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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. CCB Brown Bag Seminar

    Meeting
  2. Systems Biology Group Meeting

    Meeting
  3. CCB Short Course: An Introduction to Information Theory in Biology

    Meeting
  4. Systems Biology Group Meeting

    Meeting
  5. Systems Biology Group Meeting

    Meeting
  6. CCB Seminar: Programmable Folding of Droplet Colloidomers (Jasna Brujic, Ph.D., New York University):

    Meeting
    … These supracolloids can in turn interact to make more complex architectures, such as dimers, tubules and mosaics, seeding a new generation of life-like materials. Our results …
  7. Electron Microscopy Interest Group Seminar: Bridget Carragher, Ph.D. (New York Structural Biology Center)

    Meeting
  8. CCB Seminar: Bandit Problems, Clinical Trials, and Computational Ethics (William H. Press, UT-Austin)

    Meeting
    Speaker: William H. Press, Ph.D.Leslie Surginer Professor of Computer Sciences and Integrative Biology, University of Texas at AustinScientific Advisory Board, Flatiron Institute Title: Bandit Problems, Clinical …
  9. Systems Biology Group Meeting

    Meeting
  10. CCB Seminar: Differential nuclear import sets the timing of protein access to the embryonic genome (Martin Wühr, Ph.D., Princeton University)

    Meeting
    Speaker: Martin H. Wühr, Lewis-Sigler Institute for Integrative Genomics, Princeton University Topic: Differential nuclear import sets the timing of protein access to the embryonic genome The development …
  11. CCB Seminar: Viscoelastic instabilities in microfluidic flows (Amy Shen, Ph.D., Okinawa Institute of Science and Technology Graduate University))

    Meeting
    Speaker: Amy Q. Shen, Ph.D., Micro/Bio/Nanofluidics Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa, Japan Topic: Viscoelastic instabilities in microfluidic flows Microfluidics has …
  12. CCB Brown Bag Seminar

    Meeting
    Presenter: Lisa Brown, Ph.D., Senior Data Scientist, Developmental Dynamics Topic: Lineage Reconstruction for Preimplantation Mouse Embryogenesis I will present our work in reconstructing cell lineages from time …
  13. Systems Biology Group Meeting

    Meeting
  14. Systems Biology Group Meeting

    Meeting
  15. CCB Seminar: A computational perspective on cytoskeletal self-assembly processes across scales: from the mitotic spindle to protein-membrane interactions (Chris Edelmaier, Ph.D., University of North Carolina)

    Meeting
    Speaker: Chris Edelmaier, Ph.D. (University of North Carolina) Topic: A computational perspective on cytoskeletal self-assembly processes across scales: from the mitotic spindle to protein-membrane interactions …
  16. CCB Brown Bag Seminar

    Meeting
    Presenter: Julia Koehler Leman (Research Scientist, Systems Biology) Presenter: Tatyana Gavrilchenko (Flatiron Research Fellow, Developmental Dynamics)
  17. Systems Biology Group Meeting

    Meeting
  18. IDEAS Scholar Lecture/CCB Colloquium: "Computational challenges in a densely sequenced tree of life"

    Colloquium
    Speaker: Dr. Katherine S. Pollard (University of California, San Francisco) Title: Computational Challenges in a densely sequenced tree of life Genome sequencing and assembly have exploded since 2015 …
  19. Systems Biology Group Meeting

    Meeting
  20. Electron Microscopy Interest Group Meeting

    Meeting
    Speakers: Joshua Carmichael, Garrett Wright, Christopher Langfield, Princeton University Topic: ASPIRE – A Python Package for Single Particle Reconstruction We demonstrate ASPIRE’s functionality by running through a typical …
  21. Systems Biology Group Meeting

    Meeting
  22. CCB Brown Bag Seminar

    Meeting
    Presenter: Justin Lindsay, (Flatiron Research Fellow, Structural and Molecular Biophysics) Presenter: David Stein, (Research Scientist, Biophysical Modeling)
  23. CCB Brown Bag Seminar

