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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. A stabilized finite element formulation for simulating ordered arrays of immersed flexible fibers with applications in cellular mechanics

    Publication
    We present a new computational tool for the simulation of aligned assemblies of thin, bendable, but inextensible fibers immersed in a linear Stokes fluid. Such systems are of …
  2. Machine learning-based prediction of peptide aggregation during chemical synthesis

    Publication
    Solid-phase peptide synthesis enables the study of countless peptides, but aggregation during synthesis hinders production of many sequences of interest. Now, machine learning models enable prior identification …
  3. Approximate posterior recalibration

    Publication
    Bayesian inference is often implemented using approximations, which can yield interval estimates that are too narrow, not fully capturing the uncertainty in the posterior distribution. We address the …
  4. Interval timing is altered in male Nrxn1+/- mice: A model of autism spectrum disorder.

    Publication
  5. Temporal and cell-specific regulation of synaptic homeostasis by the chromatin remodeler Chd1.

    Publication
  6. A Network of Biologically Inspired Rectified Spectral Units (ReSUs) Learns Hierarchical Features Without Error Backpropagation

    Publication
    We introduce a biologically inspired, multilayer neural architecture composed of Rectified Spectral Units (ReSUs). Each ReSU projects a recent window of its input history onto a canonical direction …
  7. Contributions of error correction and the spindle assembly checkpoint to mitotic timing and fidelity

    Publication
    Chromosome segregation is a tightly-regulated process that normally occurs with high fidelity. Errors in chromosome segregation are associated with aging, cancer, and infertility. Initially erroneously attached chromosomes …
  8. Geometry of contraction-induced flows

    Publication
    Peristalsis is the driving mechanism behind a broad array of biological and engineered flows. In peristaltic pumping, a wavelike contraction of the tube wall produces local changes in …
  9. Single-cell profiling reveals epithelial and immune responses in BK polyomavirus–infected human kidney biopsies

    Publication
    Single-cell RNA sequencing of human kidney allograft biopsies reveals key transcriptional programs altered during BK polyomavirus infection. We delineate distinct epithelial sub-populations undergoing viral-induced stress …
  10. Linear Readout of Neural Manifolds with Continuous Variables

    Publication
    Brains and artificial neural networks compute with continuous variables such as object position or stimulus orientation. However, the complex variability in neural responses makes it difficult to link …
  11. CryoJAX: a cryo-electron microscopy image-simulation library in JAX

    Publication
    While cryo-electron microscopy (cryo-EM) has come to prominence in the last decade due to its ability to resolve biomolecular complexes at atomic resolution, advancements in experimental …
  12. Diagnosing Generalization Failures from Representational Geometry Markers

    Publication
    Generalization, the ability to perform well beyond the training context, is a hallmark of biological and artificial intelligence, yet anticipating unseen failures remains a central challenge. Conventional approaches …
  13. SPHEREx as a Frontier for Infrared Transients: Classification of New Galactic FU Ori Outbursts and Classical Novae

    Publication
    We demonstrate proof-of-concept of a new strategy for studying infrared (IR) transients enabled by the newly launched SPHEREx space mission, by leveraging its synergy with the …
  14. The Role of Bethe─Heitler Pair Production in Reconnection-driven Flares in M87*

    Publication
    Rapid TeV flares have been observed from the core of the active galaxy M87. These have been attributed to inverse Compton scattering of disk photons by electrons and …
  15. Pulsational Instability of Quasi-stars: Interpreting the Variability of Little Red Dots

    Publication
    The JWST discovery of "Little Red Dots" (LRDs) has revealed a population of compact, red sources at \(z \sim 5-10\) that likely host supermassive black holes (SMBHs …
  16. Fading into Darkness: A Weak Mass Ejection and Low-efficiency Fallback Accompanying Black Hole Formation in M31-2014-DS1

    Publication
    Stellar-mass black holes (BHs) can form from the near-complete collapse of massive stars, causing them to abruptly disappear. The star M31-2014-DS1 in the Andromeda …
  17. Superluminal Wave Activation at Relativistic Magnetized Shocks

