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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Systems Biology Group Meeting

    Meeting
    Speaker: Corey Taylor, Volkamer Lab Topic: QM/MM simulation – Introduction, practicalities and case studies Hybrid quantum mechanics/molecular mechanics (QM/MM) simulations are a popular tool for the …
  2. Biophysical Modeling Group Meeting

    Meeting
    Presenter: Adam Lamson, Ph.D. (Flatiron Research Fellow) Topic: Sticky DNA condensation dynamics Every cell in our body contains all the information of every other cell. However, multicellular …
  3. CCQ Current and Past Quantum Cafe Schedules

    Colloquium
  4. Genomics Group Meeting

    Meeting
  5. CCB Seminar: "A systematic approach for predicting DNA recognition byCys2His2 zinc finger proteins" (Anton Persikov, Ph.D.)

    Seminar
    Speaker: Anton Persikov, Ph.D., Associate Research Scholar, Princeton University Topic: A systematic approach for predicting DNA recognition byCys2His2 zinc finger proteins Cys2His2 zinc finger (ZF) proteins represent …
  6. CCB Seminar: "A systematic approach for predicting DNA recognition byCys2His2 zinc finger proteins" (Anton Persikov, Ph.D.)

    Seminar
    Speaker: Anton Persikov, Ph.D., Associate Research Scholar, Princeton University Topic: A systematic approach for predicting DNA recognition byCys2His2 zinc finger proteins Cys2His2 zinc finger (ZF) proteins represent …
  7. Genomes in Everyday Medicine

    Lecture
    As genomic science becomes a more common partner to the practice of medicine, genomic discoveries in medicine are likely to accelerate. Greater volumes of genome data create new …
  8. Quantum Cafe: Cécile Repellin

    Colloquium
    Title: Fractional Chern Insulators in Magic Angle Twisted Bilayer Graphene Abstract: Layered moire systems have become an outstandingly versatile platform for the study of strongly correlated quantum phenomena …
  9. CCM Colloquium: Justin Domke (UMass Amherst)

    Event
    Title and abstract TBD If you would like to attend, please email [email protected] for the Zoom details.
  10. FI Computational Methods and Data Science Journal Club: Miles Cranmer

    Seminar
    FI Computational Methods and Data Science Journal Club Flatiron Institute, 162 5th Avenue Speaker: Miles Cranmer (CCA/Princeton) Title: Interpretable Machine Learning for Science Abstract: Would Kepler have …
  11. CCB Colloquium: "Protein Structure Prediction in a Post-Alpha2 World" (Mohammed AlQuraishi, Ph.D.)

    Colloquium
    Speaker: Mohammed AlQuraishi Assistant Professor of Systems Biology (in Computer Science) Department Systems Biology Title: Protein structure prediction in a post-AlphaFold2 world AlphaFold2 burst on the life …
  12. Developmental Dynamics Group Meeting

    Meeting
  13. Systems Biology Group Meeting

    Meeting
  14. Biophysical Modeling Group Meeting

    Meeting
  15. Workshop: From Data to Software to Science with the Rubin Observatory LSST

    Workshop
    … What we have learned, assignments and next steps
  16. CCA Colloquium: Jillian Bellovary

    Event
    CCA Colloquium: Jillian Bellovary Title: Seeking Massive Black Holes in Dwarf Galaxies Abstract: Recent discoveries of massive black holes in dwarf galaxies suggest that they may have a …
  17. CCB Seminar: Taeyoon Kim, Ph.D. (Purdue University): Reconstructing the Mechanical and Dynamic Behaviors of Cells in Silico

    Seminar
    Presenter: Taeyoon Kim, Associate Professor Purdue University, Weldon School of Biomedical Engineering Topic: Reconstructing the Mechanical and Dynamic Behaviors of Cells in Silico Actin cytoskeleton is a dynamic …
  18. CCB Seminar: "Reconstructing the Mechanical and Dynamic Behaviors of Cells in Silico" (Taeyoon Kim, Ph.D.)

    Seminar
    Speaker: Taeyoon Kim, Ph.D. Assistant Professor, Purdue University Title: Reconstructing the Mechanical and Dynamic Behaviors of Cells in Silico Actin cytoskeleton is a dynamic structural scaffold used …
  19. Bayes Reading Group: Leonardo Egidi

    Meeting
    Discussion Lead: Leonardo Egidi Topic: A Bayesian fairy tale: the mysteries of the mixtures. Priors, likelihoods and other ‘multi-headed’ monsters The Bayesian model consists of the prior …
  20. CCB Colloquium: "Multiscale Modeling of dementia: from proteins to cognitive functions" (Alain Goriely, Ph.D.)

    Colloquium
    Speaker: Alain Goriely, Ph.D. Title: Multiscale modeling of dementia: from proteins to cognitive functions Neurodegenerative diseases such as Alzheimer’s or Parkinson’s are devastating conditions with …
  21. Genomics Group Meeting

    Meeting
  22. Simons Collaboration on Hidden Symmetries and Fusion Energy Annual Meeting 2022

    Conference
    … extend the existing physics optimization tools of SIMSOPT with code capabilities that capture engineering and manufacturing aspects of stellarator fusion power plants to enable swift and low …
  23. Computational Microscopy

    Lecture
    Computational imaging involves the joint design of imaging system hardware and software, optimizing the entire pipeline from acquisition to reconstruction. Computers can replace bulky and expensive optics by …
  24. Quantum Cafe: Steve Kivelson

    Colloquium
    Title: Superconductivity in the Hubbard Model Abstract: Since the discovery of high temperature superconductivity in the cuprates, much of the discussion concerning the mechanism of unconventional superconductivity in …
  25. CCM Colloquium: Bruno Regaldo-Saint Blancard (CCM)

    Event
    Title: Describe and model without learning using wavelet scattering-like statistics: an application to Galactic dust emission In Cosmology, the emission of interstellar dust is a main obstacle …
  26. LCV Lab Meeting: COSYNE Recap

    Meeting
  27. IDEA Scholar Lecture: "Ageing men, their selfish testes, new mutations and human disease" (Anne Goriely, Ph.D.)

