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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Exploring the Chemical and Climatic Impacts of Solid Particles for Stratospheric Solar Geoengineering

    Funded Work
    This project aims at investigating the chemical and climatic impacts of alternative materials for potential solar radiation management schemes through stratospheric aerosol injections (SAI).
  2. Single Particle Measurements of Aerosols for Informed Solar Radiation Management

    Funded Work
    Stratospheric aerosol injection (SAI) involves delivering particles into the stratosphere to reflect solar radiation, thereby cooling the planet.
  3. Characterising the Global and Regional Impacts and Risks of Alternative Materials for Stratospheric Aerosol Injection

    Funded Work
    Despite the increasing climate risks associated with human-induced warming of the Earth’s surface, there are growing concerns about whether planned greenhouse gas (GHG) emission reductions will …
  4. Laboratory Characterization and Modeling of Stratospheric Aerosol Heterogeneous Chemistry for SAI

    Funded Work
    Understanding and quantifying the stratospheric heterogeneous chemistry of aerosols proposed for use in stratospheric aerosol injection (SAI) is essential for predicting the impact of SAI on stratospheric ozone …
  5. Stratospheric Aerosol Injection from Near-Field to Climate Impact: The Evolution of Aerosol Size Distributions and Agglomerates

    Funded Work
    In a world with steadily increasing atmospheric CO2 concentrations, we will soon have to drastically reduce our emissions to avoid dangerous climate change.
  6. Glaciogenic Seeding on Mixed-Phase Clouds for Radiation Management (GLANCE)

    Funded Work
    This project will use a climate model in different configurations to simulate mixed-phase cloud thinning, a new climate intervention proposal based on seeding supercooled liquid clouds in …
  7. Exploring the Potential for Regionally Cooling the Earth by Seeding Wintertime Mixed-Phase Clouds

    Funded Work
    Worldwide efforts to cut greenhouse gases emissions will likely be insufficient to meet the Paris agreement goal of limiting global warming to 1.5 degrees Celsius.
  8. Constraining the Risks of Alternative SAI Materials via Quantitative Laboratory Experiments

    Funded Work
    By far the most researched form of stratospheric aerosol injection (SAI) is using sulfuric acid/water aerosol or its gas-phase precursors.
  9. Atmospheric Aging Impacts on Particles for Cirrus Cloud Seeding

    Funded Work
    Cirrus cloud thinning is a potential framework to mitigate climate warming via short-lived climate forcers.
  10. First-Principles Physicochemical Characterization of Aerosol Candidates for SAI

    Funded Work
    Stratospheric aerosol injection (SAI) involves the stratospheric injection of sunlight-reflecting aerosols or aerosol precursor gases that ideally possess the following material properties: (i) they do not absorb …
  11. Willie Mae Rock Camp

    Funded Work
    Free music laboratory for girls and gender-expansive youth in NYC that empowers them through transdisciplinary music education
  12. STEM Greenhouse

    Funded Work
    Organization exposing underrepresented students in West Michigan to STEM through interactive, hands-on learning experiences.
  13. STEMcx

    Funded Work
    Organization promoting access for underrepresented students to the skills and information needed to address scientific and technological concerns of their neighborhoods and our changing world.
  14. Sound+Science

    Funded Work
    Innovative after-school program in New York City for high school students interested in exploring the profound connection between music and STEM.
  15. New York Theater Ballet

    Funded Work
    New York City-based theater ballet company integrating dance with quantitative STEM disciplines.
  16. Fundamental Fluid Processes in Climate, Stellar and Planetary Modeling

    Funded Work
    What will the Earth’s atmosphere and oceans look like at the end of the century?
  17. Assessing mRNA translation dysregulation in Gigyf1/2 mouse models of autism

    Funded Work
    Brain development and function require adaptive control of protein synthesis (mRNA translation), which is often disrupted in autism spectrum disorder (ASD).
  18. High-throughput precision gene editing and multi-omics profiling of patient-specific CHD8 variants in human-derived stem cells and induced neurons

    Funded Work
    The tremendous genotypic and phenotypic diversity underlying autism spectrum disorder (ASD) has made it extremely challenging to pinpoint causal mechanisms, distinguish the effects of individual genetic variants, stratify …
  19. Uncovering phenotypic convergence across high-risk autism genes using forebrain assembloids

    Funded Work
    Rare and high-penetrance mutations are key contributors to the risk of autism spectrum disorder (ASD).
  20. Small-scale Experiments for Fundamental Physics

    Funded Work
    If your browser does not automatically load the linked article, please click here.
  21. Ecosystem on the edge: How coastal marsh plants and microbes thrive in an oscillating environment

    Funded Work
  22. Integrated anatomical and gene expression phenotyping in mouse models of autism

    Funded Work
    Genetic disruption of gene-regulatory proteins has emerged as a major underlying cause of autism and related neurodevelopmental disorders (ASD/NDD).
  23. Functionally characterizing genetic variants in the activation domains of autism-associated transcription factors

    Funded Work
    There has been tremendous progress in identifying the genetic basis of autism spectrum disorder (ASD).
  24. Real-time tracking and control of brain neuropeptide levels in a mouse model of autism

