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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Multiscale Mechanobiology Journal Club

    Meeting
  2. EMIG Seminar: Three CryoEM stories: discovery of a new pathogen, escaping pseudosymmetry traps, and limitations to resolution (Jason Kaelber, Ph.D., Rutgers University)

    Meeting
    Speaker: Jason Kaelber, Rutgers University Title: Three CryoEM stories: discovery of a new pathogen, escaping pseudosymmetry traps, and limitations to resolution. To crack a nationwide pandemic in farmed …
  3. CCB Brown Bag Seminar

    Meeting
    Speaker: Gilles Francfort, Ph.D., Research Scientist Topic: The role of stability in macroscopic solids with defects This is meant to be a short narration of the efforts …
  4. Systems Biology Group Meeting

    Meeting
  5. CCB Brown Bag Seminar

    Meeting
    … is critical to many biological processes such as the sensation of temperature. Here we will demonstrate the use of machine learning based techniques to study heterogeneity in …
  6. Systems Biology Group Meeting

    Meeting
  7. Multiscale Mechanobiology Journal Club

    Meeting
  8. CCB Colloquium: Sequence-based deep learning models of immune cell differentiation (Sara Mostafavi, Ph.D., University of Washington)

    Colloquium
    Speaker: Sara Mostafavi, Ph.D., Paul Allen School of Computer Science and Engineering at University of Washington (UW). Topic: Sequence-based deep learning models of immune cell differentiation …
  9. CCB Seminar: Making microvascular networks work: angiogenesis, remodeling and pruning (Timothy W. Secomb, Ph.D., University of Arizona)

    Meeting
    Speaker: Timothy W. Secomb, Ph.D., University of Arizona, Title: Making microvascular networks work: angiogenesis, remodeling and pruning Physiological transport of materials is accomplished mainly by convective transport …
  10. CCB Brown Bag Seminar

    Meeting
    Speaker: Stas Shvartsman, Ph.D.
  11. Systems Biology Group Meeting

    Meeting
  12. Multiscale Mechanobiology Journal Club

    Meeting
  13. Multiscale Mechanobiology Journal Club

    Meeting
  14. Systems Biology Group Meeting

    Meeting
  15. CCB Colloquium: The molecular basis of cellular electricity (Roderick MacKinnon, Ph.D., Laboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, The Rockefeller University)

    Colloquium
    Speaker: Roderick MacKinnon, Ph.D. Laboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, The Rockefeller University Title: The molecular basis of cellular electricity Life has exploited …
  16. Systems Biology Group Meeting

    Meeting
  17. CCB Short Course: Intro to Information Theory in Biology

    Meeting
    Lecturer: Henry Mattingly, Associate Research Scientist, Biophysical Modeling In the 1940s, Claude Shannon invented information theory, afundamental tool for quantifying statistical uncertainty andinference. The fact that it deals …
  18. CCB Seminar: Wet active matter: Controlling the dynamics of microswimmers (Holger Stark, Ph.D., Technical University of Berlin)

    Meeting
    Speaker: Holger Stark, Ph.D. Institute for Theoretical Physics Technical University of Berlin Title: Wet active matter: Controlling the dynamics of microswimmers Wet active matter refers to microswimmers …
  19. EMIG Seminar: Machine learning for determining protein structure and dynamics from cryo-EM images (Ellen Zhong, Ph.D., Princeton University)

    Meeting
    Speaker: Ellen Zhong, Ph.D. Assistant Professor, Department of Computer Science Princeton University Title: Machine learning for determining protein structure and dynamics from cryo-EM images Major technological …
  20. Systems Biology Group Meeting

    Meeting
  21. CCB Short Course: Intro to Information Theory in Biology

    Meeting
    Lecturer: Henry Mattingly, Associate Research Scientist, Biophysical Modeling In the 1940s, Claude Shannon invented information theory, afundamental tool for quantifying statistical uncertainty andinference. The fact that it deals …
  22. Systems Biology Group Meeting

    Meeting
  23. CCB Short Course: Intro to Information Theory in Biology

    Meeting
    Lecturer: Henry Mattingly, Associate Research Scientist, Biophysical Modeling In the 1940s, Claude Shannon invented information theory, afundamental tool for quantifying statistical uncertainty andinference. The fact that it deals …
  24. Systems Biology Group Meeting

    Meeting
  25. CCB Short Course: Intro to Information Theory in Biology

    Meeting
    Lecturer: Henry Mattingly, Associate Research Scientist, Biophysical Modeling In the 1940s, Claude Shannon invented information theory, afundamental tool for quantifying statistical uncertainty andinference. The fact that it deals …
  26. CCB Seminar: Natalie Sauerwald, Ph.D, Flatiron Research Fellow (Genomics)

