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Bringing people and ideas together to fund, conduct, and share transformative science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Ultralight vector dark matter search using data from the KAGRA O3GK run

    Publication
    Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in …
  2. HD152843 b & c: the masses and orbital periods of a sub-Neptune and a superpuff Neptune

    Publication
    We present the characterization of the two transiting planets around HD 152843 (TOI 2319, TIC 349488688) using an intensive campaign of HARPS-N radial velocities, and two sectors …
  3. The OBSIDIAN model: three regimes of black hole feedback

    Publication
    In theoretical models of galaxy evolution, black hole feedback is a necessary ingredient in order to explain the observed exponential decline in number density of massive galaxies. Most …
  4. The baryon cycle in modern cosmological hydrodynamical simulations

    Publication
    In recent years, cosmological hydrodynamical simulations have proven their utility as key interpretative tools in the study of galaxy formation and evolution. In this work, we present a …
  5. Unravelling jet quenching criteria across L* galaxies and massive cluster ellipticals

    Publication
    In the absence of supplementary heat, the radiative cooling of halo gas around massive galaxies (Milky Way mass and above) leads to an excess of cold gas or …
  6. Gas conditions of a star-formation selected sample in the first billion years

    Publication
    We present Atacama Large Millimetre/submillimetre Array (ALMA) observations of the [O III] 88 \(\mu {\rm m}\) emission of a sample of thirteen galaxies at \(z = 6\) to …
  7. Self-similar mass accretion history in scale-free simulations

    Publication
    Using a scale-free N-body simulation generated with the ABACUSN-body code, we test the robustness of halo mass accretion histories via their convergence to self-similarity …
  8. Action and energy clustering of stellar streams in deforming Milky Way dark matter haloes

    Publication
    We investigate the non-adiabatic effect of time-dependent deformations in the Milky Way (MW) halo potential on stellar streams. Specifically, we consider the MW's response to …
  9. Predictions for CO emission and the CO-to-H\(_2\) conversion factor in galaxy simulations with non-equilibrium chemistry

    Publication
    Our ability to trace the star-forming molecular gas is important to our understanding of the Universe. We can trace this gas using CO emission, converting the observed …
  10. All-sky three-dimensional dust density and extinction Maps of the Milky Way out to 2.8 kpc

    Publication
    Three-dimensional dust density maps are crucial for understanding the structure of the interstellar medium of the Milky Way and the processes that shape it. However, constructing these …
  11. Gaia DR3 detectability of unresolved binary systems

    Publication
    Context.Gaia cannot individually resolve very close binary systems; however, the collected data can still be used to identify them. A powerful indicator of stellar multiplicity is the …
  12. A hot-Jupiter progenitor on a super-eccentric retrograde orbit

    Publication
    Giant exoplanets orbiting close to their host stars are unlikely to have formed in their present configurations\(^{1}\). These `hot Jupiter' planets are instead thought to have migrated …
  13. Decomposing Imaginary-Time Feynman Diagrams Using Separable Basis Functions: Anderson Impurity Model Strong-Coupling Expansion

    Publication
  14. KeldyshQFT: A C++ codebase for real-frequency multiloop functional renormalization group and parquet computations of the single-impurity Anderson model

    Publication
  15. Tensor hypercontraction for fully self-consistent imaginary-time GF2 and GWSOX methods: Theory, implementation, and role of the Green’s function second-order exchange for intermolecular interactions

    Publication
  16. Analytic method for quadratic polarons in nonparabolic bands

    Publication
  17. Detector-tuned overlap catastrophe in quantum dots

    Publication
  18. Bridging the small and large in twisted transition metal dichalcogenide homobilayers: A tight binding model capturing orbital interference and topology across a wide range of twist angles

    Publication
  19. Bridging the small and large in twisted transition metal dichalcogenide homobilayers: A tight binding model capturing orbital interference and topology across a wide range of twist angles

    Publication
  20. Detector-tuned overlap catastrophe in quantum dots

    Publication
  21. Analytic method for quadratic polarons in nonparabolic bands

    Publication
  22. Association of behavioural and social-communicative profiles in children with 16p11.2 copy number variants: a multi-site study.

    Publication
  23. Neuronal and behavioral responses to naturalistic texture images in macaque monkeys

    Publication
    The visual world is richly adorned with texture, which can serve to delineate important elements of natural scenes. In anesthetized macaque monkeys, selectivity for the statistical features of …
  24. De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome

    Publication
  25. Expanded clinical phenotype spectrum correlates with variant function in SCN2A-related disorders.

    Publication
  26. Machine learning prediction of autism spectrum disorder from a minimal set of medical and background information.

