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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Genomics Group Meeting

    Meeting
  2. SCDG: SIAM CSE Redux Part 2: Andrew Giuliani & Dhairya Malhotra

    Meeting
    10:00 Andrew GiulianiTitle: Weighted state redistribution algorithms on cut cell meshes 10:30 Dhairya MalhotraTitle: High-order boundary integral methods for slender bodies This is Part 2 …
  3. Biophysical Modeling Group Meeting

    Meeting
  4. Developmental Dynamics Group Meeting

    Meeting
  5. Sun-as-a-Star Workshop

    Workshop
    March 13, 2023 Instrument & Data Talks 1 March 13, 2023 Instrument & Data Talks 2 March 13, 2023 Instrument and Data Talks 3 March 14, 2023 Modeling Talks March …
  6. CCA Colloquium: Keaton Bell

    Event
    CCA Colloquium: Keaton Bell Title: An Astrometric and Asteroseismic Synergy for Fundamental White Dwarf Properties Abstract: Pulsating white dwarf stars ring out in multiple simultaneous frequencies that can …
  7. Bayes Reading Group: Bob Carpenter

    Meeting
    Discussion Lead: Bob Carpenter (CCM) Topic: (1) Advances in Black-Box VI: Normalizing Flows, Importance Weighting, and Optimization Abhinav Agrawal, Daniel Sheldon, Justin Domke. 2020. code: https://github …
  8. Cosyne 2023

    Related
    The annual Cosyne meeting provides an inclusive forum for the exchange of empirical and theoretical approaches to problems in systems neuroscience, in order to understand how neural systems …
  9. 2023 Simons Collaboration on Cracking the Glass Problem Annual Meeting

    Conference
    … operators between the eigenstates of the Hamiltonian, and since then, numerous studies have led to the characterization of these objects in increasingly fine detail, providing a solid …
  10. Understanding and Manipulating Immune Modulation by the Microbiome

    Lecture
    Many microbial species colonize animals, with some species benefiting from their hosts without causing any harm. Some of these ‘commensal’ members of the microbiome can elicit a potent …
  11. Systems Biology Group Meeting

    Meeting
  12. Genomics Group Meeting

    Meeting
  13. CCM Colloquium: Erwan Allys (LPENS)

    Event
    Title: Modeling and statistical separation of components in astrophysics Abstract: One of the challenges of astrophysics and cosmology is to study complex non-linear processes from a limited …
  14. Machine Learning at the Flatiron Institute Seminar: Jean Ponce

    Event
    Title: Physical models and machine learning for Photography and Astronomy Abstract: We live in an era of data-driven approaches to image analysis, where modeling is sometimes considered …
  15. Structural & Molecular Biophysics Group Meeting

    Event
  16. SFARI 2023 Human Cognitive and Behavioral Science RFA: Informational session

    Webinar
    On March 7, 2023, SFARI held an informational session about the 2022 Human Cognitive and Behavioral Science request for applications (RFA)
  17. SCDG: SIAM CSE Redux Part 1: Charlie Epstein & Dan Fortunato.

    Event
    10am: Charlie Epstein: Scattering in 2D Open Waveguides. https://meetings.siam.org/sess/dsp_talk.cfm?p=124900 10:30am: Dan Fortunato: Some interesting talks/ideas I saw …
  18. Developmental Dynamics Group Meeting

    Meeting
  19. Bayes Reading Group: Charles Margossian

    Meeting
    Topic: The shrinkage-delinkage trade-off: An analysis of factorized Gaussian approximations for variational inference Abstract: When factorized approximations are used for variational inference (VI), they tend to …
  20. CCB Colloquium: The molecular basis of cellular electricity (Roderick MacKinnon, Ph.D., Laboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, The Rockefeller University)

    Colloquium
    Speaker: Roderick MacKinnon, Ph.D. Laboratory of Molecular Neurobiology and Biophysics, Howard Hughes Medical Institute, The Rockefeller University Title: The molecular basis of cellular electricity Life has exploited …
  21. Testing “Quantumness”

    Lecture
    How can a classical observer (such as a computer) determine that the system with which it is interacting is “truly quantum?” In this talk, Umesh Vazirani will describe …
  22. Systems Biology Group Meeting

    Meeting
  23. CCB Short Course: Intro to Information Theory in Biology

    Meeting
    Lecturer: Henry Mattingly, Associate Research Scientist, Biophysical Modeling In the 1940s, Claude Shannon invented information theory, afundamental tool for quantifying statistical uncertainty andinference. The fact that it deals …
  24. International Quantum Tensor Network: 2nd Plenary Meeting

