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  • Bringing people and ideas together to fund, conduct, and share transformative science.

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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. CCB Seminar: Harmen Bussemaker

    Seminar
    Speaker: Harmen Bussemaker, PhD, Columbia University Topic: Probing the DNA binding specificity of transcription factor complexes with deep sequencing and biophysically interpretable machine learning Abstract: Quantifying sequence-specific …
  2. CCB Seminar: Collective motion of confined biased swimmers: magnetotactic bacteria in channels and spheres

    Seminar
    Presenter: Albane Thery (University of Cambridge) Topic: Collective motion of confined biased swimmers: magnetotactic bacteria in channels and spheres Magnetotactic bacteria (MTBs) synthesize magnets in their cytoplasm and …
  3. Systems Biology Group Meeting

    Meeting
    Presenter: Christopher Jackson Topic: Regulatory network inference using dynamic models Understanding how gene expression programs are controlled requires identifying regulatory relationships between transcription factors and target genes. These …
  4. CCB Seminar: Extreme Event Probability Estimation using PDE-Constrained Optimization and Large Deviation Theory, with Application to Tsunamis

    Seminar
    Presenter: Shanyin Tong (NYU/Courant Institute of Mathematical Sciences) Topic: Extreme Event Probability Estimation using PDE-Constrained Optimization and Large Deviation Theory, with Application to Tsunamis Extreme events …
  5. Computer Vision Interest Group Seminar

    Seminar
    Speaker: Carsen Stringer, Janelia Lab Topic: Cellpose and Suite2p: anatomical and functional algorithms for cellular segmentation Abstract: Many biological applications require the segmentation of cell bodies, membranes and …
  6. Brown Bag Seminar

    Seminar
    1st Speaker: Mike Shelley Topic: Welcome Back and Updates 2nd Speaker: Stas Shvartsman Topic: Maintaining symmetry in bilaterian morphogenesis
  7. Hormone Circuits Interest Group

    Meeting
    Speaker: Christopher Park, Ph.D., Research Scientist, Genomics Topic: We’ll talk a little more on the glucose-insulin circuits, then I’ll go over the paper I …
  8. CCB Brown Bag Seminar

    Seminar
    1st Presenter: Natalie Sauerwald, Ph.D., Flatiron Research Fellow, Genomics Topic: Differences in response to SARS-CoV-2 infection in male and female young adults Abstract: Male sex …
  9. CCB Seminar: Min Wu

    Seminar
    Speaker: Min Wu, Assistant Professor, Mathematical Sciences, Worcester Polytechnic Institute Title: Modes of size and shape regulation in cell wall and tumor spheroid growth
  10. 2021 Fall CCB Colloquia Schedule

    Colloquium
  11. CCB Colloquium: Stephan Grill

    Colloquium
    Topic: Cluster of Excellence Physics of Life Abstract: One of the most remarkable examples of self-organized structure formation is the development of a complex organism from a …
  12. Hormone Circuits Interest Group

    Meeting
    The group will focus on studying *hormone circuits*, which impact so much of human biology, disease (e.g. diabetes, depression) and behavior. No background is needed. The overall …
  13. CCB Colloquium: Richard Mann

    Colloquium
    Title: How flies make and use their appendages Abstract: My plan is to present an overview of the current efforts in my lab, providing necessary background when needed …
  14. CCB Colloquium: Elizabeth Gavin

    Colloquium
    Presenter: Dr. Elizabeth R. Gavin, Ph.D., DamonB. Pfeiffer Professor of MolecularBiology Associated Faculty of the Princeton Neuroscience Institute Princeton University Topic: Looking to the future: assembly and …
  15. Biophysics Development Seminar

    Seminar
    Presenter: M. Cristina Marchetti, Ph.D., Professor, Physics University of California, Santa Barbara Topic: Interfacial properties of active fluids Abstract: There are many situations where active fluids coexist …
  16. CCB Colloquium: Ray Goldstein

    Colloquium
    Presenter: Professor Raymond E. Goldstein FRS Schlumberger Professor of Complex Physical Systems Department of Applied Mathematics and Theoretical Physics Centre for Mathematical SciencesUniversity of Cambridge Topic: Cytoplasmic Streaming …
  17. 2021 Fall CCB Colloquia Schedule

    Colloquium
  18. CCB Brown Bag Seminar

    Seminar
    1st Speaker: Alex Rautu, Ph.D., Flatiron Research Fellow, Biophysical Modeling Topic: Composition, Shape and Drift Instabilities of Membrane-Bound Compartments under Active Vesicular Trafficking Abstract: We study …
  19. Hormone Circuits Interest Group Meeting

    Meeting
    How does the liver, pancreas, or any organ communicate with the brain or with each other? This is accomplished via hormones. Th Hormone Circuits Interest Groupw ill focus …
  20. Guest Seminar: Ellen V. Rothenberg

    Seminar
    Speaker: Ellen V. Rothenberg, Distinguished Professor of Biology, Division of Biology and Biological Engineering, California Institute of Technology Title: Gene network and epigenetic mechanisms controlling the dynamics and …
  21. CCB Colloquium: John Chodera

    Colloquium
  22. CCB Brown Bag Seminar

    Seminar
    1st.Presenter: Christopher Park, Ph.D., Research Scientist, Genomics Topic: The darker side of the genome – Long non-coding RNA Abstract: There are now more annotated long non …
  23. 2021 Fall CCB Colloquia Schedule

