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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Mathematics of Deep Learning Seminar: Yi Ma

    Seminar
    Title: Deep (Convolution) Networks from First Principles Abstract: In this talk, we offer an entirely “white box’’ interpretation of deep (convolution) networks from the perspective of data compression …
  2. Lectures on Diagrammatic Monte Carlo: Beyond Hubbard model: charge order and non-local correlations in extended Hubbard model (Hanna Terletska)

    Lecture
    All lectures in this series will be held 10-11:15am US EDT and are open to all interested scientists. For further information please contact Dr. Igor Tupitsyn …
  3. 7th Annual BRAIN Initiative Investigators Meeting

    Related
    The BRAIN Initiative Investigators Meeting convenes BRAIN Initiative awardees, staff, and leadership from the contributing federal agencies (NIH, NSF, DARPA, IARPA, and FDA), plus representatives and investigators from …
  4. Bayes Reading Group: Bob Carpenter

    Meeting
    Discussion Lead: Bob Carpenter, CCM Topic: Robust, Accurate Stochastic Optimization for Variational Inference. 2020. Akash Kumar Dhaka, Alejandro Catalina, Michael Riis Andersen, Måns Magnusson, Jonathan H. Huggins, Aki …
  5. West Coast Postdoc / Student Meeting

    SCGB
    The Simons Collaboration on the Global Brain hosts a West Coast group meeting to bring together postdocs and PhD students interested in neural coding and dynamics. This month …
  6. Mathematics of Deep Learning Seminar: Sanjeev Arora

    Seminar
    Title: Trajectory, Trajectory, Trajectory Abstract: As we begin to “open the black box” of deep learning, it becomes clear that many important phenomena can only be understood via …
  7. Systems Biology Group Meeting

    Meeting
    Presenter: Daniel Berenberg, Ph.D. Candidate, New York University Topic: Towards scalable protein structural comparison using graph convolutional networks
  8. Biophysical Modeling Group Meeting

    Meeting
    Presenter: Alex Rautu, Ph.D. Topic: Active Nuclear Transport in Living Cells
  9. Neurodegenerative Diseases: Genes, Mechanisms and Therapeutics

    Related
    This conference aims to provide an integrated discussion of the latest advances in research and therapeutic development for neurodegenerative diseases. This conference program will focus on the roles …
  10. NeuroImmune Interactions in Health and Disease

    Related
    The emerging field of neuroimmunology is one of the most exciting and fastest moving areas in biomedical research. Communication between the brain and the immune system play critical …
  11. Drosophila Journal Club

    Meeting
  12. Bayes Reading Group: Pilar Cossio

    Meeting
    Discussion Lead: Pilar Cossio, CCB/CCM Topic: Transition path sampling and the calculation of rate constants Paper: https://doi.org/10.1063/1.475562 Please email Sara Mejias …
  13. Moiré Materials Group Meeting

    Meeting
    Speaker: Dmitri Efetov June 3, 2021 Dmitri Efetov: Magic Angle Bilayer Graphene – Superconductors, Correlated States, Orbital Magnets and Beyond…
  14. CCM Seminar: Shariq Mohammed

    Seminar
    Title: “Radiohead: Radiogenomic analysis incorporating tumor heterogeneity in imaging through densities” Abstract: Recent technological advancements have enabled detailed investigation of associations between the molecular architecture and tumor heterogeneity …
  15. CCB Brown Bag Seminar

    Seminar
    1st presenter: Julien Funk, Senior Software Engineer, Genomics Topic: Applications of Finite State Machines & Statecharts in Software Engineering Abstract: A demonstration of statecharts as used in the context …
  16. Quantum Cafe Webinar: Abhay Pasupathy

    Colloquium
    Title: Twistons in the Magic Sea Abstract: The latest entry into the moiré graphene family is twisted trilayer graphene. This material consists of three sheets of graphene, and …
  17. CCQ Current and Past Quantum Cafe Schedules

    Colloquium
  18. Mathematics of Deep Learning Seminar Schedule

    Seminar
  19. Mathematics of Deep Learning Seminar: Leon Bottou

    Seminar
    Title: Learning Representations Using Causal Invariance Abstract: Learning algorithms often capture spurious correlations present in the training data distribution instead of addressing the task of interest. Such spurious …
  20. Lectures on Diagrammatic Monte Carlo: Superfluid phase of the attractive Hubbard model (Felix Werner)

    Lecture
    All lectures in this series will be held 10-11:15am US EDT and are open to all interested scientists. For further information please contact Dr. Igor Tupitsyn …
  21. Transylvanian Experimental Neuroscience Summer School (TENSS) 2020

    Related
    UPDATE: This event has been postponed to June 2021. Stay tuned for more information. TENSS concentrates top-level international expertise to teach a dozen students techniques and concepts …
  22. CCQ Current and Past Workshop Schedules

    Workshop
  23. Systems Biology Group Meeting

    Meeting
    Presenter: Vlad Gliogorijevic
  24. Bayes Reading Group: Lu Zhang

    Meeting
    Discussion Lead: Lu Zhang, Columbia University Topic: Hoffman, Ma. Black-Box Variational Inference as a Parametric Approximation to Langevin Dynamics. ICML 2020. Paper: http://proceedings.mlr.press/v119 …
  25. Mathematics of Deep Learning Seminar: Tom Goldstein

