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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Algebraic Complexity Theory: Where the Abstract and the Practical Meet

    February 24, 2021
    Simons Junior Fellow Jeroen Zuiddam’s studies of algebraic complexity theory illustrate the ongoing effort in computational computer science to solve challenging problems with ease, elegance and efficiency.
  2. SFARI Bridge to Independence Program: Looking Back, Looking Forward

    February 22, 2021
    In this blog, Alice Luo Clayton assesses the first five years of the SFARI Bridge to Independence Award program, the impact the award has had on the fellows …
  3. SFARI Summer 2020 Pilot Awardees Announced

    February 22, 2021
    SFARI is pleased to announce that it intends to fund 19 grants in response to the Summer 2020 Pilot Award request for applications.
  4. SPARK Update: New Phenotypic Data Now Available

    February 19, 2021
    Phenotypic data from 251,082 participants enrolled in SPARK, including more than 99,000 individuals with ASD, are now available to approved researchers.
  5. Astrophysicist Blakesley Burkhart Named a 2021 Sloan Research Fellow

    February 16, 2021
    Blakesley Burkhart, an associate research scientist at the Flatiron Institute’s Center for Computational Astrophysics, has been awarded a 2021 Sloan Research Fellowship by the Alfred P. Sloan …
  6. SFARI Gene: January 2021 Data Release

    February 11, 2021
    New data were recently added to SFARI Gene. This data release included the addition of new genes associated with autism risk, new curated references of copy number variations …
  7. Switching Nanolight On and Off

    February 10, 2021
    Physicists with the Max Planck–New York City Center for Nonequilibrium Quantum Phenomena discover a new way to program light on an ultra-small scale.
  8. Migrating SciComm: From Live to Livestreamed

    February 9, 2021
    Formed in response to the COVID-19 pandemic, the LiveSci Collective supports organizations working to create online science programming
  9. Astrophysicist Rachel Somerville Named a Legacy Fellow of the American Astronomical Society

    February 8, 2021
    The American Astronomical Society (AAS) has inducted Rachel Somerville as a legacy fellow. The honor recognizes her “contributions toward the society’s mission of enhancing and sharing humanity …
  10. Parental Influence on Language Development in Infants at High and Low Risk for Autism

    February 5, 2021
    Charles Nelson, Helen Tager-Flusberg and colleagues assessed language development in infants at high risk and low risk of ASD. They reported parental mean length of utterance as …
  11. Mutations in ACTL6B Are Linked to a Form of Recessive Autism

    February 5, 2021
    Gerald Crabtree, Joseph Gleeson and colleagues defined a new recessive form of ASD caused by mutations in ACTL6B, part of the BAF complex, which regulates activity-responsive transcription …
  12. MeCP2 and VIP-Interneurons

    February 5, 2021
    Jessica Cardin and colleagues identified an important and unexpected role for the VIP subclass of interneurons in mediating the functions of MeCP2 in the development of cortical circuits.
  13. 2021 Simons Fellows in Mathematics and Theoretical Physics Announced

    February 4, 2021
    … University of Colorado, Boulder Hung Tran University of Wisconsin-Madison Gunther Uhlmann University of Washington Jan Wehr University of Arizona Jonathan Wise University of Colorado, Boulder Helen …
  14. CCB and CCM Collaborate To Create the New Structural and Molecular Biophysics Team

    February 4, 2021
    Underlying all biological processes are molecules and their interactions with each other. However, our ability to understand how these molecules function over biologically relevant scales remains very limited …
  15. Simons Searchlight: Research Matching Program Launched

    February 2, 2021
    SFARI is pleased to announce that Simons Searchlight has launched a research matching program, through which researchers can apply to recruit individuals enrolled in Simons Searchlight into new …
  16. Solving the Mystery of a Protein’s Shape

