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Genetic and phenotypic heterogeneity occurs in many diseases, including autism.

In this project, Jeffrey Macklis will directly investigate interhemispheric callosal projection neuron (CPN) axonal growth cone (GC) molecular machinery, abnormalities of CPN connectivity and dose-dependent direct effects …

High confidence ASD (hcASD) genes encode proteins that regulate synapse formation, neuronal activity and transcription regulation, including chromatin regulation.

Multiple behaviors disrupted in autism spectrum disorders (ASDs), including the integration of sensory stimuli and social interaction, are associated with the dysfunction of striatal synapses.

A number of genetic mutations have been linked to an increased risk for autism spectrum disorder (ASD).

Our group is helping Rafael Yuste’s lab to pioneer the use of Hydra vulgaris, a small, freshwater polyp that attaches itself to underwater surfaces in lakes, rivers …

Working memory, the ability to temporarily hold and manipulate pieces of information in our minds, is crucial for thinking and flexible behavior.

We take it for granted that we can distinguish similar events yet still group them together as being similar.

Imagine you are rowing a boat in a river.

A massive cultural center dedicated to experimentation, education and production across disciplines, housed in a converted warehouse in the Red Hook neighborhood of Brooklyn.

The human brain is composed of billions of neurons.

Our interaction with the world is influenced by our internal state.

The cellular and developmental basis of autism spectrum disorder (ASD) still represents a significant gap in our knowledge of this developmental disorder.

Finding treatments for autism spectrum disorder (ASD) has been challenging because its etiology is so poorly understood.

Imbalances in excitatory versus inhibitory postsynaptic signaling in the central nervous system (CNS) have been associated with autism spectrum disorders (ASD).

Autism spectrum disorder (ASD) is a major neurodevelopmental disorder, yet despite its prevalence and severity, the substantial genetic heterogeneity of ASD (>700 associated genes) has been a major …

Approximately 30 percent of autism spectrum disorder (ASD) cases can be explained by rare de novo variants disrupting gene function.

Math organization creating pathways for students from low-income and historically marginalized communities to become scientists, mathematicians, engineers and computer scientists.

Autism spectrum disorder (ASD) is seen as a collection of disorders that is predominantly developmental in nature and largely genetic in origin.

The Simons Initiative for the Developing Brain (SIDB) was established in 2017.

Most individuals with autism experience at least one form of hypersensitivity from the five senses.

It has been established that children and adolescents with autism spectrum disorder (ASD) show a wide range of abilities to use spoken words and establish interactive conversations.

Autism spectrum disorder (ASD) afflicts 1 in 68 individuals in the United States and represents a substantial emotional and financial burden on our society.

Autism spectrum disorders (ASDs) are characterized by a variety of behavioral deficits including perseverative behavior.

Very little is known about the potential neural abnormalities that exist in the initial stages of autism development.

A number of studies have lead to the suggestion that disruptions to chloride homeostasis play a role in a variety of neurological and neurodevelopmental disorders.

Little is known or understood about the molecular mechanisms responsible for social cognitive development and the diseases associated with its aberrations, such as autism spectrum disorder (ASD).

Whole-exome sequencing studies utilizing samples from the Simons Simplex Collection and other autism cohorts have identified multiple variants in SCN2A, a gene encoding a neuronal voltage-gated …

Several key barriers exist to unraveling the mechanistic etiologies of autism spectrum disorder (ASD).

Autism spectrum disorders (ASDs) encompass a number of disorders that are typified by communication deficits, reduced behavioral flexibility, poor socialization, learning disabilities and a tendency toward repetitive behaviors.

Autism is a neurodevelopmental disorder, and sensorimotor disturbances are among the earliest signs of atypical development in autism, revealing themselves in early infancy.

Genetic risks for autism are diverse and encompass mutations and copy number variations in hundreds of genes.

Genetic analyses of copy-number variants, single-nucleotide variants and chromosomal translocations, as well as co-expression network analysis of postmortem brain tissue, have implicated the human RBFOX1 …

“What is life?” is a question that has occupied mankind for thousands of years.

Autism is a neurodevelopmental disorder in which individuals display a range of challenges in social cognition, language and sensory perception.

Neuroimaging studies have described altered structural and functional connectivity across brain regions of individuals with autism spectrum disorder (ASD).

Hundreds of susceptibility genes have been identified for autism spectrum disorder (ASD), and many are related to synaptic function.

Anthony Wynshaw-Boris and his colleagues are investigating the hypothesis that a subset of individuals with autism spectrum disorders (ASD) (approximately 25-30 percent) display early brain overgrowth.

The gene encoding the transcription factor FOXP1 is strongly implicated in the etiology of individuals with autism spectrum disorder (ASD) and of those with intellectual disability.

Autism spectrum disorders (ASDs) represent a group of neurodevelopmental disorders for which the underlying etiologies are heterogeneous.

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that is the result of interplay amongst hundreds of genes.

Motor dysfunction is common in autism.

The diagnostic dyad defining autism spectrum disorder (ASD) belies a tremendous phenotypic heterogeneity that remains a key challenge to diagnosis and treatment.

Somatic mosaicism, or the emergence of variations in the sequence or structure of the genome of somatic cells, has been detected in both healthy individuals and individuals with …

Components of the mammalian target of rapamycin (mTOR) signaling pathway are key players in the pathogenesis of autism spectrum disorder (ASD).