    Funded Work
    Dysregulated levels of neuromodulators and other chemical signals may contribute to behavioral characteristics of autism spectrum disorder (ASD).
  25. Quantitative motor phenotyping in nonsyndromic autism and chromatin modifying disorders

    Funded Work
    Delayed or impaired motor development can detrimentally affect environmental exploration, social engagement and spatial perception.
  26. Black Girls Dive Foundation

    Funded Work
    Organization that establishes space and opportunity to empower young ladies to explore their STEM identity through marine science and conservation, and SCUBA diving.
  27. Whiteswan Environmental

    Funded Work
    Native-led non-profit educating and strengthening relationships between bio-regional native and non-native government and NGO’s, as well as academic institutions to reconnect Coast Salish …
  28. The epitranscriptome in the maternal immune activation model of neurodevelopmental conditions

    Funded Work
    Environmental perturbations that disrupt fetal neurodevelopment are strongly associated with autism spectrum disorder (ASD).
  29. Diversity and persistence in plankton communities: Linking models and observations of taxa and trait dynamics

    Funded Work
  30. Annotation of the synaptic interactome and synaptic pathways relevant for autism

    Funded Work
    Large-scale genetic studies are producing valuable new leads to understand disease mechanisms and identify new treatment targets.
  31. Computational phenotyping of individual variation in latent-state learning, generalization and attention across the autism spectrum

    Funded Work
    People with autism spectrum disorder (ASD) often exhibit rigid patterns of behavior, manifesting as difficulty generalizing when encountering a new example of something known or something known in …
  32. Decoding excitation-inhibition imbalance from neuroimaging data in autism

    Funded Work
    Imbalance between excitatory and inhibitory signals in the brain (i.e., E/I imbalance) has long been theorized as one of the primary pathophysiological explanations behind autism.
  33. High-resolution proteome mapping in the developing human cerebral cortex to uncover mutationally convergent pathways in autism

    Funded Work
    Genetic alterations in autism spectrum disorder (ASD) ultimately manifest at the protein level.
  34. Promoting functional brain maintenance – insights from successful agers

    Funded Work
    As we age, our bodies and brains decline.
  35. On the Cosmological and Particle Physics Implications of the String Swampland

    Funded Work
    Cumrun Vafa will seek to find the universal features that distinguish the string landscape from the swampland by studying solutions to string equations.
  36. Prenatal COVID-19 impact on autism risk in genetically susceptible families

    Funded Work
    Increased risk for autism spectrum disorder (ASD) associated with gestational fever, infections, stress and other inflammatory events and innate immune responses and dysregulation suggest the need to study …
  37. Validation of a digital movement-based measure of early social communication

    Funded Work
    Despite commonalities in core social communication traits, young children on the autism spectrum show significant phenotypic heterogeneity and variability in response to interventions focused on improving social communication.
  38. The chemical root of biocatalyst and biosynthetic logic

    Funded Work
  39. Nitrogen fixation and export

    Funded Work
  40. Advancing big data solutions for high volume image data in marine plankton ecology

    Funded Work
  41. Genetics and Artificial Intelligence for Individualized Neural Stratification (GAIINS)

    Funded Work
    Personalized medicine in autism requires stratification biomarkers because of substantial biological heterogeneity.
  42. Identifying early markers of autism in naturalistic motor behavior using high-frequency sampling

    Funded Work
    Early identification of infants at risk for autism spectrum disorder (ASD) is a huge challenge because neither genetic nor neuroimaging methods have revealed robust early pathological markers for …
  43. Long-term ethological monitoring of motor and social behaviors in mouse models of autism

    Funded Work
    Autism spectrum disorder (ASD) is characterized by heterogeneous phenotypes classically encompassing three domains — difficulties with social interactions, language communication challenges and an overrepresentation of stereotyped behaviors.
  44. Validation of an online Neurobehavioral Evaluation Tool (NET) across large autism cohorts

    Funded Work
    Autism spectrum disorder (ASD) is an etiologically and phenotypically heterogenous condition.
  45. Role of autism risk genes in frontal-sensory cognitive control circuits in mice

    Funded Work
    Cognitive control deficits are one of the frequent challenges accompanying autism spectrum disorder (ASD).
  46. Assessing the functions of autism risk genes in deep layer cortical neurons during primate midfetal development

    Funded Work
    The prefrontal cortex (PFC) is critical for a myriad of higher-order brain functions, including working memory, planning, decision-making, language and creative intelligence.
  47. Leveraging computational modeling and data-driven clustering approaches to constrain the heterogeneity of autism phenotypes

    Funded Work
    In this project, Gabriela Rosenblau and colleagues aim to systematically investigate and constrain the heterogeneity of autism spectrum disorder (ASD) by providing a fine-grained mechanistic characterization of …
  48. Electroretinogram activity and peripheral FMRP levels: Correlate biomarkers for fragile X spectrum disorders

    Funded Work
    FMRP is a multifunctional protein essential for normal brain development and neuronal plasticity.
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