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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Achieving More With Less: Optimizing Efficiency in Supercomputing

    February 22, 2023
    Flatiron Institute software engineer Géraud Krawezik works to minimize supercomputer energy use — with a focus on improving software performance for scientists.
  2. Simons Foundation Scientists Named as Sloan Research Fellows

    February 16, 2023
    The Alfred P. Sloan Foundation has awarded its prestigious research fellowship to four past and present Simons Foundation researchers. This year’s 125 fellowship recipients “represent the most …
  3. Computational Biology Goes Under the Microscope

    February 14, 2023
    A new facility at the Flatiron Institute’s Center for Computational Biology (CCB) bridges the gap between experimental and theoretical biology, allowing researchers to take big steps toward …
  4. Interview: Suzanne Pierre From Critical Ecology Lab

    February 14, 2023
    The second edition of our Science Sandbox Spotlight series features Dr. Suzanne Pierre, founder and principal investigator of Critical Ecology Lab.
  5. A New Era of Perception Research

    February 10, 2023
    How we perceive the world is an age-old question. Flatiron Institute researcher Jingyang Zhou is part of a new generation of scientists tackling it from a different …
  6. CCM Director Leslie Greengard Awarded ICIAM Pioneer Prize

    January 31, 2023
    … applications, from chip simulation to molecular modeling. In 2000, the Institute of Electrical and Electronics Engineers recognized the FMM as one of the top ten algorithms of …
  7. Neuroscientists Grapple With New Data Management Rules

    January 30, 2023
    New grant applications to the National Institutes of Health must include a plan for data-sharing and management. Researchers hope the broad requirement will boost development and adoption …
  8. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    January 30, 2023
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  9. Quarks, Wormholes and a New Understanding of the Physical World

    January 30, 2023
    By building models of the subatomic world, theoretical physicist Fedor Popov is working to strengthen our knowledge of the universe’s underlying principles.
  10. Small Cell, Big Picture: Fundamental Biology Through the Lens of Simplified Models

    January 26, 2023
    The nucleus of a cell may only be one-thousandth of a centimeter in diameter, but that doesn’t stop biophysicist Alex Rautu from seeing the big picture.
  11. January 2023 Update: New Simons Searchlight Data Added to SFARI Base

    January 25, 2023
    New Simons Searchlight data were recently added to SFARI Base. The data released included phenotypic data from individuals with 16p11.2 copy number variant (CNVs), 1q21.1 CNVs …
  12. Simons Foundation Providing Support to Researchers in Ukraine

    January 25, 2023
    … other members of the Simons Foundation staff. Ultimately, the Simons Foundation accepted every application it received and extended the application period as many scientists lost power and …
  13. Colin Hill and Oliver Philcox Among Winners of Buchalter Cosmology Prize

    January 24, 2023
    First place for this year’s Buchalter Cosmology Prize went to a paper co-authored by Colin Hill, until recently a Flatiron Institute associate research scientist and currently …
  14. ‘Fire of Love’ Nominated for the Academy Award for Best Documentary

    January 24, 2023
    … nominations. “Fire of Love” was produced by Sandbox Films, Intuitive Pictures and Cottage M and distributed by National Geographic Documentary Films and Neon. “Fire of Love” is …
  15. Big Data and Powerful Computing Join Forces To Link DNA Sequence and Function

    January 24, 2023
    Built from one of the world’s largest collections of epigenetic data, the newly developed model Sei predicts how DNA sequence variation alters gene expression, advancing our understanding …
  16. Astrophysicist Chiara Mingarelli Awarded the 2023 HEAD Early Career Prize

    January 19, 2023
    … International Outgoing Fellow at the California Institute of Technology and the Max Planck Institute for Radio Astronomy. She completed her Ph.D. at the University of Birmingham …
  17. Announcing the 2023 Simons Foundation Presidential Lectures

    January 18, 2023
    … hydrodynamics, optics, quantum mechanics and electrodynamics. Biology: Microbiomes The theme of the 2023 lecture series in biology is “Microbiomes.” Microscopic lifeforms live just about everywhere on Earth …
  18. Simons Society of Fellows Welcomes Senior Fellow E. Jane Hubbard

    January 15, 2023
    … the Genetics Society of America (GSA), having served as GSA president in 2022. Today, she continues to serve on several GSA committees, including the public communication and …
  19. Jumpy Genes in the Aging Brain

    January 11, 2023
    Scientists are exploring whether aging brain cells lose the ability to control mobile sequences of DNA, known as transposable elements, triggering inflammation and other issues.
  20. Doomed Pair of Supermassive Black Holes the Closest to Collision Ever Seen

    January 9, 2023
    New observations and analysis by Flatiron Institute researchers and their colleagues reveal two Goliath black holes just 750 light-years apart and closing, as they circle each other …
  21. One Scientist. One Filmmaker. One Week To Make a Film

    January 9, 2023
    Six pairs of scientists and filmmakers come together to co-create a short film over the course of one week.
  22. From the bioRxiv: A Selection of Recently Posted Papers From SCPAB Investigators and Others

    January 4, 2023
    Each month, SCPAB scans the bioRxiv and arXiv for interesting papers from the SCPAB community and beyond.
  23. SPARK December 2022 update: New Phenotypic Data Available

