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  1. Single cell analysis of dup15q syndrome reveals developmental and postnatal molecular changes in autism.

    Publication

  2. Benchmarking of local genetic correlation estimation methods using summary statistics from genome-wide association studies

    Publication

  3. Variational Inference with Gaussian Score Matching

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    Variational inference (VI) is a method to approximate the computationally intractable posterior distributions that arise in Bayesian statistics. Typically, VI fits a simple parametric distribution to be close …

  4. Increased rates of chronic physical health conditions across all organ systems in autistic adolescents and adults.

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  5. Phenotype and genetic analysis of data collected within the first year of NeuroDev.

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  6. Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle

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    Insulin resistance (IR) is a complex metabolic disorder that underlies several human diseases, including type 2 diabetes and cardiovascular disease. Despite extensive research, the precise mechanisms underlying IR …

  7. Scaling behaviour and control of nuclear wrinkling

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    The cell nucleus is enveloped by a complex membrane, whose wrinkling has been implicated in disease and cellular aging. The biophysical dynamics and spectral evolution of nuclear wrinkling …

  8. Community providers' reported use of treatment practices in the United States.

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  9. Accelerated longitudinal weight gain among infants with in utero COVID-19 exposure.

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  10. Classification of missense variants in the N-methyl-d-aspartate receptor GRIN gene family as gain- or loss-of-function.

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  11. FMM-accelerated solvers for the Laplace-Beltrami problem on complex surfaces in three dimensions

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    The Laplace–Beltrami problem on closed surfaces embedded in three dimensions arises in many areas of physics, including molecular dynamics (surface diffusion), electromagnetics (harmonic vector fields), and fluid …

  12. Hierarchical bubble size distributions in coarsening wet liquid foams

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    Coarsening of two-phase systems is crucial for the stability of dense particle packingssuch as alloys, foams, emulsions, or supersaturated solutions. Mean field theoriespredict an asymptotic scaling state …

  13. Single-cell brain organoid screening identifies developmental defects in autism.

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  14. SnapShot: Reporting practices for publishing results with human PSCs and tissue stem cells.

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  15. Clustering of cortical dynein regulates the mechanics of spindle orientation in human mitotic cells

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    The forces which orient the spindle in human cells remain poorly understood due to a lack of direct mechanical measurements in mammalian systems. We use magnetic tweezers to …

  16. The relationship between augmentative and alternative communication use by pediatric psychiatric inpatients with autism spectrum disorder and interfering behaviors.

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  17. A Gentle Introduction to Gradient-Based Optimization and Variational Inequalities for Machine Learning

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    The rapid progress in machine learning in recent years has been based on a highly productive connection to gradient-based optimization. Further progress hinges in part on a …

  18. Liquid Filled Elastomers: From Linearization to Elastic Enhancement

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    Surface tension at cavity walls can play havoc with the mechanical properties of perforated soft solids when the cavities are filled with a fluid. This study is an …

  19. Subcortical brain alterations in carriers of genomic copy number variants.

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  20. Understanding polaritonic chemistry from ab initio quantum electrodynamics

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  21. High-harmonic spectroscopy of low-energy electron-scattering dynamics in liquids

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  22. High-harmonic generation in liquids with few-cycle pulses: effect of laser-pulse duration on the cut-off energy

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  23. Interfacing Branching Random Walks with Metropolis Sampling: Constraint Release in Auxiliary-Field Quantum Monte Carlo

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  24. Cavity-renormalized quantum criticality in a honeycomb bilayer antiferromagnet

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  25. Ideal Chern bands are Landau levels in curved space

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  26. Combining Electron-Phonon and Dynamical Mean-Field Theory Calculations of Correlated Materials: Transport in the Correlated Metal Sr

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  27. Reinforcement learning with function approximation: From linear to nonlinear

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    Function approximation has been an indispensable component in modern reinforcement learning algorithms designed to tackle problems with large state spaces in high dimensions. This paper reviews recent results …