    Meeting
    Presenter: Reza Farhadifar (Research Scientist, Biophysical Modeling Group) Presenter: Chen Lin (Flatiron Research Fellow, Structural and Molecular Biophysics)
  24. CCB Summer Interns Poster Session

    Meeting
  25. CCB Seminar: Fragment-Based Ligand Generation Guided By Geometric Deep Learning On Protein-Ligand Structure (Helen Yu, Ph.D., Stanford University)

    Meeting
    Speaker: Helen Yu, Ph.D., Stanford University Topic: Fragment-Based Ligand Generation Guided By Geometric Deep Learning On Protein-Ligand Structure Computationally-aided design of novel molecules has …
  26. CCB Seminar: Sensing transcription factors in the fly embryo (Marianne Bauer, Ph.D., Delft University of Technology)

    Meeting
    Speaker: Marianne Bauer, Ph.D., Delft University of Technology Topic: Sensing transcription factors in the fly embryo Transcription factor concentrations can be seen as signals that need to …
  27. CCB Seminar: Altered protein dynamics and transition kinetics delineate oncogenic potential in mutated kinases (Ravi Radhakrishnan, Ph.D, University of Pennsylvania)

    Meeting
    … protein dynamics to validate our model. Our enhanced atomistic simulations are a significant improvement over unbiased molecular dynamics techniques to study protein dynamics and transition kinetics and …
  28. Electron Microscopy Interest Group Meeting

    Meeting
    Speakers: Jake D. Johnston, New York Structural Biology Center Reza Paraan, New York Structural Biology Center
  29. CCB Seminar: Hydronamics of slender swimmers near deformable interfaces (Sankalp Nambiar, Nordic Institute for Theoretical Physics)

    Meeting
    Speaker: Sankalp Nambiar, Nordic Institute for Theoretical Physics Title: Hydrodynamics of slender swimmers near deformable interfaces We study the coupled hydrodynamics between a motile slender microswimmer and a …
  30. CCB Seminar: Weight loss dependent and independent effects of bariatric surgery (Danny Beh-Ziv, Hebrew University of Jersualem)

    Meeting
    Speaker: Danny Beh-Zvi, The Hebrew University of Jerusalem Topic: Weight loss dependent and independent effects of bariatric (weight loss) surgery Bariatric, AKA weight-loss surgery, is an …
  31. CCB Seminar: Ciliary control of chromosomal pairing mechanics in meiosis, and cellular control of phase-separation in oocyte polarity – two tales, common cellular machinery (Yaniv Elkouby, Hebrew University of Jersualem)

    Meeting
    … microscopy, molecular, and biochemical evidence to show that Bb granules initially undergo liquid-liquid phase separation, and then gradually lipid-solid phase- separation in forming the mature …
  32. Electron Microscopy Interest Group Meeting

    Meeting
    Are you interested in electron microscopy? Do you use or analyze cryo-electron- tomography data? Are you developing methods for single particle analysis? Have you just started studying …
  33. CCB Seminar: "Massive Linear Swimmers at Low Reynolds Number"" (Oleg Trosman, Friedrich-Alexander University Erlangen-Nuremberg)

    Seminar
    Massive Linear Swimmers at Low Reynolds Number Two possibilities of description of swimmers’ motion, the stroke-based as well as the force-based one, are showcased, both of …
  34. CCB Seminar: "Machine Learning Strategies for Alternate Splicing" (Zhicheng Pan, UCLA)

    Seminar
    … of 8,304 samples across 53 tissues from the GTEx project. We demonstrate that iDARTS can help to identify the causal effects of common and rare genomic …
  35. Computer Vision Interest Group Seminar: "Scalable and Flexible Connectomics Segmentation with PyTorch Connectomics" (Zudi Linn, Harvard University)

