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  • Bringing people and ideas together to fund, conduct, and share transformative science.

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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Systems Biology Group Meeting

    Lecture
  2. Biophysical Modeling Group Meeting

    Meeting
  3. Biophysical Modeling Group Meeting

    Meeting
  4. Brown Bag Seminar

    Lecture
    Topic: Streaming flows in the fruit fly oocyte Abstract: In the cellular phenomena of cytoplasmic streaming, molecular motors carrying cargo along a network of microtubules entrain the surrounding …
  5. Systems Biology Group Meeting

    Lecture
    Presenter: Daniel Berenberg, NYU Topic: Protein structure embeddings through contact map decomposition and convolution Abstract: Protein folds arise from a complex system of atomistic interactions in three dimensions …
  6. Biophysical Modeling Group Meeting

    Lecture
    Article review: Predicting 3d genome folding from DNA sequence
  7. Brown Bag Seminar

    Lecture
    Noémie Globus is a high energy astrophysicist. She has a joint post-doctoral position at the Center for Cosmology and Particle Physics at the New York University and …
  8. Neuroscience Group Meeting

    Meeting
    Speaker: Jingpeng Wu Topic: Comparing different approaches to EM segmentation, followed by a discussion of the pipeline for the wasp connectomics project
  9. Brown Bag Seminar

    Lecture
    Topic: SARS-CoV-2 Viral Genomics and Host Receptor Networks
  10. Neuroscience Group Meeting

    Meeting
    Speaker: Yanis Bahroun Topic: Similarity (mis)matching solves supervised learning problems in the dual. How to make a “Hebbian”-NN out of almost anything.
  11. Brown Bag Seminar

    Lecture
  12. Neuroscience Group Meeting

    Meeting
    Presenter: Siavash Golkar, Ph.D., Research Scientist Topic: Dendritic cortical microcircuits approximate the backpropagation algorithm
  13. CCB Colloquium: Rahul Satija

    Colloquium
    Topic: Integrative analysis of multi-modal single-cell data Abstract: Single-cell RNA-seq has proven to be a transformative tool for the discovery of cell types and …
  14. Brown Bag Seminar

    Lecture
    Topic: Developing Generative Models for Genomics Join from PC, Mac, Linux, iOS or Android: https://simonsfoundation.zoom.us/j/98416432897?pwd=bElRd1N3Z3poSkphNUtONW42cUZ4QT09
  15. Neuroscience Group Meeting

    Meeting
    Speaker: David Lipshutz, Associate Research Scientist Topic: Paper review: A biologically plausible network for multi-component canonical correlation analysis Join from PC, Mac, Linux, iOS or Android: https …
  16. Brown Bag Seminar

    Lecture
    Speaker: Christopher Park, Research Scientist, Genomics Topic: “The impact of RNA-binding protein dysregulation on psychiatric disorder risk.” Join from PC, Mac, Linux, iOS or Android: https://simonsfoundation …
  17. Neuroscience Group Meeting

    Meeting
    Speaker: Kathleen Esfahany Topic: Summary of the Drosophila Hemibrain Connectome and demo of Neuprint interface for accessing data Join from PC, Mac, Linux, iOS or Android: https://simonsfoundation …
  18. Brown Bag Seminar

    Lecture
    Speaker: Vikram Mulligan, Research Scientist, Systems Biology Topic: Advancing the design of peptide therapeutics Join from PC, Mac, Linux, iOS or Android: https://simonsfoundation.zoom.us/j/97373426179 …
  19. Neuroscience Group Meeting

    Meeting
    Speaker: Deena Shefter, Associate Research Analyst Topic: Journal club on the following paper: Network Adaptation Improves Temporal Representation of Naturalistic Stimuli in Drosophila Eye: I Dynamics
  20. Neuroscience Seminar

    Event
    Speaker: Jingpeng Wu, PhD Title: Towards Petabyte Scale Neuron Reconstruction using Deep Learning and Cloud Computing The computation of neural networks is closely related to its connectivity and …
  21. Brown Bag Seminar

    Lecture
    Topic: ‘Visual Circuits and their Variations in a Microscopic Wasp’
  22. Neuroscience Group Meeting

    Meeting
    Speaker: Tiberiu Tesileanu Topic: Online Bayesian time series segmentation: towards neural implementations. Join from PC, Mac, Linux, iOS or Android: https://simonsfoundation.zoom.us/j/98487246580?pwd=ZDFmSFQrSWlndm1sWW1jRWtxZWE4Zz09
  23. Brown Bag Seminar