    January 27, 2021
    Using sophisticated techniques and specialized microscopes, Simons Fellow Rosemary Cater has mapped the structure of MFSD2A, a protein residing in the blood-brain barrier that delivers nourishing omega …
  17. Eero Simoncelli Leads New Center for Computational Neuroscience

    January 26, 2021
    … Dmitri Chklovskii will lead the neural circuits and algorithms group, previously part of the Flatiron Institute’s Center for Computational Biology. The group aims to reverse-engineer …
  18. SFARI Bridge to Independence Fellows Discuss New Research Findings and Career Challenges at Virtual Retreat

    January 25, 2021
    Beginning on October 1, 2020, the recipients of the SFARI Bridge to Independence Award gathered with SFARI staff and advisors for a virtual ‘retreat’ of six weekly webinars …
  19. Simons Collaboration on Arithmetic Geometry, Number Theory, and Computation Holds 2021 Annual Meeting Online

    January 22, 2021
    The Simons Collaboration on Arithmetic Geometry, Number Theory, and Computation met remotely on January 19 to provide research highlights from the past year. Director Brendan Hassett provided a …
  20. Marsha Berger Joins CCM As New Group Leader

    January 21, 2021
    We are excited to announce the appointment of Marsha Berger as a new group leader in the Center for Computational Mathematics (CCM) at the Flatiron Institute. Berger is …
  21. Art in and of a Crisis at Science Gallery Detroit

    January 19, 2021
    An innovative mix of online programming, careful design and robot tour guides helps visitors explore Future Present, an exhibition showcasing the impact of design on society
  22. Mathematics Explains How Giant Whirlpools Form in Developing Egg Cells

    January 13, 2021
    The swirling currents occur when the rodlike structures that extend inward from the cells’ membranes bend together like wheat stalks caught in a strong breeze, report researchers at …
  23. 2021 Bridge to Independence Award Request for Applications

    January 11, 2021
    SFARI is pleased to announce the 2021 Bridge to Independence (BTI) Award request for applications. The BTI Award program engages talented early-career scientists in autism research by …
  24. From the bioRxiv: A Selection of Recently Posted Papers From SCPAB Investigators and Others

    January 11, 2021
    Each month, SCPAB scans the bioRxiv and arXiv for interesting papers from the SCPAB community and beyond.
  25. Dutch Research Council Awards 1.1 Million Euros to Neutrino-Hunting PTOLEMY Project

    January 11, 2021
    On November 19, 2020, the Dutch Research Council awarded 1.1 million euros to the PTOLEMY project, which hunts for the barrage of neutrinos emitted a second after …
  26. Announcing Two New Bridge to Independence Awards From SFARI and the Simons Collaboration on the Global Brain

    January 11, 2021
    Requests for applications for these early-career scientist grant opportunities are now open.
  27. SfN Global Connectome: Presentations by SFARI Investigators

    January 8, 2021
    A number of presentations will be given by SFARI Investigators at the SfN Global Connectome: A Virtual Event (January 11–13).
  28. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    January 5, 2021
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  29. The Democratization of Neuroscience

    January 5, 2021
    Broader access to resources and computing tools is changing how neuroscientists research and teach.
  30. Beyond the Sting: Why You Should Start Paying Attention to Wasps

    December 21, 2020
    Behavioral ecologist Patrick Kennedy, a member of the 2021 class of the Simons Society of Fellows, studies why and how wasps choose to cooperate. He finds that paying …
  31. Simons Foundation Selects Astrophysicist David Spergel as Next President

    December 17, 2020
    … truly outstanding people to the foundation and creating a warm and supportive atmosphere that encourages creative and effective work,” Spergel says. “Together, we can maintain the wonderful …
  32. A Conversation With SFARI Investigator Kevin Eggan

    December 15, 2020
    SFARI Investigator Kevin Eggan discusses his research on induced pluripotent stem (iPS) cells and his collaboration with SFARI to provide a detailed characterization of iPS cell lines from …
  33. Simons Collaboration on It From Qubit Holds 2020 Annual Meeting Online