    Seminar
    Title: Breaking Machine Learning Systems at the Industrial Scale Abstract: Evasion and poisoning attacks have been demonstrated on a range of systems, but usually in a simplified laboratory …
  26. Innovators in Neuroscience: From Molecules to Mind

    Related
    Columbia’s Zuckerman Institute and Mount Sinai’s Friedman Brain Institute present Innovators in Neuroscience: From Molecules to Mind, a virtual symposium highlighting recent advances from basic to …
  27. Biophysical Modeling Group Meeting

    Meeting
  28. Biophysics & Development Seminar: Tsvi Tlusty, Ulsan National Institute of Science and Technology

    Seminar
    Presenter: Tsvi Tlusty, Ph.D., , Ulsan National Institute of Science and Technology Topic: Protein: the physics of amorphous evolving matter
  29. Systems Biology Group Meeting

    Meeting
    Presenter: Ren Yi, Ph.D. Candidate, New York University Topic: Methods to Improve Knowledge Transfer Efficiency for Data-limited Problems in Genomics Abstract: The recent advancement in computational …
  30. DNA and Cold Cases: From Crime Scene to Courtroom

    Lecture
    TV shows like CSI give viewers a glimpse of how investigators solve crimes using DNA and other forensic tools, all wrapped up in an hour. What these shows …
  31. Big Apple Colloquium: Karin Öberg

    Colloquium
    Title: Astrochemistry and the Compositions of Planets Abstract: Planets form in disks around young stars. The resulting planet compositions are intimately linked to the disk chemical structures; the …
  32. Drosophila Journal Club

    Meeting
    Presenters: Maria Avdeeva & Hayden Nunley Topic: Models for pattern the mammalian Inner Cell Mass (ICM) into Primitive Endoderm and Epiblast
  33. What do we mean by ‘autism risk genes’?

    Lecture
    David Ledbetter and Joseph Buxbaum discussed whether there are genes for which mutations confer risk specific to autism or whether these genes are really conferring general risk of …
  34. Bayes Reading Group: Bob Carpenter

    Meeting
    Discussion Lead: Bob Carpenter, CCM Topic: Piponi, Hoffman, Sountsov. Hamiltonian Monte Carlo Swindles. AISTATS 2020. Paper: http://proceedings.mlr.press/v108/piponi20a/piponi20a.pdf Please email Sara Mejias …
  35. Vision Sciences Society Annual Meeting

    Related
    The scientific content of the meeting reflects the breadth of topics in modern vision science, from visual coding to perception, recognition and the visual control of action, as …
  36. SFARI 2021 Genomics of ASD: Pathways to Genetic Therapies RFA — Informational session

    Webinar
    The SFARI science team held an informational session to answer questions about the 2021 Genomics of ASD: Pathways to Genetic Therapies request for applications.
  37. Moire Materials Group Meeting

    Meeting
    Speaker: Gregory Polshyn May 20, 2021 Gregory Polshyn: Orbital Chern Insulators in Flat-band Graphene Moiré Systems
  38. Simons-Emory Theory Methods Workshop

    Related
    On Day 1 (5/19), Gordon Berman;.’s group will discuss methods for quantifying, analyzing, and modeling animal behavior in the context of neuroscientific experiments. On Day 2 …
  39. DevDy Group Meeting

    Meeting
  40. Boston-Area Postdoc/Student Meeting

    SCGB
    The Simons Collaboration on the Global Brain hosts a Boston-area group meeting to bring together postdocs and PhD students interested in neural coding and dynamics. This month …
  41. CCB Brown Bag Seminar

    Seminar
    1st presenter: Aidan Daly, PhD, Flatiron Research Fellow, Systems Biology Topic: Bridging the gap between single-cell and spatially resolved -omics Abstract: The development of spatially resolved -omics …
  42. Quantum Cafe Webinar: James Analytis

    Colloquium
    Title: Superconductivity and quantum criticality linked by the Hall effect in a strange metal Abstract: Many unconventional superconductors exhibit a common set of anomalous charge transport properties that …
  43. Mathematics of Deep Learning Seminar: Bin Yu

    Seminar
    Title: Disentangled interpretations for deep learning with ACD Abstract: Recent deep learning models have achieved impressive predictive performance by learning complex functions of many variables, often at the …
  44. Lectures on Diagrammatic Monte Carlo: Diagrammatic Monte Carlo solutions to some longstanding problems (Aaram Kim)

    Lecture
    All lectures in this series will be held 10-11:15am US EDT and are open to all interested scientists. For further information please contact Dr. Igor Tupitsyn …
  45. Biophysical Modeling Group Meeting

    Meeting
    Presenter: Aleksandra Plochocka, Ph.D., Research Fellow Topic: “Interplay of E-cadherin and actomyosin in tissue mechanics”
  46. Systems Biology Group Meeting

    Meeting
    Presenter: James Eastwood, Ph.D. Candidate, New York University Title: Static and Dynamic Views of Peptoid Macrocycles in Theory and Experiment Abstract: Cyclic oligomers of N-substituted glycine …
  47. Biophysics & Development Seminar: Anna Kreshuk, EMBL

    Lecture
    Title: Single cells in a whole organism: image analysis to prepare the ground Abstract: Cutting-edge volume electron microscopy allows to image very large samples, up to the …
  48. Tiling Space and Making Hard Problems Harder

    Lecture
    A shape can tile space if we can take infinitely many copies of the shape and shift them around to cover every point without overlapping. For example, squares …
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