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  • Bringing people and ideas together to fund, conduct, and share transformative science.

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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. CCB Seminar: A Bayesian Framework for Cryo-EM Heterogeneity Analysis using Regularized Covariance Estimation (Marc Gilles, Ph.D., Princeton University)

    Seminar
    Speaker: Marc A. Gilles (Princeton University) Title: A Bayesian Framework for Cryo-EM Heterogeneity Analysis using Regularized Covariance Estimation Abstract: Proteins and the complexes they form are central …
  2. CCB Colloquium: Finding all our switches: biophysics at scale to globally map and understand allosteric communication in proteins (Ben Lehner, Ph.D., Wellcome Sanger Institute)

    Colloquium
    … therapeutic target. Allosteric propagation is particularly effective across the central beta sheet of KRAS and multiple surface pockets are genetically-validated as allosterically active, including a distal …
  3. Structural and Molecular Biophysics Group Meeting

    Meeting
  4. Genomics Group Meeting

    Meeting
  5. Biophysical Modeling Group Meeting

    Meeting
  6. Developmental Dynamics Group Meeting

    Meeting
  7. Genomics Group Meeting

    Meeting
  8. Structural and Molecular Biophysics Group Meeting

    Meeting
  9. Biophysical Modeling Group Meeting

    Meeting
  10. Developmental Dynamics Group Meeting

    Meeting
  11. Genomics Group Meeting

    Meeting
  12. Biophysical Modeling Group Meeting

    Meeting
  13. Developmental Dynamics Group Meeting

    Meeting
  14. CCB Brown Bag Seminar

    Seminar
  15. Genomics Group Meeting

    Meeting
  16. Structural and Molecular Biophysics Group Meeting

    Meeting
  17. Biophysical Modeling Group Meeting

    Meeting
  18. Developmental Dynamics Group Meeting

    Meeting
  19. CCB Colloquium: Signal Propagation in Recurrent Networks

    Colloquium
    Speaker: Marcelo Magnasco Professor and Head of Lab of Integrative Neuroscience, Rockefeller University Title: Signal propagation in recurrent networks When the linear component of the dynamics of a …
  20. Structural and Molecular Biophysics Group Meeting

    Meeting
  21. Genomics Group Meeting

    Meeting
  22. Biophysical Modeling Group Meeting

    Meeting
  23. Developmental Dynamics Group Meeting

    Meeting
  24. CCB Brown Bag Seminar

    Seminar
  25. EMIG Seminar: Imaging and Segmenting Vitrified Neurons (Matt Swulius, Ph.D., Penn State University)

    Seminar
    Matt Swulius is an Assistant Professor in the Biochemistry and Molecular Biology department at the Penn State college of medicine. He is also a Scientific Director of the …
  26. Genomics Group Meeting

    Meeting
  27. Structural and Molecular Biophysics Group Meeting

    Meeting
  28. Biophysical Modeling Group Meeting

    Meeting
  29. Developmental Dynamics Group Meeting

    Meeting
  30. DICE (Dynamics in Cells and Embryos) Conference

    Conference
    Although some biological processes are highly stereotyped, others exhibit large degrees of variability. In many cases, this variability is core to the biological function of that process. DICE …
  31. Structural and Molecular Biophysics Group Meeting

    Meeting
  32. Genomics Group Meeting

    Meeting
  33. Biophysical Modeling Group Meeting

    Meeting
  34. Developmental Dynamics Group Meeting

    Meeting
  35. Structural and Molecular Biophysics Group Meeting

    Meeting
  36. Genomics Group Meeting

    Meeting
  37. Developmental Dynamics Group Meeting

    Meeting
  38. CCB Colloquium: Many-to-many protein networks: Modules of multicellularity (Michael Elowitz, Ph.D., California Institute of Technology)

    Colloquium
    Speaker: Michael Elowitz, Ph.D. Professor of Biology and Bioengineering, California Institute of Technology Investigator, Howard Hughes Medical Institute Title: Many-to-many protein networks: modules of multicellularity …
  39. EMIG Seminar: Enhancing the Image: Developing Computational Tools for Cryo-EM (Timothy Grant, Ph.D., University of Wisconsin-Madison)

    Seminar
    Speaker:  Timothy Grant, Ph.D.,  Assistant Professor University of Wisconsin – Madison Title: Enhancing the Image: Developing Computational Tools for Cryo-EM Cryo-EM has recently undergone rapid progress …
  40. Genomics Group Meeting

    Meeting
  41. Developmental Dynamics Group Meeting

    Meeting
  42. CCB Seminar: Nonequilibrium Physics for Living Systems (Yuhai Tu, Ph.D., IBM TJ Watson Research Center)

    Seminar
    Speaker: Yuhai Tu, Ph.D., IBM T. J. Watson Research Center Topic: Nonequilibrium Physics for Living Systems Complex systems with many degrees of freedom and/or many interacting …
  43. IDEAS Scholar Lecture/CCB Colloquium: Computational Microbiology of Bacterial Cell Envelopes: Successes, Limitations and Scope for Collaborations (Dr. Syma Khalid, University of Oxford)

    Colloquium
    Speaker: Dr. Syma Khalid, University of Oxford Title: Computational Microbiology of Bacterial Cell Envelopes: Successes, Limitations and Scope for Collaborations Bacterial cell envelopes are compositionally complex, crowded and …
  44. CCB Seminar: Symmetry breaking and collective effects in biological physics (Daniel Riveline, Ph.D., University of Strasbourg)

    Meeting
    Speaker: Daniel Riveline, Ph.D. (University of Strasbourg, France) Topic: Symmetry breaking and collective effects in biological physics Biological cells move, divide, change their shapes, adhere to their …
  45. CCB Seminar:Algal Phototaxis and the Evolution of Multicellularity (Ray Goldstein, Ph.D., University of Cambridge))

    Meeting
    Speaker: Ray Goldstein, Ph.DSchlumberger Professor of Complex Physical Systems in the Department of Applied Mathematics and Theoretical Physics (DAMTP) at the University of Cambridge Title: Algal Phototaxis …
  46. CryoEM Summer Workshop

    Workshop
    CryoEM Summer Workshop from summer 2023 For more detailed information, go here. 
  47. CCB Seminar: Exploring the wave nature of life across scales - from active matter to ecology (Tom Shimizu, Ph.D., AMOLF)

    Meeting
    Speaker: Tom Shimizu, Ph.D., AMOLF Topic: Exploring the wave nature of life across scales – from active matter to ecology Viewed at sufficiently large scales, the dynamics of …
  48. CCB Colloquium: Locomotion of Flagellated Bacteria: The Influence of Complex Fluids and the Role of Multiflagellarity (Xiang Chen, Ph.D., University of Minnesota)

    Colloquium
    … drag on their larger bodies. Without such a collective balancing mechanism, the swimming speed of uniflagellar bacteria generically decreases with increasing body size. As such, our study …
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