    Conference
    The second plenary meeting of the International Quantum Tensor Network, which will be hosted by the Flatiron Institute’s Center for Computational Quantum Physics (CCQ) in New York …
  25. CCB Seminar: Wet active matter: Controlling the dynamics of microswimmers (Holger Stark, Ph.D., Technical University of Berlin)

    Meeting
    Speaker: Holger Stark, Ph.D. Institute for Theoretical Physics Technical University of Berlin Title: Wet active matter: Controlling the dynamics of microswimmers Wet active matter refers to microswimmers …
  26. CCQ 2nd Plenary Meeting: International Quantum Tensor Network

    Conference
    March 1, 2023 Iulia Georgescu: How It’s Made: Reviews (and some potentially useful tips) March 1, 2023 Tibor Rakovszky: Dissipation Assisted Approach to the Classical Simulation of …
  27. CCQ Current and Past Quantum Cafe Schedules

    Colloquium
  28. CCQ Workshop Schedule 2023

    Workshop
  29. EMIG Seminar: Machine learning for determining protein structure and dynamics from cryo-EM images (Ellen Zhong, Ph.D., Princeton University)

    Meeting
    Speaker: Ellen Zhong, Ph.D. Assistant Professor, Department of Computer Science Princeton University Title: Machine learning for determining protein structure and dynamics from cryo-EM images Major technological …
  30. Structural & Molecular Biophysics Group Meeting

    Event
  31. Biophysical Modeling Group Meeting

    Meeting
  32. Developmental Dynamics Group Meeting

    Meeting
  33. Some Like It Hot

    In Conversation
    … Institute’s Center for Computational Biology (CCB) in 2021. Her research focuses on structural and molecular biophysics, particularly the modeling and analysis of experimental data and simulations …
  34. CCA Colloquium: Wladimir Lyra

    Lecture
    CCA Colloquium: Wladimir Lyra Title: Dynamical Instabilities in the Aid of Planet Formation in Circumstellar Disks Abstract: During the first million years of evolution, nascent planetary systems are …
  35. Sleep and the Gut

    Lecture
    Sleep is critical to our survival and our very existence: Evidence suggests that even the earliest animals entered sleeplike states. Most efforts to understand the importance of sleep …
  36. Systems Biology Group Meeting

    Meeting
  37. CCB Short Course: Intro to Information Theory in Biology

    Meeting
    Lecturer: Henry Mattingly, Associate Research Scientist, Biophysical Modeling In the 1940s, Claude Shannon invented information theory, afundamental tool for quantifying statistical uncertainty andinference. The fact that it deals …
  38. CCM Colloquium: Nawaf Bou-Rabee (Rutgers University)

    Event
    Title: Adjustable Randomized Time Integrators for Hamiltonian Monte Carlo Abstract: Hamiltonian Monte Carlo is a gradient-based Metropolis-Hastings algorithm with a proposal distribution that involves ceil(T …
  39. Structural & Molecular Biophysics Group Meeting

    Event
  40. Quantum Cafe: John Schotland

    Colloquium
    February 21, 2023 John Schotland: Quantum Optics in Random Media
  41. Biophysical Modeling Group Meeting

    Meeting
  42. Lectures on Diagrammatic Monte Carlo: Diagrammatic Strong Coupling Lattice QMC: a cuprate case (Alexander Lichtenstein)

    Lecture
    … Exchange-correlation effects in a warm dense electron gas (Pengcheng Hou); January 24, 2023: Study of the real frequency dependence of the optical conductivity in the 2D …
  43. Developmental Dynamics Group Meeting

    Meeting
  44. CCA Colloquium: Laura Lopez

    Event
    CCA Colloquium: Laura Lopez Title: The Importance and Challenges of Assessing Stellar Feedback Abstract: Massive stars have a profound astrophysical influence on the interstellar medium (ISM) throughout their …
  45. Seminar Flatiron Institute Seminar Series: SueYeon Chung

    Seminar
    … across different brain areas and task modalities, as demonstrated in our works and others. Finally, we will discuss our recent efforts to fully extend this multi-level …
  46. 2023 Simons Collaboration on Localization of Waves Annual Meeting

    Conference
    … fundamental interest, but it may also find applications in the context of quantum computers. February 16, 2023 Svitlana Mayboroda | Localization of Waves: Director’s Overview (2023) February …
  47. Extreme Control of Light and Sound Waves with Metamaterials

    Lecture
    The field of metamaterials — artificial materials engineered at the nanoscale — has been rapidly evolving in the past two decades, demonstrating extreme wave phenomena and unprecedented control over wave …
  48. Systems Biology Group Meeting

    Meeting
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