    Colloquium
  24. CCB Brown Bag Seminar

    Seminar
    1st presenter: Julia Koehler, Ph.D., Research Scientist & Project Leader, Systems Biology Topic: How to give engaging presentations Abstract: Communicating science is not easy but necessary to reach …
  25. CCB/CCM Colloquium: Mark E. Tuckerman

    Colloquium
    Presenter: Mark E. Tuckerman, Ph.D., Professor of Chemistry and Mathematics Dept. of Chemistry and Courant Institute of Mathematical Sciences New York University Topic: Interfacing temperature-accelerated molecular …
  26. CCB Brown Bag Seminar

    Seminar
    1st Presenter: Jamie Morton, Ph.D., Associate Research Scientist, Systems Biology Group Topic: Autism spectrum disorder is a neurodevelopmental disorder that’s characterized by heterogeneous cognitive, behavioral and …
  27. 2021 Fall CCB Colloquia Schedule

    Colloquium
  28. Systems Biology Group Meeting

    Meeting
  29. CCB Seminar: Purushottam Dixit

    Seminar
    Speaker: Purushottam Dixit, Assistant Professor, Department of Physics, Genetics Institute, University of Florida Topic: A novel physics-based dimensionality reduction approach for microbiome data Abstract: Host associated microbiome …
  30. CCB Brown Bag Seminar

    Seminar
    … sequences via computationally expensive simulations. Thus, efficiently exploring the vast protein sequence space still remains a challenge. I will introduce a new method that combines ideas from …
  31. CCB Brown Bag Seminar

    Seminar
    1st Presenter: Reza Farhadifar, Research Scientist, Biophysical Modeling 2nd Presenter: Vladimir Gligorejivic, Ph.D., Research Scientist, Systems Biology
  32. Systems Biology Group Meeting

    Meeting
  33. CCB Brown Bag Seminar

    Seminar
    1st Presenter:  Sonya Hanson, PhD,  Research Scientist & Project Leader for SMB. Topic:  Coiled coils as temperature sensors in voltage-gated sodium channels of marine bacteria Abstract: How biological …
  34. Systems Biology Group Meeting

    Meeting
    Presenter: Daniel Berenberg, Ph.D. Candidate, New York University Topic: Towards scalable protein structural comparison using graph convolutional networks
  35. Drosophila Journal Club

    Meeting
  36. CCB Brown Bag Seminar

    Seminar
    1st presenter: Julien Funk, Senior Software Engineer, Genomics Topic: Applications of Finite State Machines & Statecharts in Software Engineering Abstract: A demonstration of statecharts as used in the context …
  37. Systems Biology Group Meeting

    Meeting
    Presenter: Vlad Gliogorijevic
  38. Systems Biology Group Meeting

    Meeting
    Presenter: Ren Yi, Ph.D. Candidate, New York University Topic: Methods to Improve Knowledge Transfer Efficiency for Data-limited Problems in Genomics Abstract: The recent advancement in computational …
  39. Drosophila Journal Club

    Meeting
    Presenters: Maria Avdeeva & Hayden Nunley Topic: Models for pattern the mammalian Inner Cell Mass (ICM) into Primitive Endoderm and Epiblast
  40. CCB Brown Bag Seminar

    Seminar
    1st presenter: Aidan Daly, PhD, Flatiron Research Fellow, Systems Biology Topic: Bridging the gap between single-cell and spatially resolved -omics Abstract: The development of spatially resolved -omics …
  41. Systems Biology Group Meeting

    Meeting
    Presenter: James Eastwood, Ph.D. Candidate, New York University Title: Static and Dynamic Views of Peptoid Macrocycles in Theory and Experiment Abstract: Cyclic oligomers of N-substituted glycine …
  42. Systems Biology Group Meeting

    Meeting
    Presenter: Jamie Morton, Ph.D., Associate Research Scientist, Systems Biology Group, CCB Title: Towards an autism microbiome consortium study Abstract: In light of the major advances in discovering …
  43. Drosophila Journal Club

    Meeting
    Speaker: Jaspreet Singh Topic: Review of models of cytokinesis
  44. CCB Brown Bag Seminar

    Lecture
    1st presenter: Xi Chen, PhD, Research Scientist, Genomics Topic: High-resolution chromatin accessibility and gene expression data analysis for MRSA/MSSA Abstract: As a pilot study in a …
  45. Systems Biology Group Meeting

    Meeting
    Presenter: Daniel Berenberg Topic: Language modeling for DNA sequences Abstract: Next-generation sequencing efforts have resulted in massive deposits of reliable whole-genome data, namely coding and non …
  46. Systems Biology Group Meeting

    Meeting
    Presenter: Meet Barot, New York University Title: Unsupervised Classification of Proteins Abstract: With the large amount of sequence information constantly being generated, it has become an important problem …
  47. CCB Brown Bag Seminar

    Seminar
    1st Speaker: Tatyana Gavrilchenko, Ph.D., Flatiron Research Fellow, Developmental Dynamics Topic: Fluctuating asymmetries in the wing venation of odonates The intricate wing structure of dragonflies has fascinated …
  48. Systems Biology Group Meeting

    Meeting
    Presenter: Michelle Badri, Ph.D. Candidate, New York University Title: Instrumental variables design for high-dimensional microbiome data Abstract: Instrumental variables estimation is an approach to causal inference …
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