    January 4, 2023
    Phenotypic data from 310,649 participants enrolled in SPARK, including 123,444 individuals with ASD, are now available to approved researchers. Genomic data (whole-exome sequencing and genome …
  24. Cori Bargmann Joins Simons Foundation Board of Directors

    January 3, 2023
    The Simons Foundation is pleased to announce that neurobiologist and geneticist Cori Bargmann has joined its board of directors. Bargmann is the Torsten N. Wiesel Professor and head …
  25. Mapping the Neural Circuits That Guide Worms To Reproduce

    December 20, 2022
    Neuroscientist Robert W. Fernandez works to resolve many open questions about how roundworms function. He simultaneously strives to make scientific fields more diverse.
  26. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    December 19, 2022
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  27. A New Era for the Neuroscience of Social Behavior

    December 15, 2022
    Machine learning and neural theory pave new avenues in historically challenging terrain.
  28. The Radiant Research of a Black Hole and Massive-Star Modeler

    December 14, 2022
    From black holes to massive stars, Flatiron theoretical astrophysicist Yan-Fei Jiang is working to tackle some of the hardest problems in modeling extreme cosmic environments.
  29. How the ‘Hell Planet’ Got So Hot

    December 8, 2022
    New ultra-precise measurements reveal the orbital path of planet 55 Cnc e (nicknamed “Janssen”), a scorchingly hot super-Earth closely circling a distant star. The findings, made …
  30. Watch: Xie Chen on the Challenge and Promise of Quantum Information Systems

    December 7, 2022
    A CalTech professor of theoretical physics and a 2021 Simons Investigator, Xie Chen uses ideas and tools in quantum information to explore topological states of matter and study …
  31. Building Bridges Through Neuroscience

    December 7, 2022
    At a summer school designed to bring together students from across the Middle East and elsewhere, participants find common ground in science and beyond.
  32. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    November 29, 2022
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  33. Simons Foundation Opens Applications for Independence Awards

    November 29, 2022
    … from candidates with backgrounds in neuroscience, molecular biology, genetics, immunology, cell biology and the physical and information sciences. Applications are open to individuals from racial, ethnic and …
  34. How Our Genes Reassemble Themselves To Get Work Done

    November 29, 2022
    By analyzing cells under the microscope, Simons Junior Fellow Joan Pulupa is working to understand the interaction between the ways genes configure themselves and how different cell types …
  35. Simons Searchlight Gathers Families and Researchers for Conference on CSNK2A1 and SETBP1–Related Conditions

    November 28, 2022
    On August 4, 2022, SFARI and Simons Searchlight helped to host two scientific workshops focused on neurodevelopmental disorders (NDDs) that are linked to mutations in the CSNK2A1 and …
  36. Crossing the Divide: Defining Neurons by Both Genes and Function

    November 22, 2022
    With better tools for exploring the many facets of neurons, neuroscientists are building a more detailed glossary of cell types in the mammalian brain.
  37. Controlling the Complexity: Tuning Quantum Materials for Science and Technology

    November 22, 2022
    In quantum materials, electrons interact in complicated ways. At the Flatiron Institute, Sophie Beck is modeling how these electron dynamics shape materials properties to help lay the groundwork …
  38. From the bioRxiv: A Selection of Recently Posted Papers From SCPAB Investigators and Others

    November 15, 2022
    Each month, SCPAB scans the bioRxiv and arXiv for interesting papers from the SCPAB community and beyond.
  39. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    November 15, 2022
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  40. New Flatiron Institute Supercomputer the Most Power-Efficient Ever Built

    November 14, 2022
    Leveraging the new machine’s speed and parallel processing, researchers will apply machine-learning techniques to open questions in science.
  41. Simons Foundation Seeks Proposals for New Neuroscience Collaborations

    November 14, 2022
    … share data, code, analysis pipelines, protocols and reagents with the broader community. The foundation expects proposals to include junior investigators and investigators from a diversity of academic …
  42. Simons Foundation Dedicates the Marion T. Greenup Conference Center

    November 10, 2022
    The new meeting space is named for Marion Greenup, the foundation’s vice president of administration.
  43. Watch: Jané Kondev and the Mathematics of Biology

    November 8, 2022
    Jané Kondev, a physicist at Brandeis University, discusses his work using the tools of mathematics and theoretical physics to uncover laws that govern the inner workings of cells.
  44. Putting the Code in Scientific Computation

    November 7, 2022
    Combining a biophysics background with extensive computer experience, the Flatiron Institute’s Robert Blackwell works to improve computational programming for his own projects and for the broader scientific …
  45. SCGB Presentations at the 2022 Society for Neuroscience Conference

    November 4, 2022
    Check out these presentations from SCGB PIs and trainees at the SFN conference November 12-16.
  46. David Byrne’s Theater of the Mind

    October 31, 2022
    You never know what you’ll find in the Theater of the Mind.
  47. Mighty Mouse Models of Memory

    October 27, 2022
    Genetically diverse mice offer insight into why some animals age better than others — and may highlight routes to cognitive resilience.
  48. Making Electrons Behave In New and Unexpected Ways

    October 25, 2022
    Simons Junior Fellow Aravind Devarakonda began studying electronics in high school. Today, he uses both physics and chemistry to discover new insights about how electrons behave.
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