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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Systems Biology Group Meeting

    Meeting
  2. CCB Colloquium: "Short Stories of Transport Processes and Molecular Biology" (Howard A. Stone, Ph.D.)

    Colloquium
    Speaker: Howard A. Stone Donald R. Dixon ’69 and Elizabeth W. Dixon Professor in Mechanical and Aerospace Engineering, Princeton University. Title: Short Stories of Transport Processes and Molecular …
  3. CCB Seminar: "Developmental Dynamics During Vertebrate Embryogenesis"

    Seminar
    Speaker: Alexander Schier, Ph.D., Director of the Biozentrum, University of Basel Title: Developmental dynamics during vertebrate embryogenesis Breakthroughs in single-cell genomics have begun to comprehensively identify …
  4. Systems Biology Group Meeting

    Meeting
    Speaker: Corey Taylor, Volkamer Lab Topic: QM/MM simulation – Introduction, practicalities and case studies Hybrid quantum mechanics/molecular mechanics (QM/MM) simulations are a popular tool for the …
  5. CCB Brown Bag Seminar

    Meeting
    1st speaker: Aidan Daly, Ph.D., Flatiron Research Fellow, Systems Biology Topic: Inferring cell type-specific gene expression signatures from multi-tissue spatial transcriptomics data 2nd speaker: Surya …
  6. Systems Biology Group Meeting

    Meeting
    Speaker: Corey Taylor, Volkamer Lab Topic: QM/MM simulation – Introduction, practicalities and case studies Hybrid quantum mechanics/molecular mechanics (QM/MM) simulations are a popular tool for the …
  7. CCB Seminar: "Coordinated motion of active filaments on spherical surfaces " (Eric Keaveny, Ph.D.)

    Seminar
    Speaker: Eric E. Keaveny Faculty of Natural Sciences, Department of Mathematics Imperial College London Title: Coordinated motion of active filaments on spherical surfaces Abstract: Filaments (slender, microscopic elastic …
  8. CCB Seminar: "Mechanochemical control of nuclear positioning in Drosophila embryos " (Stefano D'Italia, Ph.D)

    Seminar
    Speaker: Stefano Di Talia, Ph.D., Duke University School of Medicine Topic: Mechanochemical control of nuclear positioning in Drosophila embryos I will describe our attempts at understanding nuclear …
  9. CCB Colloquium: "Darwinian evolution as a principled physical process: What drives it? Where did it come from?" (Ken A. Dill, Ph.D.)

    Colloquium
    Speaker: Ken A. Dill, Distinguished Professor of Chemistry & Physics Stony Brook University Title: Darwinian evolution as a principled physical process. What drives it? Where did it come from …
  10. CCB Seminar: "Inferring entropy from structure" (Gil Ariel, Ph.D)

    Seminar
    Speaker: Gil Ariel, Associate Professor, Department of Mathematics, Bar Ilan Title: Inferring entropy from structure The thermodynamic definition of entropy can be extended to nonequilibrium systems based on …
  11. CCB Brown Bag Seminar

    Meeting
    1st speaker: Jasmin Alsous, Ph.D., Research Scientist, Developmental Dynamics Topic: Sperm Storage – an overlooked leg of the journey Before fertilizing the egg, sperm is typically stored in …
  12. CCB Seminar: "Molecular Mechanisms and Self Organization of Subcellular Structures for Cell Division, Polarization and Motion" (Dimitrios Vavylonis, Ph.D.)

    Seminar
    … the leading edge of polarized motile cells.
  13. Systems Biology Group Meeting

    Meeting
    Speaker: Corey Taylor, Volkamer Lab Topic: QM/MM simulation – Introduction, practicalities and case studies Hybrid quantum mechanics/molecular mechanics (QM/MM) simulations are a popular tool for the …
  14. CCB Seminar: "A systematic approach for predicting DNA recognition byCys2His2 zinc finger proteins" (Anton Persikov, Ph.D.)

    Seminar
    Speaker: Anton Persikov, Ph.D., Associate Research Scholar, Princeton University Topic: A systematic approach for predicting DNA recognition byCys2His2 zinc finger proteins Cys2His2 zinc finger (ZF) proteins represent …
  15. CCB Seminar: "A systematic approach for predicting DNA recognition byCys2His2 zinc finger proteins" (Anton Persikov, Ph.D.)

    Seminar
    Speaker: Anton Persikov, Ph.D., Associate Research Scholar, Princeton University Topic: A systematic approach for predicting DNA recognition byCys2His2 zinc finger proteins Cys2His2 zinc finger (ZF) proteins represent …
  16. CCB Colloquium: "Protein Structure Prediction in a Post-Alpha2 World" (Mohammed AlQuraishi, Ph.D.)