    Publication
  27. Deciphering missense coding variants with AlphaMissense

    Publication
    … conformations by linking the pairwise correlations from MSA to fold a protein into a correct 3-dimensional structure (directly from Marks et al.4). AlphaFold5 marked a …
  28. Computational tools for cellular scale biophysics

    Publication
    Mathematical models are indispensable for disentangling the interactions through which biological components work together to generate the forces and flows that position, mix, and distribute proteins, nutrients, and …
  29. The roles of sensory hyperreactivity and hyporeactivity in understanding infant fearfulness and emerging autistic traits.

    Publication
  30. Amortized template-matching of molecular conformations from cryo-electron microscopy images using simulation-based inference

    Publication
    Biomolecules undergo conformational changes to perform their function. Cryo-electron microscopy (cryo-EM) can capture snapshots of biomolecules in various conformations. However, these images are noisy and display …
  31. Nested R̂ : Assessing the Convergence of Markov Chain Monte Carlo When Running Many Short Chains

    Publication
    Recent developments in parallel Markov chain Monte Carlo (MCMC) algorithms allow us to run thousands of chains almost as quickly as a single chain, using hardware accelerators such …
  32. Can we constrain warm dark matter masses with individual galaxies?

    Publication
    We study the impact of warm dark matter mass on the internal properties of individual galaxies using a large suite of 1,024 state-of-the-art cosmological …
  33. Zooming in on the Circumgalactic Medium with GIBLE: Tracing the Origin and Evolution of Cold Clouds

    Publication
    We use the GIBLE suite of cosmological zoom-in simulations of Milky Way-like galaxies with additional super-Lagrangian refinement in the circumgalactic medium (CGM) to quantify the …
  34. Cosmology from One Galaxy in a Void?

    Publication
    Understanding galaxy properties may be the key to unlocking some of the most intriguing mysteries of modern cosmology. Recent work relied on machine learning to extract cosmological constraints …
  35. SILVER: Single-loop variance reduction and application to federated learning

    Publication
    Most variance reduction methods require multiple times of full gradient computation, which is time-consuming and hence a bottleneck in application to distributed optimization. We present a single …
  36. Listening to the noise: Blind Denoising with Gibbs Diffusion

    Publication
    In recent years, denoising problems have become intertwined with the development of deep generative models. In particular, diffusion models are trained like denoisers, and the distribution they model …
  37. Learning Associative Memories with Gradient Descent

    Publication
    This work focuses on the training dynamics of one associative memory module storing outer products of token embeddings. We reduce this problem to the study of a system …
  38. Dynamical arrest in active nematic turbulence

    Publication
    Active fluids display spontaneous turbulent-like flows known as active turbulence. Recent work revealed that these flows have universal features, independent of the material properties and of the …
  39. MoMo: Momentum Models for Adaptive Learning Rates

    Publication
    Training a modern machine learning architecture on a new task requires extensive learning-rate tuning, which comes at a high computational cost. Here we develop new Polyak-type …
  40. Identification of novel driver risk genes in CNV loci associated with neurodevelopmental disorders.

    Publication
  41. More data than you want, less data than you need: machine learning approaches to starlight subtraction with MagAO-X

    Publication
    High-contrast imaging data analysis depends on removing residual starlight from the host star to reveal planets and disks. Most observers do this with principal components analysis (i …
  42. Perception and adaptation of receptive prosody in autistic adolescents.

    Publication
  43. Cytoplasmic stirring by active carpets

    Publication
    Large cells often rely on cytoplasmic flows for intracellular transport, maintaining homeostasis, and positioning cellular components. Understanding the mechanisms of these flows is essential for gaining insights into …
  44. Amortized Variational Inference: When and Why?

    Publication
    In a probabilistic latent variable model, factorized (or mean-field) variational inference (F-VI) fits a separate parametric distribution for each latent variable. Amortized variational inference (A-VI …
  45. Discovering the gene-brain-behavior link in autism via generative machine learning.

    Publication
  46. Heavy-Tailed Class Imbalance and Why Adam Outperforms Gradient Descent on Language Models

    Publication
    Adam has been shown to outperform gradient descent on large language models by a larger margin than on other tasks, but it is unclear why. We show that …
  47. Sex-biasing influence of autism-associated Ube3a gene overdosage at connectomic, behavioral, and transcriptomic levels.

    Publication
  48. Charge distribution and helical content tune the binding of septin’s amphipathic helix domain to lipid membranes

    Publication
    Septins are a class of cytoskeletal proteins that preferentially bind to domains of micron-scale curvature on the cell membrane. Studies have shown that amphipathic helix (AH) domains …
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