    Colloquium
    Speaker: Anne Goriely, Ph.D. Title: “Ageing men, their selfish testes, new mutations and human disease” Abstract: Because mutations are at the origin of all genetic variations, understanding …
  28. FI Computational Methods and Data Science Journal Club: Domenico DiSante

    Seminar
    FI Computational Methods and Data Science Journal Club Flatiron Institute, 162 5th Avenue Speaker: Domenico DiSante (CCQ) Title: Deep Learning the Functional Renormalization Group Flow for Correlated Fermions …
  29. IDEA Scholar Lecture: "Ageing men, their selfish testes, new mutations and human disease" (Anne Goriely, Ph.D.)

    Colloquium
    Speaker: Anne Goriely, Ph.D. Title: “Ageing men, their selfish testes, new mutations and human disease” Abstract: Because mutations are at the origin of all genetic variations, understanding …
  30. Developmental Dynamics Group Meeting

    Meeting
  31. Systems Biology Group Meeting

    Meeting
    Speaker: Corey Taylor, Volkamer Lab Topic: QM/MM simulation – Introduction, practicalities and case studies Hybrid quantum mechanics/molecular mechanics (QM/MM) simulations are a popular tool for the …
  32. The Joy of Wh(y) with Steven Strogatz

    In Conversation
    … serves as a board member on the Council for the Advancement of Science Writing.
  33. CCA Colloquium: Marc Kamionkowski

    Event
    CCA Colloquium: Marc Kamionkowski Title: Forays with a Formidable Formalism: Total Angular Momentum Waves, Cosmological Perturbations, and Gravitational Waves. Abstract: Ten years ago, Liang Dai, Donghui Jeong, and …
  34. Bayes Reading Group: Richard Lange

    Meeting
    Discussion Lead: Richard Lange (UPenn) Topic: Interpolating between sampling and variational inference with infinite stochastic mixtures. Link: https://arxiv.org/abs/2110.09618 Open Review version: https://openreview …
  35. Genomics Group Meeting

    Meeting
  36. CCB Seminar: Rogerio Feris, Ph.D. Rogerio Feris, Ph.D. (IBM T.J. Watson Research Center): Computational Visual Pathways for Multi-Task Learning and Simulation

    Seminar
    Presenter: Rogerio Feris, Research Manager (Computer Vision), Master Inventor (IBM T. J. Watson Research Center) Topic: Computational Visual Pathways for Multi-Task Learning and Simulation In this talk …
  37. Computational and Systems Neuroscience (Cosyne) 2022

    Related
    The annual Cosyne meeting provides an inclusive forum for the exchange of empirical and theoretical approaches to problems in systems neuroscience, in order to understand how neural systems …
  38. Simons Society of Fellows Retreat 2022

    Conference
    … steady-state and inflammatory conditions; however, the mechanisms are not understood. The gastrointestinal (GI) tract is the largest barrier surface where the body is exposed to the …
  39. CCM Colloquium: Andreas Rosen (Remote talk)

    Event
    Title: Dirac Integral equations, plasmonics and eddy currents Abstract: A well-known problem in Maxwell scattering is how to handle the divergence-free constraints on the fields. We …
  40. FI Computational Methods and Data Science Journal Club: SueYeon Chung

    Seminar
    … badge) please email [email protected] to be registered to the building or to obtain Zoom information. All visitors must be vaccinated for entry into our buildings.
  41. CCB Seminar: Weiguang Mao, Ph.D. (University of Pittsburgh): Generative Models of Biological Variations in Bulk and Single-cell RNA-seq

    Seminar
    Presenter: Weiguang Mao, Ph.D. ( University of Pittsburgh) Topic: Generative Models of Biological Variations in Bulk and Single-cell RNA-seq The explosive growth of transcriptomic profiling has …
  42. Global Postdoc/Student Meeting

    SCGB
    The Simons Collaboration on the Global Brain hosts a Global group meeting to bring together postdocs and PhD students interested in neural coding and dynamics to discuss ideas …
  43. Developmental Dynamics Group Meeting

    Meeting
  44. Systems Biology Group Meeting

    Meeting
  45. Biophysical Modeling Group Meeting

    Meeting
  46. Flatiron Institute Seminar Series: Pilar Cossio

    Lecture
    Title: Challenges and solutions to unravel the molecular mechanisms of proteins Abstract: Proteins are nano-sized biomachines that perform most of our vital functions. For example, proteins convert …
  47. Genomics Group Meeting

    Meeting
  48. FRF Candidate Lecture: Sarah Harveys

    Event
    Please save the date and welcome FRF Candidate, Sarah Harvey, Stanford University who will be presenting on March 10th at 10:30AM in the 4th Floor Classroom at …
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