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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Bioengineer Stanislav Shvartsman Heads CCB’s New Developmental Dynamics Group

    November 1, 2019
    The ovaries of female fruit flies contain ovarioles that serve as egg-making assembly lines. This image shows the cross-sections of 10 ovarioles from different fruit flies …
  2. Mystery Solved About the Machines That Move Your Genes

    September 2, 2019
    Congestion causes the mass of tubes and motors that form chromosome-dividing spindles to move at full speed instead of slowing to a crawl, new research reveals.
  3. A Genome-Wide Assessment of Noncoding Risk Variants in Autism

    June 11, 2019
    Olga Troyanskaya, Robert Darnell and colleagues applied deep-learning methods to whole-genome sequencing data from SSC families and identified a clear enrichment for de novo noncoding variation …
  4. New Causes of Autism Found in ‘Junk’ DNA

    May 27, 2019
    The neurodevelopmental condition can result from mutations in the noncoding regions of the human genome, new research demonstrates for the first time.
  5. American Academy of Arts and Sciences Elects Simons-Supported Researchers as 2019 Fellows

    April 18, 2019
    Eleven researchers supported by the Simons Foundation are among the latest batch of prominent leaders in the arts and sciences, business, philanthropy and public affairs, elected as fellows …
  6. How ALS Progresses on Genetic and Cellular Level Revealed by High-Res Spinal Cord Study

    April 4, 2019
    The new findings offer potential avenues for developing therapies for amyotrophic lateral sclerosis.
  7. Michael Shelley Named Director of Center for Computational Biology

    April 1, 2019
    … He holds a B.A. in mathematics from the University of Colorado, Boulder, and a Ph.D. in applied mathematics from the University of Arizona in Tucson …
  8. Open-Source Software Tracks Neural Activity in Real Time

    February 28, 2019
    The tool, called CaImAn, replaces the process of manually tracking the location and activity of neurons.
  9. DNA ‘Dances’ in First Explanation of How Genetic Material Flows Through a Nucleus

    October 25, 2018
    Finding reveals the large-scale movement of genetic material through the nucleus of a working cell.
  10. Particles Surf Their Own Waves, Reveal How Microbes and Cells Move Through Human Body

    September 17, 2018
    New calculations and experiments show how balls ‘catch a wave’ when falling through viscous liquid near a flexible rubber sheet
  11. AI Accurately Predicts Effects of Genetic Mutations in Biological Dark Matter

    July 16, 2018
    The new deep learning technique could help researchers identify the genetic origin of diseases and better understand how evolution shaped our genes
  12. SFARI Announces the Launch of HumanBase

    February 15, 2018
    SFARI announces the launch of HumanBase, a Simons Foundation interactive web server for predictions and information about human genes, pathways and disorders.
  13. Neuropixels Developer James Jun Joins CCB’s Numerical Algorithm Group

    February 8, 2018
    The Flatiron Institute is pleased to announce that Jaeyoon James Jun will join the Center for Computational Biology (CCB) as a postdoctoral fellow with the Numerical Algorithms group.
  14. Pixelated Movies Yield Faster Way To Image Many Neurons

    October 18, 2017
    New analysis techniques can process calcium-imaging data and other types of visual information faster and enable researchers to track larger numbers of neurons.
  15. Spike Sorting Becomes Fully Automated

    October 6, 2017
    A potentially game-changing algorithm eliminates manual sorting in the analysis of neural signals.
  16. Mathematician Alex Barnett Joins CCB as Leader of Numerical Algorithms Group

    October 3, 2017
    The Flatiron Institute is delighted to announce that Alex Barnett has joined the Center for Computational Biology (CCB) as group leader for the Numerical Algorithms group. Barnett is …
  17. Flatiron Scientists — With Help From the Public — Study Connection Between Body Bacteria and Autoimmune Disease

    September 26, 2017
    IBM’s World Community Grid has teamed up with the Flatiron Institute, Broad Institute of MIT and Harvard, Massachusetts General Hospital and the University of California, San Diego.
  18. Gov. Andrew Cuomo Joins Jim and Marilyn Simons to Dedicate Flatiron Institute

    September 7, 2017
    The new institute drives scientific discovery using computational methods.
  19. Flatiron Institute Dedication Ceremony (Video)

    September 7, 2017
    Updated September 22, 2017, with new video. New York Gov. Andrew Cuomo and Simons Foundation co-founders Jim and Marilyn Simons dedicated the Flatiron Institute on September 6 …
  20. CCB’s Olga Troyanskaya Named a Fellow of the International Society for Computational Biology

    February 21, 2017
    Olga Troyanskaya The Simons Foundation congratulates Olga Troyanskaya, who has been selected as an International Society for Computational Biology (ISCB) Fellow in the fellows’ class of 2017. The …
  21. New Tool Predicts Autism Risk Genes

    August 1, 2016
    A computational technique will help scientists to better identify genes, developmental stages of the brain, and cellular functions implicated in the disorder
  22. Big Data Tool to Reveal Immune System Role in Diseases

    September 30, 2015
    Researchers from the Genomics group of the Simons Center for Data Analysis, the Icahn School of Medicine at Mount Sinai and Princeton University have designed a new online …
  23. SCDA’s Richard Bonneau Receives NYU’s Iakobachvili Faculty Science Award

    June 8, 2015
    On June 4, Richard Bonneau of the Simons Center for Data Analysis (SCDA) and New York University (NYU) was presented with NYU’s prestigious Iakobachvili Faculty Science Award …
  24. Olga Troyanskaya Brings Order to Big Data of Human Biology

    April 27, 2015
    … examining large datasets. It aims to address the unsolved mathematical, statistical and computational questions whose resolution will illuminate the underlying science. The center is particularly interested in …
  25. SCDA’s Olga Troyanskaya Works to Understand Genetic Basis of Malignancy

    July 1, 2014
    … understanding of what makes tumors become malignant in humans. When a dog, usually from a nearby shelter, is brought to Sorenmo for treatment, two parallel tumor samples …
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