    Lecture
    Topic: A tale of two systems: Exploring the regulatory landscape of the IBD gut immune system Join from PC, Mac, Linux, iOS or Android: https://simonsfoundation.zoom.us …
  24. Neuroscience Group Meeting

    Meeting
    Speaker: Yanis Bahroun Topic: NeurIPS submission: A neurally plausible minor subspace analyzer balances feedforward excitation and inhibition. Most neural circuits in the brain include inhibitory neurons in various …
  25. 2020 Spring CCB Colloquia Schedule

    Colloquium
  26. Neuroscience Group Meeting

    Meeting
    Zoom Info: Join from PC, Mac, Linux, iOS or Android: https://simonsfoundation.zoom.us/j/732630308 Or Telephone: Dial(for higher quality, dial a number based on your …
  27. Systems Biology Group Meeting

    Meeting
    Speaker: Andreas Tjarnberg
  28. Neuroscience Group Meeting

    Meeting
    Presenter: David Lipshutz, Associate Research Scientist Topic: NeurIPS submission: “Nonnegative Independent Component Analysis” Zoom Info: Join from PC, Mac, Linux, iOS or Android: https://simonsfoundation.zoom.us/j …
  29. Brown Bag Seminar

    Lecture
  30. Systems Biology Group Meetings

    Meeting
    Speaker: Claudia Skok Gibbs
  31. Neuroscience Group Meeting

    Meeting
    Presenters: Charlie Windolf & David Lipshutz Topic: Slow feature analysis Zoom Link Join from PC, Mac, Linux, iOS or Android: https://simonsfoundation.zoom.us/j/732630308
  32. Neuroscience Seminar

    Meeting
    Speaker: Jeffrey C. McGee, PhD Title: Adaptive hippocampal representations generated by a directed synaptic plasticity The seminar will be followed by an informal discussion for anyone interested. Zoom …
  33. Systems Biology Group Meeting

    Meeting
    Speaker: Douglas Renfrew
  34. Neuroscience Group Meeting

    Meeting
    Speaker: Siavash Golkar Topic: NeurIPS submission on biologically plausible Reduced Rank Regression Zoom Info: Join from PC, Mac, Linux, iOS or Android: https://simonsfoundation.zoom.us/j/732630308 …
  35. Brown Bag Seminar

    Lecture
    Topic: Enabling reproducibility through large-scale continuous scientific benchmarks for applications in Rosetta Computational methods should be inherently reproducible. However, changes in the code, input options, and different …
  36. Systems Biology Group Meeting

    Meeting
    Speaker: Anders Rasmussen
  37. 2020 Spring CCB Colloquia Schedule

    Colloquium
  38. Neuroscience Group Meeting

    Meeting
    Topic: NeurIPS submissions Zoom Info: Join from PC, Mac, Linux, iOS or Android: https://simonsfoundation.zoom.us/j/732630308 Or Telephone: Dial(for higher quality, dial a number …
  39. Systems Biology Group Meeting

    Meeting
    Speaker: Sherry Chow
  40. Neuroscience Group Meeting

    Meeting
    Zoom Info: Join from PC, Mac, Linux, iOS or Android: https://simonsfoundation.zoom.us/j/732630308 Or Telephone: Dial(for higher quality, dial a number based on your …
  41. CCB Colloquia: Maria Chikina

    Colloquium
  42. Brown Bag Seminar

    Lecture
    This presentation was pre-recorded. An additional Dropbox link to view the recording will be sent on Monday morning 4/20/20. Please view the talk at your …
  43. Systems Biology Group Meeting

    Meeting
    Speaker: Vikram Mulligan
  44. Neuroscience Group Meeting

    Meeting
    Zoom Info: Join from PC, Mac, Linux, iOS or Android: https://simonsfoundation.zoom.us/j/732630308 Or Telephone: Dial(for higher quality, dial a number based on your …
  45. Systems Biology Group Meeting

    Meeting
    Speaker: Vlad Gliogorijevic
  46. Neuroscience Group Meeting

    Meeting
    Speaker: Shiva GhaaniFarashahi Topic: The role of lateral inhibition in Mushroom Body Link to paper: Localized inhibition in the Drosophila mushroom body Zoom Info: Join from PC, Mac …
  47. Brown Bag Seminar

    Lecture
    Speaker: Julien Funk, Software Engineer, Genomics Topic: HumanBase – data-driven predictions of gene function, regulation and interactions Zoom Info: Join from PC, Mac, Linux, iOS or Android: https …
  48. Systems Biology Group Meeting

    Meeting
    Presenter: Vladimir Gligorijevic, Ph.D., Research Scientist, Systems Biology Group, Center for Computational Biology Topic: Machine learning-guided protein design Computational protein design seeks to create a novel …
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