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Bringing people and ideas together to fund, conduct, and share transformative science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Small molecules, genes and antisense oligonucleotides: Industry perspectives on treatment development for ASD

    Lecture
    Federico Bolognani, Stuart Cobb, and Yael Weiss joined a panel to discuss new industry developments on the use of small molecules, gene therapy and antisense oligonucleotides as treatment …
  2. Simons Collaboration on Algorithms and Geometry Annual Meeting 2021

    Conference
    … cryptography. I will describe how investigating these algorithmic problems led us to discover new geometric properties of lattices. Public Lecture: Friday, May 14th 4:45 – 5:00 …
  3. New research results from the Australian Autism Biobank study

    Lecture
    Jake Gratten and Naomi Wray presented findings from the Australian Autism Biobank study, an initiative to establish an Australian resource of biospecimens, phenotypes and genomic data for autism …
  4. New Research Results From the Australian Autism Biobank Study

    Lecture
    Autism spectrum disorder (ASD) is a complex neurodevelopmental condition whose biological basis is yet to be elucidated. The Australian Autism Biobank (AAB) is an initiative of the Cooperative …
  5. Mathematics of Deep Learning Seminar: Ohad Shamir

    Seminar
    Title: Elephant in the Room: Non-Smooth Non-Convex Optimization Abstract: It is well-known that finding global minima of non-convex optimization problems is computationally hard in …
  6. Biophysical Modeling Group Meeting

    Meeting
    Presenter: Michael O’Brien, Associate Research Analyst Topic: “Computing the Bispectrum across Dimensions and Disciplines”
  7. Systems Biology Group Meeting

    Meeting
    Presenter: Jamie Morton, Ph.D., Associate Research Scientist, Systems Biology Group, CCB Title: Towards an autism microbiome consortium study Abstract: In light of the major advances in discovering …
  8. CCA Colloquium: Mary Putman

    Colloquium
    Title: The Local Gaseous Universe Abstract: The gas in galaxies dictates the fate of their star formation and their total baryon census. In this talk, I will discuss …
  9. Drosophila Journal Club

    Meeting
    Speaker: Jaspreet Singh Topic: Review of models of cytokinesis
  10. Bayes Reading Group: Chirag Modi

    Meeting
    Topic: Green and Mira. Delayed Rejection in Reversible Jump Metropolis-Hastings. Discussion Lead: Chirag Modi, CCA/CCM Paper: https://academic.oup.com/biomet/article/88/4/1035/2722143 …
  11. Time to Take the ‘Big Bang’ out of the Big Bang Theory?

    Lecture
    A wide range of empirical evidence supports the notion that the universe has been expanding and cooling for the last 14 billion years. However, the idea that it …
  12. Neuronal Ensembles

    Related
    The 11th NTC symposium of the NeuroTechnology Center at Columbia University: Neuronal Ensembles. The symposium will feature talks from leading investigators in the fields of developmental neuroscience, sensory …
  13. CCB Brown Bag Seminar

    Lecture
    1st presenter: Xi Chen, PhD, Research Scientist, Genomics Topic: High-resolution chromatin accessibility and gene expression data analysis for MRSA/MSSA Abstract: As a pilot study in a …
  14. Mathematics of Deep Learning Seminar: Julien Mairal

    Seminar
    … less parameters. The second notable fact is the ability to leverage the model interpretability to improve the efficiency of our models for blind denoising. In these two …
  15. Lectures on Diagrammatic Monte Carlo: Extension of CDet: RDet, RPADet, etc. (Riccardo Rossi)

    Lecture
    All lectures in this series will be held 10-11:15am US EDT and are open to all interested scientists. For further information please contact Dr. Igor Tupitsyn …
  16. Biophysical Modeling Group Meeting

    Meeting
    Presenter: Laurel Ohm, NYU Topic: Pattern formation in active suspensions
  17. Systems Biology Group Meeting

    Meeting
    Presenter: Daniel Berenberg Topic: Language modeling for DNA sequences Abstract: Next-generation sequencing efforts have resulted in massive deposits of reliable whole-genome data, namely coding and non …
  18. 2021 CCA Colloquium Schedule

    Colloquium
    Spring 2021 Date Name Title January 29, 2021 Mike Blanton TBD February 5, 2021 Nick Battaglia TBD February 12, 2021 Andrei Beloborodov TBD February 26, 2021 Lam Hui …
  19. CCQ Current and Past Quantum Cafe Schedules

    Colloquium
  20. Mathematics of Deep Learning Seminar Schedule

    Seminar
  21. CCQ Current and Past Workshop Schedules

    Workshop
  22. Biophysics and Development Seminar Series

    Seminar
  23. Changing the Story: How Two Physicians Are Using Technology and Media to Redefine Public Health

    In Conversation
    The necessity for clear science communication extends far beyond the laboratory. It impacts all of us daily, especially when it comes to our health. Join us for a …
  24. Bayes Reading Group: Bob Carpenter

    Meeting
    Topic: Pourzanjani and Petzold. Implicit HMC for sampling multiscale distributions. Discussion Lead: Bob Carpenter, CCM Paper: https://arxiv.org/abs/1911.05754 Please email Sara Mejias Gonzalez at …
  25. ‘X’ Marks the Spot in Female Longevity and Cognitive Aging

    Lecture
    … Mechanisms of Aging, the Grass Award in Neuroscience, and the Neuroendocrine Research Award. She serves in the leadership of JAMA Neurology and is on the board of …
  26. Quantum Cafe Webinar: Karin Rabe

