
    Scientists are exploring how synaptic pruning, a process critical to brain function in childhood, may go awry as we age — and whether targeting the cells and immune molecules …
  20. Taking Care of Each Other, With Science and Solidarity

    April 19, 2021
    Aquí Nos Cuidamos puts science in service of marginalized communities in Puerto Rico and equips communities with the tools they need to combat COVID-19.
  21. Geometrical Thinking Offers a Window Into Computation

    April 7, 2021
    In a pair of studies, researchers use a novel way of examining data to explain how animals simultaneously encode tiny details and the big picture.
  22. A Conversation With SFARI Bridge to Independence Investigator Aakanksha Singhvi

    April 6, 2021
    SFARI Investigator Aakanksha Singhvi discusses her lab’s work and how the Bridge to Independence Award helped in her transition to working as an assistant professor.
  23. MPS Announces New Scientific Advisory Board Members

    April 1, 2021
    … of Computer Science. Tal has served as a member of the SIGACT Executive Board and a council member of the Computing Community Consortium. Tal is an ACM …
  24. Harnessing the Power of Evolution in the Battle Against COVID-19

    March 29, 2021
    … to measure how mutations in the coronavirus’s spike proteins, which adorn its surface like a crown, help SARS-CoV-2 evade the immune system. His team …
  25. The Vast Viral World: What We Know (and Don’t Know)

    March 29, 2021
    … Peru documented a 278-fold higher biting rate by mosquitos in deforested areas, compared with relatively pristine sites. Cases of malaria rose as mosquitos reproduced quickly in …
  26. How Mosquitoes Can Help Us Unpack the Mysteries of Memory and Behavior

    March 29, 2021
    We still have a lot to learn about how our cells retain memories and drive our behavior. Using an unlikely source of information, Simons Junior Fellow Leah Houri …
  27. A Conversation With Anthony Fauci About Funding Basic Research for Pandemic Preparedness

    March 29, 2021
    … research have to do with getting you, personally, to the position where you are now—where you’re widely admired and looked to for advice by a …
  28. Put a Mask On It: Understanding How COVID-19 Spreads

    March 29, 2021
    … think moving towards the future that we all like to live in, even aside from scarcity and shortages during pandemic times, we as a society should still …
  29. SFARI 2020 Director Awards Announced

    March 25, 2021
    SFARI is pleased to announce that eight Director Awards were awarded in 2020. These projects include, but are not limited to, studies that aim to enhance existing SFARI …
  30. Sex Differential Effects of Excitation-Inhibition Imbalance in Autism

    March 24, 2021
    Stefano Panzeri and colleagues used neuroimaging-derived measures to assess the sex differential impact of excitation/inhibition imbalance in idiopathic ASD.
  31. ASD Risk Genes and Homeostatic Plasticity

    March 24, 2021
    Graeme Davis and colleagues showed that ASD risk genes genetically interact with a class of common modifiers of presynaptic homeostatic plasticity at the Drosophila neuromuscular junction.
  32. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    March 24, 2021
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  33. Quantum Showdown: Competing Methods of Solving Quantum Systems Put to the Test

    March 23, 2021
    A many-method study of the Hubbard model demonstrates how the field of computational quantum physics is evolving to be more collaborative.
  34. Fruit Fly Egg Takes an Active Hand in Its Own Growth, Highlighting Parallels to Mammals

    March 22, 2021
    … the sheet of follicle cells that surrounds it. “These two tissue types need to grow together, and later, the follicle cells that stay over the nurse cells …
  35. From the bioRxiv: A Selection of Recently Posted Papers From SCPAB Investigators and Others

    March 22, 2021
    Each month, SCPAB scans the bioRxiv and arXiv for interesting papers from the SCPAB community and beyond.
  36. The Connected Connectome Part 2: Beyond the Fly

    March 22, 2021
    Success in flies and worms has inspired several efforts to reconstruct more complex mammalian brain circuits. Reconstructing a whole mouse brain using electron microscopy is the next logical …
  37. Simons Collaboration on Cracking the Glass Problem Holds 2021 Annual Meeting Online

    March 19, 2021
    The Simons Collaboration on Cracking the Glass Problem met remotely to provide research highlights from the past year. Collaboration director Sidney Nagel provided a collaboration overview, followed by …
  38. How Clumps of Misshapen Proteins Gum Up Aging Brains

    March 18, 2021
    Mounting evidence points to a central culprit behind the normal cognitive decline we see during aging: the formation of protein aggregates in the brain
  39. Assessing how the autism risk gene ASXL3 regulates cortical neuronal fate

    Funded Work
    Autism spectrum disorder (ASD) is a complex brain condition with a developmental etiology rooted in corticogenesis.
  40. New Class of Junior Fellows Joins the Simons Society of Fellows

    March 8, 2021
    The Simons Foundation is pleased to announce that 12 outstanding early-career scientists have joined the Simons Society of Fellows as the program’s latest class of Junior …
  41. Pandemic-Friendly Speed Dating for Neuroscientists

    March 4, 2021
    BRAIN Initiative researchers developed a virtual format to foster data-sharing among experimental and computational projects.
  42. Computation Opens New Doors for Science

    March 4, 2021
    At the Flatiron Institute, researchers across domains have access to powerful processors and a team of computing specialists.
  43. Investigating BKCa channel agonists as a potential treatment of atypical sensory information processing in autism

    Funded Work
    Atypical sensory experience is a core feature of autism spectrum disorder (ASD) and is strongly determinant of other ASD traits.
  44. Understanding and reversing large protein underproduction in fragile X–associated conditions

    Funded Work
    In order for the brain to carry out its complex functions, gene expression must be precisely controlled at the levels of transcription and translation.
  45. Investigating social communication and attachment deficits in prairie vole models of autism

    Funded Work
    Social attachments form the basis of human relationships at every level of social organization, from relationships between parents and children, romantic partners, to peers and group affiliation.
  46. Updates to SFARI’s 2021 Requests for Grant Applications

    March 1, 2021
    SFARI’s requests for grant applications (RFAs) will be undergoing a number of changes in 2021. These changes include the introduction of the new Human Cognitive and Behavioral …
  47. Identification and validation of expression quantitative trait loci (eQTLs) in discrete cell types across human brain development

    Funded Work
    Functional genomic analyses of the developing human brain have revealed highly dynamic spatiotemporal patterns of gene expression and epigenetic changes during prenatal and early postnatal development and across …
  48. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    March 1, 2021
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
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