    Publication
    Fast radio bursts (FRBs) are extremely energetic radio transients, some are generated in magnetar magnetospheres and winds. Despite a growing number of observations, their emission mechanisms remain elusive …
  18. exoALMA. XXIII. Estimating Disk and Planet Properties from Dust Morphologies with DBNets 2.0

    Publication
    The exoALMA large program provided an unprecedented view of the morphology and kinematics of 15 circumstellar disks, offering a biased but homogenous and well-characterized sample for population …
  19. The Astrometric Resoeccentric Degeneracy: Eccentric Single Planets Mimic 2:1 Resonant Planet Pairs in Astrometry

    Publication
    Detections of long-period giant exoplanets will expand dramatically with Gaia Data Release 4 (DR4), but interpreting these signals will require care. We derive the astrometric resoeccentric degeneracy …
  20. Evidence for a Peak at $\sim$0.3 in the Eccentricity Distribution of Typical Super-Jovian Exoplanets

    Publication
    In this study, we compute completeness-corrected occurrence rates of giant exoplanets as a function of mass, semimajor axis, and eccentricity, using the approximately uniform California Legacy Survey …
  21. A Morphology Catalog of Galaxies in CEERS: Evolution in the Size and Color Gradients of Galaxies Since Cosmic Dawn

    Publication
    We present measurements of morphological parameters from fitting 53,885 galaxies detected to a magnitude limit of F356W
  22. The Hubble Arp Galaxy Survey

    Publication
    The typical galaxy in the local universe is expected to be in a self-regulated quasi-equilibrium, displaying a settled morphology that falls within the Hubble Sequence. The …
  23. Figuring Out Gas & Galaxies in Enzo (FOGGIE). XI. Circumgalactic O VI Emission Traces Clumpy Inflowing Recycled Gas

    Publication
    The circumgalactic medium (CGM) is host to gas flows into and out of galaxies and regulates galaxy growth, but the multiphase, diffuse gas in this region is challenging …
  24. The Milky Way's Circular Velocity Curve Measured Using Element Abundance Gradients

    Publication
    Spectroscopic surveys now supply precise stellar label measurements such as element abundances for large samples of stars throughout the Milky Way. These element abundances are known to correlate …
  25. Magnetic Pressure Dominance Stabilizes AGN Disks against Gravitational Instability

    Publication
    Magnetic effects have long been considered a possible factor in stabilizing the outer regions of active galactic nuclei (AGN) accretion disks against gravitational instability (GI). However, the computational …
  26. The Cosmic Baryon Cycle in IllustrisTNG: Flows of Mass, Energy, and Metals

    Publication
    We measure and analyze the inflows and outflows of mass, energy, and metals through the interstellar medium (ISM) and circumgalactic medium (CGM) of galaxies in the IllustrisTNG100 simulations …
  27. Identifying Compact Chirping SMBHBs in LSST Using Bayesian Analysis

    Publication
    The Legacy Survey of Space and Time (LSST) is expected to observe up to \({\sim}100\) million quasars in the next decade. In this work, we show that …
  28. The Multiwavelength Context of Delayed Radio Emission in Tidal Disruption Events: Evidence for Accretion-driven Outflows

    Publication
    Recent observations presented in Cendes et al. (2024a) show that optically selected tidal disruption events (TDEs) commonly produce delayed radio emission that can peak years post-disruption. Here …
  29. Where Do Stars Explode in the ISM?—The Distribution of Dense Gas around Evolved Massive Stars in M33

    Publication
    The effect of supernovae (SNe) on star-formation in the interstellar medium (ISM) depends sensitively on where SNe explode with respect to ISM clouds. Observationally, SN ISM environments …
  30. Galaxies in the Epoch of Reionization Are All Bark and No Bite—Plenty of Ionizing Photons Low Escape Fractions

    Publication
    Early results from JWST suggest that epoch-of-reionization (EoR) galaxies produce copious ionizing photons, which, if they escape efficiently, could cause reionization to occur too early. We …
  31. Hot Springs and Dust Reservoirs: JWST Reveals the Dusty, Molecular Aftermath of Extragalactic Stellar Mergers

    Publication
    We present James Webb Space Telescope (JWST) observations of four Luminous Red Novae (LRNe): dusty, extragalactic transients from stellar mergers following common-envelope evolution (CEE) in massive binary …
  32. TOI-4495: A Pair of Aligned, Near-resonant Sub-Neptunes That Likely Experienced Overstable Migration

