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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Cavity Click Chemistry: Cavity-Catalyzed Azide--Alkyne Cycloaddition

    Publication
  2. Introduction: Polaritonic Chemistry

    Publication
  3. Exact solution to the fully connected XY model with Gaussian random fields by the replica method

    Publication
  4. Algorithm for branching and population control in correlated sampling

    Publication
  5. Theory of shot noise in strange metals

    Publication
  6. Mott insulators with boundary zeros

    Publication
  7. Foveated metamers of the early visual system

    Publication
    Human ability to discriminate and identify visual attributes varies across the visual field, and is generally worse in the periphery than in the fovea. This decline in performance …
  8. Universal scaling of shear thickening transitions

    Publication
    Nearly, all dense suspensions undergo dramatic and abrupt thickening transitions in their flow behavior when sheared at high stresses. Such transitions occur when the dominant interactions between the …
  9. Contrastive power-efficient physical learning in resistor networks

    Publication
    The prospect of substantial reductions in the power consumption of AI is a major motivation for the development of neuromorphic hardware. Less attention has been given to the …
  10. Nonlinear Classification Without a Processor

    Publication
    Computers, as well as most neuromorphic hardware systems, use central processing and top-down algorithmic control to train for machine learning tasks. In contrast, brains are ensembles of …
  11. Phase plane dynamics of ERK phosphorylation

    Publication
    The extracellular signal–regulated kinase (ERK) controls multiple critical processes in the cell and is deregulated in human cancers, congenital abnormalities, immune diseases, and neurodevelopmental syndromes. Catalytic activity …
  12. Examining treatment outcomes across contexts: How do child baseline characteristics impact measurement of treatment response?

    Publication
  13. DeepGAMI: deep biologically guided auxiliary learning for multimodal integration and imputation to improve genotype-phenotype prediction.

    Publication
  14. Deficits in integrative NMDA receptors caused by Grin1 disruption can be rescued in adulthood.

    Publication
  15. Direct stellarator coil design using global optimization: application to a comprehensive exploration of quasi-axisymmetric devices

    Publication
    Many stellarator coil design problems are plagued by multiple minima, where the locally optimal coil sets can sometimes vary substantially in performance. As a result, solving a coil …
  16. Quantum Fourier Transform Has Small Entanglement

    Publication
    The quantum Fourier transform (QFT) is a key component of many important quantum algorithms, most famously being the essential ingredient in Shor’s algorithm for factoring products of …
  17. Discriminative calibration: Check Bayesian computation from simulations and flexible classifier

    Publication
    To check the accuracy of Bayesian computations, it is common to use rank-based simulation-based calibration (SBC). However, SBC has drawbacks: The test statistic is somewhat ad …
  18. Stochastic force inference via density estimation

    Publication
    Inferring dynamical models from low-resolution temporal data continues to be a significant challenge in biophysics, especially within transcriptomics, where separating molecular programs from noise remains an important …
  19. Lack of chromokinesin Klp-19 creates a more rigid midzone and affects force transmission during anaphase in C. elegans

    Publication
    Recent studies have highlighted the significance of the spindle midzone – the region positioned between chromosomes – in ensuring proper chromosome segregation. By combining advanced 3D electron tomography and cutting …
  20. Scaffold Matcher: A CMA-ES based algorithm for identifying hotspot aligned peptidomimetic scaffolds

    Publication
    The design of protein interaction inhibitors is a promising approach to address aberrant protein interactions that cause disease. One strategy in designing inhibitors is to use peptidomimetic scaffolds …
  21. Development shapes the evolutionary diversification of rodent stripe patterns

    Publication
    Vertebrate groups have evolved strikingly diverse color patterns. However, it remains unknown to what extent the diversification of such patterns has been shaped by the proximate, developmental mechanisms …
  22. Modeling epithelial tissue and cell deformation dynamics using a viscoelastic slab sculpted by surface forces

    Publication
    During morphogenesis, epithelial monolayers actively alter their shape to create future body parts of the animal; this makes the epithelium one of the most active and critical structures …
  23. Adaptive weighting of Bayesian physics informed neural networks for multitask and multiscale forward and inverse problems

    Publication
    In this paper, we present a novel methodology for automatic adaptive weighting of Bayesian Physics-Informed Neural Networks (BPINNs), and we demonstrate that this makes it possible to …
  24. Robust hierarchically organized whole-brain patterns of dysconnectivity in schizophrenia spectrum disorders observed after personalized intrinsic network topography.

