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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Characterizing out-of-distribution generalization of neural networks: application to the disordered Su-Schrieffer-Heeger model

    Publication
  2. Nonperturbative Nonlinear Transport in a Floquet-Weyl Semimetal

    Publication
  3. Deconstructing the Goldilocks Zone of Neural Network Initialization

    Publication
  4. Topological superconductivity from repulsive interactions in twisted WSe

    Publication
  5. Efficiency of neural quantum states in light of the quantum geometric tensor

    Publication
  6. Cavity Spectroscopy for Strongly Correlated Systems

    Publication
  7. Monte Carlo Methods in the Manifold of Hartree-Fock-Bogoliubov Wave Functions

    Publication
  8. Photon Many-body Dispersion: an Exchange-correlation Functional for Strongly Coupled Light-matter Systems

    Publication
  9. The Emotion Dysregulation Inventory-Young Child: Psychometric properties and item response theory calibration in 2- to 5-year-olds.

    Publication
  10. Simulating Polaritonic Ground States on Noisy Quantum Devices

    Publication
  11. Ab Initio Calculations of Quantum Light–Matter Interactions in General Electromagnetic Environments

    Publication
  12. Classical Shadows for Quantum Process Tomography on Near-term Quantum Computers

    Publication
  13. Efficient Tensor Network Simulation of IBM’s Eagle Kicked Ising Experiment

    Publication
  14. Magnetism and metallicity in moirè transition metal dichalcogenides

    Publication
  15. Stochastic Optimal Control Matching

    Publication
    Stochastic optimal control, which has the goal of driving the behavior of noisy systems, is broadly applicable in science, engineering and artificial intelligence. Our work introduces Stochastic Optimal …
  16. Learning High-Dimensional McKean–Vlasov Forward-Backward Stochastic Differential Equations with General Distribution Dependence

    Publication
    One of the core problems in mean-field control and mean-field games is to solve the corresponding McKean–Vlasov forward-backward stochastic differential equations (MV-FBSDEs). Most …
  17. Directional Smoothness and Gradient Methods: Convergence and Adaptivity

    Publication
    We develop new sub-optimality bounds for gradient descent (GD) that depend on the conditioning of the objective along the path of optimization, rather than on global, worst …
  18. Adaptive micro-locomotion in a dynamically changing environment via context detection

    Publication
    Substantial efforts have exploited reinforcement learning (RL) in the development of micro-robotic locomotion. These RL-powered micro-robots are capable of learning a locomotory policy based on …
  19. Hydrodynamics of a multicomponent vesicle under strong confinement

    Publication
    We numerically investigate the hydrodynamics and membrane dynamics of a multicomponent vesicle in two strongly confined geometries. This serves as a simplified model for red blood cells undergoing …
  20. Re-consenting pediatric research participants as legal adulthood approaches: Lessons from the SPARK autism study.

    Publication
  21. Uniform approximation of common Gaussian process kernels using equispaced Fourier grids

    Publication
    The high efficiency of a recently proposed method for computing with Gaussian processes relies on expanding a (translationally invariant) covariance kernel into complex exponentials, with frequencies lying on …
  22. A new provably stable weighted state redistribution algorithm

    Publication
    We propose a practical finite volume method on cut cells using state redistribution. Our algorithm is provably monotone, total variation diminishing, and GKS (Gustafsson, Kreiss, Sundström) stable in …
  23. A new version of the adaptive fast Gauss transform for discrete and continuous sources

    Publication
    We present a new version of the fast Gauss transform (FGT) for discrete and continuous sources. Classical Hermite expansions are avoided entirely, making use only of the plane …
  24. Laser ablation and fluid flows reveal the mechanism behind spindle and centrosome positioning

    Publication
    Few techniques are available for studying the nature of forces that drive subcellular dynamics. Here we develop two complementary ones. The first is femtosecond stereotactic laser ablation, which …
  25. Implicit Adaptive Mesh Refinement for Dispersive Tsunami Propagation

    Publication
    We present an algorithm to solve the dispersive depth-averaged Serre–Green–Naghdi equations using patch-based adaptive mesh refinement. These equations require adding additional higher derivative terms …
  26. A high-order fast direct solver for surface PDEs

    Publication
    We introduce a fast direct solver for variable-coefficient elliptic PDEs on surfaces based on the hierarchical Poincaré–Steklov method. The method takes as input an unstructured, high …
  27. Genetic variants in DDX53 contribute to autism spectrum disorder associated with the Xp22.11 locus

    Publication
  28. Integrating causal discovery and clinically-relevant insights to explore directional relationships between autistic features, sex at birth, and cognitive abilities.

