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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Mapping light-dressed Floquet bands by highly nonlinear optical excitations and valley polarization

    Publication
  2. Metal-insulator transition and quantum magnetism in the SU(3) Fermi-Hubbard model

    Publication
  3. Metal-insulator transition and quantum magnetism in the SU(3) Fermi-Hubbard model

    Publication
  4. Metal-insulator transition and quantum magnetism in the SU(3) Fermi-Hubbard model

    Publication
  5. Metal-insulator transition and quantum magnetism in the SU(3) Fermi-Hubbard model

    Publication
  6. Metal-insulator transition and quantum magnetism in the SU(3) Fermi-Hubbard model

    Publication
  7. Metal-insulator transition and quantum magnetism in the SU(3) Fermi-Hubbard model

    Publication
  8. Metal-insulator transition and quantum magnetism in the SU(3) Fermi-Hubbard model

    Publication
  9. Metal-insulator transition and quantum magnetism in the SU(3) Fermi-Hubbard model

    Publication
  10. Fate of Quasiparticles at High Temperature in the Correlated Metal Sr

    Publication
  11. Metal-insulator transition and quantum magnetism in the SU(3) Fermi-Hubbard model

    Publication
  12. Comparing neural models using their perceptual discriminability predictions

    Publication
    Internal representations are not uniquely identifiable from perceptual measurements: different representations can generate identical perceptual predictions, and similar representations may predict dissimilar percepts. Here, we generalize a previous …
  13. Efficient coding of natural images using maximum manifold capacity representations

    Publication
    The efficient coding hypothesis posits that sensory systems are adapted to the statistics of their inputs, maximizing mutual information between environmental signals and their representations, subject to biological …
  14. Adaptive whitening with fast gain modulation and slow synaptic plasticity

    Publication
    Neurons in early sensory areas rapidly adapt to changing sensory statistics, both by normalizing the variance of their individual responses and by reducing correlations between their responses. Together …
  15. A polar prediction model for learning to represent visual transformations

    Publication
    All organisms make temporal predictions, and their evolutionary fitness level depends on the accuracy of these predictions. In the context of visual perception, the motions of both the …
  16. Characterizing subdomains of insistence on sameness in autistic youth.

    Publication
  17. Targeted V1 comodulation supports task-adaptive sensory decisions

    Publication
    Sensory-guided behavior requires reliable encoding of stimulus information in neural populations, and flexible, task-specific readout. The former has been studied extensively, but the latter remains poorly …
  18. Endogenous noise of neocortical neurons correlates with atypical sensory response variability in the Fmr1-/y mouse model of autism

    Publication
  19. Copy-number variants and polygenic risk for intelligence confer risk for autism spectrum disorder irrespective of their effects on cognitive ability.

    Publication
  20. Improving Convergence and Generalization Using Parameter Symmetries

    Publication
    In overparametrized models, different parameter values may result in the same loss. Parameter space symmetries are loss-invariant transformations that change the model parameters. Teleportation applies such transformations …
  21. Single-cell long-read sequencing in human cerebral organoids uncovers cell-type-specific and autism-associated exons.

    Publication
  22. A dynamical model of growth and maturation in Drosophila

    Publication
    The decision to stop growing and mature into an adult is a critical point in development that determines adult body size, impacting multiple aspects of an adult’s …
  23. The phenotypic variability of 16p11.2 distal BP2-BP3 deletion in a transgenerational family and in neurodevelopmentally ascertained samples.

    Publication
  24. Morphogens enable interacting supracellular phases that generate organ architecture

    Publication
    During vertebrate organ morphogenesis, large collectives of cells robustly self-organize to form architectural units (bones, villi, follicles) whose form persists into adulthood. Over the past few decades …
  25. Microscopic Theory, Analysis, and Interpretation of Conductance Histograms in Molecular Junctions

    Publication
    Molecular electronics break-junction experiments are widely used to investigate fundamental physics and chemistry at the nanoscale. Reproducibility in these experiments relies on measuring conductance on thousands of …
  26. Genetically predicted causal associations between periodontitis and psychiatric disorders.

    Publication
  27. Genomic data resources of the Brain Somatic Mosaicism Network for neuropsychiatric diseases.

