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Drugs that target pre-mRNA splicing hold great therapeutic potential, but the quantitative understanding of how these drugs work is limited. Here we introduce mechanistically interpretable quantitative models …

Separating signals from an additive mixture may be an unnecessarily hard problem when one is only interested in specific properties of a given signal. In this work, we …

The study of the brain encompasses multiple scales, including temporal, spatial, and functional aspects. To integrate understanding across these different levels and modalities, it requires developing quantification methods …

NOVA1 is a neuronal RNA-binding protein identified as the target antigen of a rare autoimmune disorder associated with cancer and neurological symptoms, termed paraneoplastic opsoclonus-myoclonus ataxia …

As the size and ubiquity of artificial intelligence and computational machine learning models grow, the energy required to train and use them is rapidly becoming economically and environmentally …

Most leading implementations of black-box variational inference (BBVI) are based on optimizing a stochastic evidence lower bound (ELBO). But such approaches to BBVI often converge slowly due …

Many recent works have studied the eigenvalue spectrum of the Conjugate Kernel (CK) def ined by the nonlinear feature map of a feedforward neural network. However, existing results …

Protein–protein interactions (PPIs) drive cellular processes and responses to environmental cues, reflecting the cellular state. Here we develop Tapioca, an ensemble machine learning framework for studying global …

We present a dedicated transit and radial velocity survey of planets orbiting subgiant stars observed by the TESS Mission. Using \(\sim 16\) nights on Keck/HIRES, we confirm …

In the fruit fly Drosophila melanogaster, two cells in a cyst of 16 interconnected cells have the potential to become the oocyte, but only one of these will …

Standard Markov chain Monte Carlo (MCMC) admits three fundamental control parameters: the number of chains, the length of the warmup phase, and the length of the sampling phase …

This work concerns the design of perfectly conducting objects that are invisible to an incident transverse magnetic plane wave. The object in question is a finite planar waveguide …

Rapid advances in deep learning have brought not only myriad powerful neural networks, but also breakthroughs that benefit established scientific research. In particular, automatic differentiation (AD) tools and …

In protoplanetary disks, sufficiently massive planets excite pressure bumps, which can then be preferred locations for forming new planet cores. We discuss how this loop may affect the …

We confirm TOI-4201 b as a transiting Jovian mass planet orbiting an early M dwarf discovered by the Transiting Exoplanet Survey Satellite. Using ground based photometry and …

ars formed with initial mass over 50 Msun are very rare today, but they are thought to be more common in the early universe. The fates of those …

Under the assumption of a simple and time-invariant gravitational potential, many Galactic dynamics techniques infer the Milky Way's mass and dark matter distribution from stellar kinematic …

Stellar streams form through the tidal disruption of satellite galaxies or globular clusters orbiting a host galaxy. Globular cluster streams are exciting since they are thin (dynamically cold …

We use James Webb Space Telescope Near-Infrared Camera Wide Field Slitless Spectroscopy (NIRCam WFSS) and the Near-Infrared spectrograph (NIRSpec) in the Cosmic Evolution Early Release survey …

One of the open questions following the discovery of GW170817 is whether neutron star (NS) mergers are the only astrophysical sites capable of producing r-process elements. Simulations …

We demonstrate how to constrain the degree of absolute alignment of the total angular momenta of LIGO–Virgo binary black holes, looking for a special direction in space …

We are entering an era in which we will be able to detect and characterize hundreds of dwarf galaxies within the Local Volume. It is already known that …

The abundance of bright galaxies at z>8 can provide key constraints on models of galaxy formation and evolution, as the predicted abundance varies greatly when different physical …

We present cosmological constraints from a gravitational lensing mass map covering 9400 deg\(^{2}\) reconstructed from measurements of the cosmic microwave background (CMB) made by the Atacama Cosmology …

We present new measurements of cosmic microwave background (CMB) lensing over 9400 deg\(^{2}\) of the sky. These lensing measurements are derived from the Atacama Cosmology Telescope (ACT …

We use data from the Atacama Cosmology Telescope (ACT) DR4 to search for the presence of neutrino self-interaction in the cosmic microwave background. Consistent with prior works …

The disruption of a star by the tidal forces of a spinning black hole causes the stellar stream to precess affecting the conditions for triggering the tidal disruption …

The upcoming Nancy Grace Roman Space Telescope will carry out a wide-area survey in the near-infrared. A key science objective is the measurement of cosmic structure …

A galaxy cluster as the most massive gravitationally bound object in the Universe, is dominated by dark matter, which unfortunately can only be investigated through its interaction with …

The second data release of ESA's \(Gaia\) mission revealed numerous signatures of disequilibrium in the Milky Way's disc. These signatures are seen in the planar kinematics …

Young stellar objects (YSOs) are the gold standard for tracing star formation in galaxies but have been unobservable beyond the Milky Way and Magellanic Clouds. But that all …

Observational studies are finding stars believed to be relics of the earliest stages of hierarchical mass assembly of the Milky Way (i.e., proto-Galaxy). In this work …

Galaxies comprise intricate networks of interdependent processes which together govern their evolution. Central among these are the multiplicity of feedback channels, which remain incompletely understood. One outstanding problem …

Observations of local star-forming galaxies (SFGs) show a tight correlation between their singly ionized carbon line luminosity (\(L_{\rm [C_{II}]}\)) and star formation rate (SFR), suggesting …

We report the discovery of TOI-4641b, a warm Jupiter transiting a rapidly rotating F-type star with a stellar effective temperature of 6560 K. The planet has …