    Publication
    We report the discovery of a sub-Neptune and a Neptune-like planet (Rb=2.48+0.14−0.10R⊕, Rc=4.03+0.23−0.15R⊕) orbiting …
  33. The Milky Way Bulge Extratidal Star Survey: NGC 6569

    Publication
    We present spectroscopic evidence for tidal debris associated with the bulge globular cluster NGC 6569, based on medium-resolution (R ~ 11,000) Anglo-Australian Telescope spectra of 303 …
  34. Tracing AGN feedback power with cool/warm outflow densities: predictions and observational implications

    Publication
    Winds launched at the scale of the accretion disc or dusty torus in Active Galactic Nuclei (AGN) are thought to drive energy-conserving outflows that shape galaxy evolution …
  35. RotCurves: a PYTHON package for efficient modelling and fitting of galactic rotation curves at high-z

    Publication
    Rotation curves are a fundamental tool in the study of galaxies across cosmic time, and with the advent of large integral field unit (IFU) kinematic surveys there is …
  36. AT2019cmw: a highly luminous, cooling featureless TDE candidate from the disruption of a high mass star in an early-type galaxy

    Publication
    We present optical/UV photometric and spectroscopic observations, as well as X-ray and radio follow-up, of the extraordinary event AT2019cmw. With a peak bolometric luminosity of …
  37. Two temperate Earth- and Neptune-sized planets orbiting fully convective M dwarfs

    Publication
    As the diversity of exoplanets continues to grow, it is important to revisit assumptions about habitability and classical HZ definitions. In this work, we introduce an expanded 'temperate …
  38. The supersonic nature of jellyfish galaxies

    Publication
    All gas-rich galaxies in cluster environments are expected to experience ram-pressure stripping from the intra-cluster medium. However, only a fraction of these develop ongoing star …
  39. Radiation magnetohydrodynamics simulations of Population III star formation during the epoch of reionization

    Publication
    Cosmological simulations find that pockets of star-forming gas could remain pristine up until the Epoch of Reionization (EoR) due to the inhomogeneous nature of metal mixing and …
  40. Lense─Thirring precessing magnetar engine drives a superluminous supernova

    Publication
    Type I superluminous supernovae (SLSNe-I) are at least an order of magnitude brighter than standard supernovae, with the internal power source for their luminosity still unknown. The …
  41. A fast algorithm for the wave equation using time-windowed Fourier projection

    Publication
    We introduce a new arbitrarily high-order method for the rapid evaluation of hyperbolic potentials (space-time integrals involving the Green’s function for the scalar wave equation …
  42. Natural Image Statistics, Visual Representation, and Denoising

    Publication
    This article, gathered and elaborated from a lecture by Eero Simoncelli at the 2024 Analytical Connectionism Summer School, reviews several approaches for modeling the probabilistic distribution of natural …
  43. cryoJAX: A Cryo-electron Microscopy Image Simulation Library In JAX

    Publication
    While cryo-electron microscopy (cryo-EM) has come to prominence in the last decade due to its ability to resolve biomolecular complexes at atomic resolution, advancements in experimental …
  44. The head-direction signal is generated by multiple attractor-like networks

    Publication
    While the thalamus is known to relay and modulate sensory signals to the cortex, whether it also participates in active computation and intrinsic signal generation remains unresolved. The …
  45. Emergent Manifold Separability during Reasoning in Large Language Models

    Publication
    Chain-of-Thought (CoT) prompting significantly improves reasoning in Large Language Models, yet the temporal dynamics of the underlying representation geometry remain poorly understood. We investigate these dynamics …
  46. Learning a distance measure from the information-estimation geometry of data

    Publication
    We introduce the Information-Estimation Metric (IEM), a novel form of distance function derived from an underlying continuous probability density over a domain of signals. The IEM is …
  47. Increasing power in language genetics with Lingo: A web-based digital phenotyping platform.

    Publication
  48. Multi-modal tissue-aware graph neural network for in silico genetic discovery

    Publication
    Understanding how perturbations influence gene function in a tissue-specific manner is key to uncovering novel drug targets. However, current computational approaches emphasize global network or sequence-derived …
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