    Colloquium
    Speaker: Mohammed AlQuraishi Assistant Professor of Systems Biology (in Computer Science) Department Systems Biology Title: Protein structure prediction in a post-AlphaFold2 world AlphaFold2 burst on the life …
  17. Systems Biology Group Meeting

    Meeting
  18. CCB Seminar: Taeyoon Kim, Ph.D. (Purdue University): Reconstructing the Mechanical and Dynamic Behaviors of Cells in Silico

    Seminar
    Presenter: Taeyoon Kim, Associate Professor Purdue University, Weldon School of Biomedical Engineering Topic: Reconstructing the Mechanical and Dynamic Behaviors of Cells in Silico Actin cytoskeleton is a dynamic …
  19. CCB Seminar: "Reconstructing the Mechanical and Dynamic Behaviors of Cells in Silico" (Taeyoon Kim, Ph.D.)

    Seminar
    Speaker: Taeyoon Kim, Ph.D. Assistant Professor, Purdue University Title: Reconstructing the Mechanical and Dynamic Behaviors of Cells in Silico Actin cytoskeleton is a dynamic structural scaffold used …
  20. CCB Colloquium: "Multiscale Modeling of dementia: from proteins to cognitive functions" (Alain Goriely, Ph.D.)

    Colloquium
    Speaker: Alain Goriely, Ph.D. Title: Multiscale modeling of dementia: from proteins to cognitive functions Neurodegenerative diseases such as Alzheimer’s or Parkinson’s are devastating conditions with …
  21. IDEA Scholar Lecture: "Ageing men, their selfish testes, new mutations and human disease" (Anne Goriely, Ph.D.)

    Colloquium
    Speaker: Anne Goriely, Ph.D. Title: “Ageing men, their selfish testes, new mutations and human disease” Abstract: Because mutations are at the origin of all genetic variations, understanding …
  22. IDEA Scholar Lecture: "Ageing men, their selfish testes, new mutations and human disease" (Anne Goriely, Ph.D.)

    Colloquium
    Speaker: Anne Goriely, Ph.D. Title: “Ageing men, their selfish testes, new mutations and human disease” Abstract: Because mutations are at the origin of all genetic variations, understanding …
  23. Systems Biology Group Meeting

    Meeting
    Speaker: Corey Taylor, Volkamer Lab Topic: QM/MM simulation – Introduction, practicalities and case studies Hybrid quantum mechanics/molecular mechanics (QM/MM) simulations are a popular tool for the …
  24. CCB Seminar: Rogerio Feris, Ph.D. Rogerio Feris, Ph.D. (IBM T.J. Watson Research Center): Computational Visual Pathways for Multi-Task Learning and Simulation

    Seminar
    Presenter: Rogerio Feris, Research Manager (Computer Vision), Master Inventor (IBM T. J. Watson Research Center) Topic: Computational Visual Pathways for Multi-Task Learning and Simulation In this talk …
  25. CCB Seminar: Weiguang Mao, Ph.D. (University of Pittsburgh): Generative Models of Biological Variations in Bulk and Single-cell RNA-seq

    Seminar
    Presenter: Weiguang Mao, Ph.D. ( University of Pittsburgh) Topic: Generative Models of Biological Variations in Bulk and Single-cell RNA-seq The explosive growth of transcriptomic profiling has …
  26. Systems Biology Group Meeting

    Meeting
  27. CCB Seminar: Form and Function: Uterine 3D Structure-Function Relationships in Early Pregnancy

    Seminar
    Presenter: Ripla Arora, Ph.D. , Assistant Professor, Michigan State University Topic: Form and Function: Uterine 3D structure-function relationships in early pregnancy Although much is known about the …
  28. Systems Biology Group Meeting

    Meeting
  29. CCB Colloquium: All-Atom Molecular Simulations of Disordered and Flexible Proteins (Sarah Rauscher, Ph.D., University of Toronto)

    Colloquium
    Speaker: Sarah Rauscher, Ph.D., Assistant Professor, University of Toronto Topic: All-Atom Molecular Simulations of Disordered and Flexible Proteins Molecular dynamics (MD) simulations are a useful tool …
  30. CCB Seminar: Form and Function: Uterine 3D Structure-Function Relationships in Early Pregnancy