    Publication
  25. Long COVID-19 syndrome associated with Omicron XBB.1.5 infection: a case report.

    Publication
  26. Age-related changes in neural responses to sensory stimulation in autism: a cross-sectional study.

    Publication
  27. From localized to well mixed: How commuter interactions shape disease spread

    Publication
    Interactions between commuting individuals can lead to large-scale spreading of rumors, ideas, or disease, even though the commuters have no net displacement. The emergent dynamics depend crucially …
  28. Identifying microscopic factors that influence ductility in disordered solids

    Publication
    There are empirical strategies for tuning the degree of strain localization in disordered solids, but they are system-specific and no theoretical framework explains their effectiveness or limitations …
  29. A multifunctional Wnt regulator underlies the evolution of rodent stripe patterns

    Publication
    Animal pigment patterns are excellent models to elucidate mechanisms of biological organization. Although theoretical simulations, such as Turing reaction–diffusion systems, recapitulate many animal patterns, they are insufficient …
  30. Solving the Transmission Problem for Open Wave-Guides, II Outgoing Estimates

    Publication
    The paper continues the analysis, started in [1] (Part I,arXiv:2302.04353), of the model open wave-guide problem defined by 2 semi-infinite, rectangular wave-guides …
  31. Primary complex motor stereotypies are associated with de novo damaging DNA coding mutations that identify KDM5B as a risk gene.

    Publication
  32. Solving the Transmission Problem for Open Wave-Guides, I Fundamental Solutions and Integral Equations

    Publication
    We introduce a layer potential representation for the solution of the transmission problem defined by two dielectric channels, or open wave-guides, meeting along the straight-line interface …
  33. Identifying crossovers and shared genetic material in whole genome sequencing data from families.

    Publication
  34. Epilepsy-associated SCN2A (NAV1.2) variants exhibit diverse and complex functional properties.

    Publication
  35. Controlling the magnetic state of the proximate quantum spin liquid α-RuCl

    Publication
  36. Robustness of Trion State in Gated Monolayer MoSe2 under Pressure

    Publication
  37. Non-Linear Optics at Twist Interfaces in h-BN/SiC Heterostructures

    Publication
  38. Slowly decaying zero mode in a weakly nonintegrable boundary impurity model

    Publication
  39. Attractive Su-Schrieffer-Heeger-Hubbard model on a square lattice away from half-filling

    Publication
  40. A class of dimensionality-free metrics for the convergence of empirical measures

    Publication
    This paper concerns the convergence of empirical measures in high dimensions. We propose a new class of probability metrics and show that under such metrics, the convergence is …
  41. Design principles of Cdr2 node patterns in fission yeast cells

    Publication
    Pattern-forming networks have diverse roles in cell biology. Rod-shaped fission yeast cells use pattern formation to control the localization of mitotic signaling proteins and the cytokinetic …
  42. A Neural Network Warm-Start Approach for the Inverse Acoustic Obstacle Scattering Problem

    Publication
    In this paper, we consider the inverse acoustic obstacle problem for sound-soft star-shaped obstacles in two dimensions wherein the boundary of the obstacle is determined from …
  43. Mutations in genes related to myocyte contraction and ventricular septum development in non-syndromic tetralogy of Fallot.

    Publication
  44. Mutations in genes related to myocyte contraction and ventricular septum development in non-syndromic tetralogy of Fallot.

    Publication
  45. Developing a measure of key adult outcomes in adults with developmental disabilities: Conceptual model and item generation of the REALS (Relationships, Employment, Autonomy, and Life Satisfaction).

    Publication
  46. Atlas of primary cell-type-specific sequence models of gene expression and variant effects

    Publication
    Human biology is rooted in highly specialized cell types programmed by a common genome, 98% of which is outside of genes. Genetic variation in the enormous noncoding space …
  47. Parental tuning of language input to autistic and nonspectrum children.

    Publication
  48. Rare variation in noncoding regions with evolutionary signatures contributes to autism spectrum disorder risk.

    Publication
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