    Meeting
    Speaker: Natalie Sauerwald, Ph.D. Flatiron Research Fellow (Genomics) Title: Analysis frameworks for sequencing data Next generation sequencing (NGS), the revolutionary technology that allows for the rapid and …
  27. CCB Seminar: Wilson Bennett Lough (UW-Madison)

    Meeting
    Speaker: Wilson Bennett Lough, UW–Madison Research, teaching and outreach in Physics Title: Self-buckling and self-writhing of semi-flexible microorganisms Multi-flagellated microorganisms can buckle and …
  28. Systems Biology Group Meeting

    Meeting
  29. CCB Short Course: Intro to Information Theory in Biology

    Meeting
    Lecturer: Henry Mattingly, Associate Research Scientist, Biophysical Modeling In the 1940s, Claude Shannon invented information theory, afundamental tool for quantifying statistical uncertainty andinference. The fact that it deals …
  30. CCB Brown Bag Seminar

    Meeting
    Speaker: Vikram Mulligan, Ph.D., Research Scientist, Systems Biology Topic: Next-generation software for heteropolymer design and structure prediction For decades, the Rosetta software suite has been one …
  31. Systems Biology Group Meeting

    Meeting
  32. CCB Colloquium: Pratyush Tiwary, Ph.D. (University of Maryland)

    Colloquium
    Speaker: Pratyush Tiwary, Ph.D., Associate Professor, University of Maryland-College Park
  33. Systems Biology Group Meeting

    Meeting
  34. CCB Seminar: Lisa Fauci, Ph.D. (Tulane University)

    Meeting
    Speaker: Lisa Fauci, Ph. D Pendergraft Nola Lee Haynes Professor, Tulane UniversitySchool of Science & Engineering Title: Insights from biofluidmechanics: A tale of two tails I will present recent …
  35. CCB Brown Bag Seminar

    Meeting
    1st speaker: Adam Lamson, Ph.D. , Flatiron Research Fellow, BpM & Genomics Topic: Characterizing a new polymer model for condensed flexible biofilament Cells form DNA-protein condensates inside the …
  36. Systems Biology Group Meeting

    Meeting
  37. CCB Short Course: An Introduction to Information Theory in Biology

    Meeting
  38. CCB Colloquium: Liat Shenhav, Ph.D. (Rockefeller University)

    Colloquium
    Speaker: Liat Shenhav, Ph.D., Fellow, Center for Studies in Physics and Biology, Rockefeller University
  39. CCB Short Course: An Introduction to Information Theory in Biology

    Meeting
  40. CCB Colloquium: Julien Tailleur, Ph.D. (MIT)

    Colloquium
    Speaker: Julien Tailleur, Associate Professor of Physics, Massachusetts Institute of Technology
  41. CCB Colloquium: Julien Tailleur, Ph.D. (Massachusetts Institute of Technology)

    Colloquium
    Speaker: Julien Tailleur, Ph.D., Associate Professor of Physics, Massachusetts Institute of Technology Title: The many surprises of active matter Active matter describes systems in which individual units …
  42. CCB Short Course: An Introduction to Information Theory in Biology

    Meeting
  43. CCB Seminar: RNA guided DNA rearrangements and RNA-DNA hybrids (Nataša Jonoska, Ph.D., University of South Florida)

    Meeting
    Speaker: Nataša Jonoska, Ph.D. Professor of Mathematics, University of South Florida Title: RNA guided DNA rearrangements and RNA-DNA hybrids We concentrate on two non-standard roles …
  44. CCB Seminar: RNA guided DNA rearrangements and RNA-DNA hybrids (Nataša Jonoska, Ph.D., University of South Florida)

    Meeting
    Speaker: Nataša Jonoska, Ph.D. Professor of Mathematics, University of South Florida Title: RNA guided DNA rearrangements and RNA-DNA hybrids We concentrate on two non-standard roles …
  45. CCB Colloquium: Hana El-Samad, Ph.D. (UC San Francisco)

    Colloquium
    Speaker: Hana El-Samad, Ph.D., Professor, Biochemistry and Biophysics, University of California, San Francisco
  46. Systems Biology Group Meeting

    Meeting
  47. CCB Short Course: An Introduction to Information Theory in Biology

    Meeting
  48. CCB Seminar: Ivo Sbalzarini, Ph.D. (Max Planck Institute of Molecular Cell Biology and Genetics)

    Colloquium
    Speaker: Ivo Sbalzarini, Ph.D., Group Leader, Max Planck Institute of Molecular Cell Biology and Genetics)
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