    December 14, 2020
    The Simons Collaboration on It from Qubit met remotely to provide research highlights from the past year. Director Patrick Hayden provided a collaboration overview, while Brian Swingle gave …
  34. Simons Collaboration on Homological Mirror Symmetry Holds 2020 Annual Meeting Online

    December 14, 2020
    The Simons Collaboration on Homological Mirror Symmetry met remotely to provide research highlights from the past year. Director Tony Pantev spoke on Homological Mirror Symmetry and Applications Overview …
  35. Simons Collaboration on the Nonperturbative Bootstrap Holds 2020 Annual Meeting Online

    December 14, 2020
    The Simons Collaboration on the Nonperturbative Bootstrap met remotely to provide research highlights from the past year. Director Leonardo Rastelli provided a collaboration overview, followed by talks by …
  36. SFARI Workshop Discusses Opportunities To Study Maternal Infection and Autism Risk During COVID-19 Pandemic

    December 11, 2020
    On July 29, 2020, SFARI convened an online workshop to explore environmental (maternal and fetal) risk factors for autism spectrum disorder in the context of COVID-19 infection.
  37. The Good Kind of Brainwashing

    December 10, 2020
    Scientists are exploring why the glymphatic system, which helps clear waste from the brain, declines with age — and whether slowing that decline can improve aging.
  38. From the bioRxiv: A Selection of Recently Posted Papers From SCPAB Investigators and Others

    December 8, 2020
    Each month, SCPAB scans the bioRxiv and arXiv for interesting papers from the SCPAB community and beyond.
  39. From the bioRxiv: A Selection of Recently Posted Papers From SCGB Investigators and Others

    December 7, 2020
    Each month, SCGB scans the bioRxiv and arXiv for interesting papers from the SCGB community and beyond.
  40. Unveiling the Forces Behind Millions of Years of Cell Division

    December 1, 2020
    In new research, scientists take a biophysical approach to deciphering the cell’s mysteries.
  41. Simons-NSBP Scholars Program 2021

    November 30, 2020
    The Center for Computational Astrophysics announces a new program that provides undergraduate NSBP members with summer research opportunities.
  42. Beyond Squares and Triangles: Deciphering the Mysteries of Complex Shapes

    November 30, 2020
    By improving understanding of complex shapes, Junior Fellow Aleksander Doan of the Simons Society of Fellows is hoping to inspire advances in physics and geometry.
  43. Role of WNT Signaling in Tbr1-Mutant Phenotypes

    November 19, 2020
    John Rubenstein and colleagues identified WNT signaling as a key mediator of Tbr1-dependent functions in deep-layer cortical neurons, and showed that normalizing WNT signaling rescues particular …
  44. Functional Impact of PTEN Missense Mutations

    November 19, 2020
    Kurt Haas and colleagues used multiple models and bioassays to assess the functional impact of more than 100 missense and nonsense mutations in PTEN, allowing for high-confidence …
  45. Announcement Regarding NASA Hubble Fellowship Program

    November 15, 2020
    The Center for Computational Astrophysics (CCA) is not eligible to host members of the NASA Hubble Fellowship Program, which includes Einstein, Hubble and Sagan fellows. However, we encourage …
  46. Sabbatical Visiting Researcher Program 2021–2022 – Center for Computational Astrophysics

    November 12, 2020
    The Center for Computational Astrophysics (CCA) at the Simons Foundation’s Flatiron Institute is accepting requests from faculty members on sabbatical who are interested in visiting the CCA …
  47. Simons Searchlight: September 2020 Data Release

    November 11, 2020
    New Simons Searchlight data were recently added to SFARI Base. This data release included phenotypic data from individuals with 16p11.2 copy number variants (CNVs), 1q21.1 CNVs …
  48. New Autism BrainNet Website Has Launched

    November 10, 2020
    Autism BrainNet has launched its newly redesigned website. The updated platform has an improved look and feel and new navigation features for a more pleasant, effective and informative …
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