    Colloquium
    Title: Teaching an old dog new tricks: switchable polar materials from first principles Abstract: First-principles methods have proved over recent years to be an increasingly powerful tool …
  27. Mathematics of Deep Learning Seminar: Rachel Ward

    Seminar
    Title: Generalization bounds for sparse random feature expansions Abstract: Random feature methods have been successful in various machine learning tasks, are easy to compute, and come with theoretical …
  28. SCGB Global Postdoc/Student Meeting

    SCGB
    The Simons Collaboration on the Global Brain hosts a Global group meeting to bring together postdocs and PhD students interested in neural coding and dynamics to discuss ideas …
  29. Systems Biology Group Meeting

    Meeting
    Presenter: Meet Barot, New York University Title: Unsupervised Classification of Proteins Abstract: With the large amount of sequence information constantly being generated, it has become an important problem …
  30. CCA Colloquium: Rachel Bean

    Colloquium
    Title: ”Testing gravity with large scale structure” Abstract: Upcoming cosmological surveys, including DESI, Euclid, Rubin LSST and Roman and Simons Observatory and CMB-S4 will provide a wealth …
  31. Simons Collaboration on Algorithms and Geometry Monthly Meeting, April 2021

    Conference
    1:00-3:20 PM Agenda 1:00-1:25 Yufei Zhao, Background and motivation, overview of results, open problems 1:25-2:15 Ashwin Sah, Upper bounds …
  32. CCQ Moiré Group Meeting - Michael Zaletel

    Meeting
    April 22, 2021 Mike Zaletel – Skyrmion pairing: DMRG evidence for a topological route to superconductivity
  33. AI4Science: A Revolution in the Making

    Lecture
    … interdisciplinary applications. Her research focus is on unsupervised AI, optimization, and tensor methods.
  34. CCB Brown Bag Seminar

    Seminar
    1st Speaker: Tatyana Gavrilchenko, Ph.D., Flatiron Research Fellow, Developmental Dynamics Topic: Fluctuating asymmetries in the wing venation of odonates The intricate wing structure of dragonflies has fascinated …
  35. Quantum Cafe Webinar: Simon Trebst

    Colloquium
    Title: Quantum Computing “al dente” Abstract: From the perspective of many body physics, the transmon qubit architectures currently developed for quantum computing are systems of coupled nonlinear quantum …
  36. Mathematics of Deep Learning Seminar: Rong Ge

    Seminar
    Title: A Local Convergence Theory for Mildly Over-Parameterized Two-Layer Neural Network Abstract: While over-parameterization is widely believed to be crucial for the success of optimization …
  37. Lectures on Diagrammatic Monte Carlo: Introduction to Diagrammatic Monte Carlo and CDet (Fedor Simkovic)

    Lecture
    All lectures in this series will be held 10-11:15am US EDT and are open to all interested scientists. For further information please contact Dr. Igor Tupitsyn …
  38. Neural Control of Movement Annual Meeting

    Related
    From its outset, the goal of NCM has been to offer investigators in the field of motor control an opportunity to present their work and to discuss its …
  39. Biophysics & Development Seminar: Pierre Sens,Ph.D., Research Director - CNRS, Team leader - Institut Curie

    Meeting
    Topic: Modelling membrane-bound cellular organelles with non-equilibrium dynamics. Abstract: Membrane-bound cellular organelles perform many essential functions, among which the sorting and biochemical maturation of cellular …
  40. Biophysical Modeling Group Meeting

    Meeting
    Presenter: Adam Lamson, Ph.D., Research Fellow, BPM Group Topic: Mixing biophysics and genomics: the long and winding path of DNA, proteins, and data.
  41. Systems Biology Group Meeting

    Meeting
    Presenter: Michelle Badri, Ph.D. Candidate, New York University Title: Instrumental variables design for high-dimensional microbiome data Abstract: Instrumental variables estimation is an approach to causal inference …
  42. G-Node Advanced Neural Data Analysis Course 2021

    Related
    Techniques to record neuronal data from populations of neurons are rapidly improving. Simultaneous recordings from hundreds of channels are possible while animals perform complex behavioral tasks. The analysis …
  43. CCA Colloquium: Jeremy Tinker

    Colloquium
    Title: How much control does dark matter have over galaxy formation? Abstract: We know that the formation of halos and galaxies are correlated— more massive galaxies grow in …
  44. Computational Bayesian Statistics Journal Club

    Meeting
    Discussion Lead: Mariano Gabbitto, Flatiron; CCB Topic: Visualization in Bayesian Workflow Paper: https://arxiv.org/abs/1709.01449 Please email Sara Mejias Gonzalez at [email protected] for …
  45. Can Aging be Reversed in the Brain?

    Lecture
    … impairments. Villeda’s research is best known for using innovative heterochronic parabiosis and blood plasma administration approaches to investigate the influence that exposure to young blood has …
  46. CCB Colloquium: Ramin Golestanian

    Colloquium
    Presenter: Ramin Golestanian, Ph.D. Max Planck Institute for Dynamics and Self-Organization in Göttingen and Oxford University Title: A classical analogue of Bose-Einstein condensation in active …
  47. Biophysical Modeling Group Meeting

    Meeting
    Presenter: Jaspreet Singh, Ph.D., Flatiron Research Fellow, Developmental Dynamics Topic: Biophysics of Arrested Cytokinesis
  48. Systems Biology Group Meeting

    Meeting
    Presenter: Sonya Hanson, Ph.D., Structural & Molecular Biophysics Collaboration, Center for Computational Biology Title: Elucidating mechanisms of biological temperature sensing Abstract: Despite the existence of engineered thermometers since …
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