  28. Learning Vector Quantized Shape Code for Amodal Blastomere Instance Segmentation

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    Blastomere instance segmentation is important for analyzing embryos’ abnormality. To measure the accurate shapes and sizes of blastomeres, their amodal segmentation is necessary. Amodal instance segmentation aims to …

  29. Multi-Task Curriculum Learning for Partially Labeled Data

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    Incomplete labels are common in multi-task learning for biomedical applications due to several practical difficulties, e.g., expensive annotation efforts by experts, limit of data collection, different …

  30. Three generation families: Analysis of de novo variants in autism.

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  31. Discovery of eQTL alleles associated with autism spectrum disorder: A case-control study.

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  32. The autism impact measure (AIM): Meaningful change thresholds and core symptom changes over one year from an online survey in the U.S.

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  33. An equivariant neural operator for developing nonlocal tensorial constitutive models

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    Developing robust constitutive models is a fundamental and longstanding problem for accelerating the simulation of complicated physics. Machine learning provides promising tools to construct constitutive models based on …

  34. Neural network adaptive coding efficiency and stochastic representational geometry

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    This dissertation investigates two fundamental aspects of neural population coding: adaptive coding efficiency and stochastic representational geometry. We introduce a theory for adaptive statistical whitening revolving around a …

  35. Examining the latent structure and correlates of sensory reactivity in autism: a multi-site integrative data analysis by the autism sensory research consortium.

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  36. A unified model for the co-evolution of galaxies and their circumgalactic medium: the relative roles of turbulence and atomic cooling physics

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    The circumgalactic medium (CGM) plays a pivotal role in regulating gas flows around galaxies and thus shapes their evolution. However, the details of how galaxies and their CGM …

  37. Structure-function analysis suggests that the photoreceptor LITE-1 is a light-activated ion channel

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    Sensation of light is essential for all organisms. The eye-less nematode Caenorhabditis elegans detects UV and blue light to evoke escape behavior. The photosensor LITE-1 absorbs …

  38. Behavioral parent training engagement among young children with autism spectrum disorder.

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  39. A Hierarchical Bayesian Framework for Inferring the Stellar Obliquity Distribution

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    Stellar obliquity, the angle between a planet's orbital axis and its host star's spin axis, traces the formation and evolution of a planetary system. In transiting …

  40. Discontinuous instabilities in disordered solids

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    Under a sufficiently large load, a solid material will flow via rearrangements, where particles change neighbors. Such plasticity is most easily described in the athermal, quasistatic limit of …

  41. Protocol for the development of joint attention-based subclassification of autism spectrum disorder and validation using multi-modal data.

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  42. Automatic, high-order, and adaptive algorithms for Brillouin zone integration

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    We present efficient methods for Brillouin zone integration with a non-zero but possibly very small broadening factor η, focusing on cases in which downfolded Hamiltonians can be …

  43. Generation and motion of interfaces in a mass-conserving reaction-diffusion system

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    Reaction-diffusion models with nonlocal constraints naturally arise as limiting cases of coupled bulk-surface models of intracellular signalling. In this paper, a minimal, mass-conserving model of …

  44. Evolutionary history of MEK1 illuminates the nature of deleterious mutations

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    Mutations in signal transduction pathways lead to various diseases including cancers. MEK1 kinase, encoded by the human MAP2K1 gene, is one of the central components of the MAPK …

  45. Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis.

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  46. Genetic control of mRNA splicing as a potential mechanism for incomplete penetrance of rare coding variants.

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  47. Genetic control of mRNA splicing as a potential mechanism for incomplete penetrance of rare coding variants.

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  48. DeePMD-kit v2: A software package for deep potential models

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    DeePMD-kit is a powerful open-source software package that facilitates molecular dynamics simulations using machine learning potentials known as Deep Potential (DP) models. This package, which was …