    Seminar
    Presenter: Ripla Arora, Ph.D. , Assistant Professor, Michigan State University Topic: Form and Function: Uterine 3D structure-function relationships in early pregnancy Although much is known about the …
  31. CCB Seminar: Designing a Customizable Platform for Small Molecule Drug Design Compatible with Protein Flexibility and Sequence Design

    Seminar
    Presenter: Benjamin P. Brown (Vanderbilt University School of Medicine) Topic: Designing a customizable platform for small molecule drug design compatible with protein flexibility and sequence design Computer-aided …
  32. CCB Seminar: Inference and modeling of biological networks, from active matter to the immune repertoire

    Seminar
    Presenter: Victor Chardès, Laboratoire de Physique de l’École Normale Supérieure Topic: Inference and modeling of biological networks, from active matter to the immune repertoire Active matter and …
  33. CCB Brown Bag Seminar

    Meeting
    1st Presenter: Wen Yan, Ph.D., Research Scientist, Biophysical Modeling Topic: Failures and lessons: the flip side of developing aLENS This short talk is a companion to my …
  34. CCB Seminar: How do inferences shape functions in biology?

    Seminar
    Presenter: Henry Mattingly, Ph.D., Yale University Topic: How do inferences shape functions in biology? Organisms’ survival depends on their abilities to sense the environment and act appropriately …
  35. Systems Biology Group Meeting

    Meeting
  36. CCB Seminar: Transcriptional coupling of neighboring genes in bacteria

    Seminar
    Presenter: Debora Tenenbaum, Ph.D. Student, Brandis University Topic: Transcriptional coupling of neighboring genes in bacteria Many cellular functions require the coordinated activity of multiple genes. In bacteria …
  37. CCB Seminar: Andrea Liu, Ph.D., Hepburn Professor of Physics, University of Pennsylvania: Learning about learning with physical networks

    Seminar
    Presenter: Andrea Liu, Ph.D., Hepburn Professor of Physics, University of Pennsylvania Title: Learning about learning with physical networks Physical networks such as mechanical spring networks or flow …
  38. CCB Seminar: Water-Explicit Polarizable Coarse-Grained Model For Simulations with Proteins

    Seminar
    … iterations to study neurodegenerative protein aggregation in presence of model membranes and other co-solutes.
  39. CCB Brown Bag Seminar

    Meeting
    … in gene expression space.
  40. CCB Seminar: Collective cell mechanics of organoids and epithelial sheets

    Seminar
    Presenter: Jan Rozman (Jožef Stefan Institute) Topic: Collective cell mechanics of organoids and epithelial sheets The study of organoids, artificially grown cell aggregates with the functionality and small …
  41. Systems Biology Group Meeting

    Meeting
    Presenter: Vikram Mulligan Topic: RosettaQM: Enabling quantum chemistry calculations in peptide and protein modelling Physics-based heteropolymer modelling methods remain an important complement to machine learning (ML) based …
  42. CCB Seminar: Topological Data Analytic Approach for Discovering Biophysical Signatures in Protein Dynamics

    Seminar
    Presenter: Wai Shing Tang (Brown University) Topic: Topological Data Analytic Approach for Discovering Biophysical Signatures in Protein Dynamics Identifying structural differences among proteins can be a non-trivial …
  43. CCB Seminar: From single cells to collective response in jammed model tissues

    Seminar
    Presenter: John Treado (Yale University) Topic: From single cells to collective response in jammed model tissues The mechanical, structural, and ultimately functional properties of tissues depend heavily on …
  44. CCB Colloquium: Eleni Katifori, Ph.D. (University of Pennsylvania)

    Colloquium
    … vascular topology.
  45. Systems Biology Group Meeting

    Meeting
    Presenter: Julia Koehler Leman Topic: How to write a scientific paper Scientific writing and scientific communication is the bread and butter of any scientist. Since I find myself …
  46. CCB Seminar: Water-Explicit Polarizable Coarse-Grained Model For Simulations with Proteins

    Seminar
    … iterations to study neurodegenerative protein aggregation in presence of model membranes and other co-solutes.
  47. CCB Seminar: An “individualist” model of an active genome in a developing embryo

    Seminar
    Presenter: Christine A. Rushlow, PhD (NYU) Topic: An “individualist” model of an active genome in a developing embryo The early Drosophila embryo provides unique experimental advantages for addressing …
  48. CCB Seminar: Probing the DNA binding specificity of transcription factor complexes with deep sequencing and biophysically interpretable machine learning

    Seminar
    Presenter: Harmen Bussemaker, Ph. D (Columbia University) Topic: Probing the DNA binding specificity of transcription factor complexes with deep sequencing and biophysically interpretable machine learning Quantifying sequence-specific …
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