    Meeting
    Presenter: Zudi Linn, Harvard University Title: Scalable and Flexible Connectomics Segmentation with PyTorch ConnectomicsWe present PyTorch Connectomics (PyTC), an open-source deep-learning framework for the semantic and …
  36. CCB Brown Bag Seminar

    Meeting
    Presenter: Lisa Brown, Ph.D., Senior Data Scientist, Developmental Dynamics Topic: Lineage Reconstruction for Preimplantation Mouse Embryogenesis I will present our work in reconstructing cell lineages from time …
  37. CCB Colloquium: "Visualization of correlated motions underlying enzyme function" (Doeke Hekstra, Harvard University)

    Colloquium
    Speaker: Doeke Hekstra, Assistant Professor of Moelcular and Cellular Biology, Harvard University Title: Visualization of correlated motions underlying enzyme function The conformational dynamics of proteins underlie key aspects …
  38. Mechanics of Life Workshop

    Workshop
    … (University of Pennsylvania) Nicolas Romeo (Massachusetts Institute of Technology) David Saintillan (University of California, San Diego) Joshua W. Shaevitz (Princeton University) Michael Shelley (Center for Computational Biology …
  39. Electron Microscopy Interest Group Meeting

    Meeting
    Are you interested in electron microscopy? Do you use or analyze cryo-electron- tomography data? Are you developing methods for single particle analysis? Have you just started studying …
  40. CCB Seminar: "Stability in the Face of Change: How Hormones Regulate and Coordinate Growth Across Environmental Conditions in Drosophila" (Alexander Shingleton, Ph.D., University of Illinois-Chicago)

    Seminar
    … different environmental conditions. Ultimately, our goal is to better understand how plasticity and robustness are achieved by the same developmental system, so that developing animals phenotypically match …
  41. CCB Seminar: "Inter-organ communication: A Drosophila perspective" (Norbert Perrimon, PhD, Harvard Medical School)

    Seminar
    Speaker: Norbert Perrimon, Ph.D., Professor of Genetics, Blavatnik Institute, Harvard Medical School Topic: Inter-organ communication: A Drosophila perspective Mathematical modelling has become increasingly integrated into biological …
  42. CCB Seminar: "Motility and morphodynamics of confined cells" (Ido Lavi, University of Barcelona)

    Seminar
    Speaker: Ido Lavi, University of Barcelona Title: Motility and morphodynamics of confined cells Under physiological conditions, immune cells and cancer cells typically move through highly restricted 3D environments …
  43. CCB Colloquium: "Life in a Tight Spot: How Bacteria Swim, Disperse, and Grow in Crowded Spaces" (Sujit Datta, Ph.D., Princeton University)

    Colloquium
    … Harvard, where he studied fluid dynamics and instabilities in porous media and colloidal microcapsules with David Weitz. His postdoctoral training was in Chemical Engineering at Caltech, where …
  44. CCB Seminar: "An overview of the dragonfly and damselfly tree of life" (Jessica Ware, Ph.D., American Museum of Natural History)

    Seminar
    Speaker: Jessica Ware, American Museum of Natural History, Curator of Odonata & non-Holometabolous Minor Orders Topic: An overview of the dragonfly and damselfly tree of life Dragonflies and …
  45. Systems Biology Group Meeting

    Meeting
  46. CCB Colloquium: "The mechanics of bio-inspired material intelligence" (Markus J. Buehler,Ph.D.)

    Colloquium
    Speaker: Markus J. Buehler McAfee Professor of Engineering, MIT Title: The mechanics of bio-inspired material intelligence Digital biomaterials are designed through an integrated approach of large-scale …
  47. Systems Biology Group Meeting

    Meeting
  48. Computer Vision Interest Group Seminar: "Neurotransmitter Classification from Electron Microscopy" (HHMI Janelia)

    Seminar
    Speaker: Jan Funke, Group Leader at HHMI Janelia Topic: Neurotransmitter Classification from Electron Microscopy In this talk, we will have a look at our ongoing work to discover …
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