    Publication
  29. Influence of surface viscosities on the electrodeformation of a prolate viscous drop

    Publication
    Contaminants and other agents are often present at the interface between two fluids, giving rise to rheological properties such as surface shear and dilatational viscosities. The dynamics of …
  30. Keypoint-MoSeq: parsing behavior by linking point tracking to pose dynamics.

    Publication
  31. Early childhood aggression in autistic and non-autistic preschoolers: Prevalence, topography, and relationship to emotional reactivity.

    Publication
  32. ANKS1B encoded AIDA-1 regulates social behaviors by controlling oligodendrocyte function.

    Publication
  33. Prebifurcation enhancement of imbibition-drainage hysteresis cycles

    Publication
    The efficient transport of fluids through disordered media requires a thorough understanding of how the driving rate affects two-phase interface propagation. Despite our understanding of front dynamics …
  34. Effectiveness of multimodal participant recruitment in SPARK, a large, online longitudinal research study of autism.

    Publication
  35. Interpretable neural architecture search and transfer learning for understanding CRISPR–Cas9 off-target enzymatic reactions

    Publication
    Finely-tuned enzymatic pathways control cellular processes, and their dysregulation can lead to disease. Creating predictive and interpretable models for these pathways is challenging because of the complexity …
  36. Analysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injury

    Publication
    Acute kidney injury (AKI) is a major risk factor for long-term adverse outcomes, including chronic kidney disease. In mouse models of AKI, maladaptive repair of the injured …
  37. Explainable Equivariant Neural Networks for Particle Physics: PELICAN

    Publication
    PELICAN is a novel permutation equivariant and Lorentz invariant or covariant aggregator network designed to overcome common limitations found in architectures applied to particle physics problems. Compared to …
  38. Soft matter roadmap

    Publication
    Soft materials are usually defined as materials made of mesoscopic entities, often self-organised, sensitive to thermal fluctuations and to weak perturbations. Archetypal examples are colloids, polymers, amphiphiles …
  39. Provable convergence guarantees for black-box variational inference

    Publication
    Black-box variational inference is widely used in situations where there is no proof that its stochastic optimization succeeds. We suggest this is due to a theoretical gap …
  40. Building a "trap model" of glassy dynamics from a local structural predictor of rearrangements

    Publication
    Here we introduce a variation of the trap model of supercooled liquids based on softness, a particle-based variable identified by machine learning that quantifies the local structural …
  41. Confirmations, correlatons and instabilities of a flexible fiber in an active fluid

    Publication
    Fluid-structure interactions between active and passive components are important for many biological systems to function. A particular example is chromatin in the cell nucleus, where ATP-powered …
  42. Uniqueness and characteristic flow for a non strictly convex singular variational problem

    Publication
    This work addresses the question of uniqueness of the minimizers of a convex but not strictly convex integral functional with linear growth in a two-dimensional setting. The …
  43. Open dataset of theory of mind reasoning in early to middle childhood.

    Publication
  44. Sharp error estimates for target measure diffusion maps with applications to the committor problem

    Publication
    We obtain asymptotically sharp error estimates for the consistency error of the Target Measure Diffusion map (TMDmap) (Banisch et al. 2020), a variant of diffusion maps featuring importance …
  45. Wearable biosensing to predict imminent aggressive behavior in psychiatric inpatient youths with autism.

    Publication
  46. Self-report measurement of well-being in autistic adults: Psychometric properties of the PERMA Profiler

    Publication
  47. Multimodal pathways to joint attention in infants with a familial history of autism.

    Publication
  48. Tunable Tesla-scale magnetic attosecond pulses through ring-current gating

    Publication
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