    Publication
  28. Bacterial diffusion in disordered media, by forgetting the media

    Publication
    We study bacterial diffusion in disordered porous media. Interactions with obstacles, at unknown locations, make this problem challenging. We approach it by abstracting the environment to cell states …
  29. Sculpting the Sphinx

    Publication
    This paper is associated with a poster winner of a 2022 American Physical Society's Division of Fluid Dynamics (DFD) Milton van Dyke Award for work presented at …
  30. Hyperthermia elevates brain temperature and improves behavioural signs in animal models of autism spectrum disorder.

    Publication
  31. Dispersion of run-and-tumble microswimmers through disordered media

    Publication
    Understanding the transport properties of microorganisms and self-propelled particles in porous media has important implications for human health as well as microbial ecology. In free space, most …
  32. The power of weak, transient interactions across biology: A paradigm of emergent behavior

    Publication
    A growing list of diverse biological systems and their equally diverse functionalities provides realizations of a paradigm of emergent behavior. In each of these biological systems, pervasive ensembles …
  33. Genetic ablation of GIGYF1, associated with autism, causes behavioral and neurodevelopmental defects in zebrafish and mice.

    Publication
  34. A chemomechanical model of sperm locomotion reveals two modes of swimming

    Publication
    The propulsion of mammalian spermatozoa relies on the spontaneous periodic oscillation of their flagella. These oscillations are driven internally by the coordinated action of ATP-powered dynein motors …
  35. Bayesian spatial modelling of localised SARS-CoV-2 transmission through mobility networks across England

    Publication
    In the early phases of growth, resurgent epidemic waves of SARS-CoV-2 incidence have been characterised by localised outbreaks. Therefore, understanding the geographic dispersion of emerging variants …
  36. A model of replicating coupled oscillators generates naturally occurring cell networks

    Publication
    When a founder cell and its progeny divide with incomplete cytokinesis, a network forms in which each intercellular bridge corresponds to a past mitotic event. Such networks are …
  37. Cre-dependent massively parallel reporter assay allows for cell-type specific assessment of the functional effects of genetic variants in vivo.

    Publication
  38. Spatiotemporal Clustering with Neyman-Scott Processes via Connections to Bayesian Nonparametric Mixture Models

    Publication
    Neyman-Scott processes (NSPs) are point process models that generate clusters of points in time or space. They are natural models for a wide range of phenomena, ranging …
  39. Equilibrium quantum impurity problems via matrix product state encoding of the retarded action

    Publication
    In the 0 + 1 -dimensional imaginary-time path integral formulation of quantum impurity problems, the retarded action encodes the hybridization of the impurity with the bath. In this …
  40. IIM2FieldII: A Framework for Validating Ultrasound Measurements of Volumetric Flow and WSS in Complex Carotid Plaque Geometries

    Publication
    High wall shear stress (WSS) is associated with risk of atherosclerotic plaque rupture, but there are numerous gaps in validating ultrasound-derived measurements of the parameter. Two major …
  41. Birth of a Transformer: A Memory Viewpoint

    Publication
    Large language models based on transformers have achieved great empirical successes. However, as they are deployed more widely, there is a growing need to better understand their internal …
  42. Protein-Engineered Fibers For Drug Encapsulation Traceable via 19F Magnetic Resonance

    Publication
    Theranostic materials research is experiencing rapid growth driven by the interest in integrating both therapeutic and diagnostic modalities. These materials offer the unique capability to not only provide …
  43. On Learning Gaussian Multi-index Models with Gradient Flow

    Publication
    We study gradient flow on the multi-index regression problem for high-dimensional Gaussian data. Multi-index functions consist of a composition of an unknown low-rank linear …
  44. Extracting thermodynamic properties from van ’t Hoff plots with emphasis on temperature-sensing ion channels

    Publication
    Transient receptor potential (TRP) ion channels are among the most well-studied classes of temperature-sensing molecules. Yet, the molecular mechanism and thermodynamic basis for the temperature sensitivity …
  45. Peripheral temperature dysregulation associated with functionally altered NaV1.8 channels.

    Publication
  46. Remote vs. In-person Schooling during the COVID-19 Pandemic and Internalizing Symptoms among Children on the Autism Spectrum.

    Publication
  47. Phonon-Enhanced Nonlinearities in Hexagonal Boron Nitride

    Publication
  48. Weakened Topological Protection of the Quantum Hall Effect in a Cavity

    Publication
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