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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Multi-level analysis of the gut–brain axis shows autism spectrum disorder-associated molecular and microbial profiles

    Publication
    Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by heterogeneous cognitive, behavioral and communication impairments. Disruption of the gut–brain axis (GBA) has been implicated in ASD …
  2. General adjoint-differentiated Laplace approximation

    Publication
    The hierarchical prior used in Latent Gaussian models (LGMs) induces a posterior geometry prone to frustrate inference algorithms. Marginalizing out the latent Gaussian variable using an integrated Laplace …
  3. Elevated levels of FMRP-target MAP1B impair human and mouse neuronal development and mouse social behaviors via autophagy pathway.

    Publication
  4. Structural neuroplasticity after sleep loss modifies behavior and requires neurexin and neuroligin.

    Publication
  5. Backward Population Synthesis: Mapping the Evolutionary History of Gravitational-wave Progenitors

    Publication
    One promising way to extract information about stellar astrophysics from a gravitational-wave catalog is to compare the catalog to the outputs of stellar population synthesis modeling with …
  6. P-175 Human cumulus cell telomere length and its association with assisted reproduction outcome

    Publication
    Study question: Is there any relationship between the relative telomere length (RTL) within cumulus cells (CCs) and the outcome of assisted reproductive treatment using the corresponding oocyte? Summary …
  7. Environmental adversity moderates polygenic score effects on childhood behavioral problems in the United States.

    Publication
  8. Code Comparison in Galaxy-scale Simulations with Resolved Supernova Feedback: Lagrangian versus Eulerian Methods

    Publication
    We present a suite of high-resolution simulations of an isolated dwarf galaxy using four different hydrodynamical codes: {sc Gizmo}, {sc Arepo}, {sc Gadget}, and {sc Ramses}. All …
  9. Improving Gradient Computation for Differentiable Physics Simulation with Contacts

    Publication
    Differentiable simulation enables gradients to be back-propagated through physics simulations. In this way, one can learn the dynamics and properties of a physics system by gradient-based …
  10. riccati: an adaptive, spectral solver for oscillatory ODEs

    Publication
  11. Low-rank Green's function representations applied to dynamical mean-field theory

    Publication
    Several recent works have introduced highly compact representations of single-particle Green's functions in the imaginary time and Matsubara frequency domains, as well as efficient interpolation grids …
  12. An unusual pulse shape change event in PSR J1713+0747 observed with the Green Bank Telescope and CHIME

    Publication
    The millisecond pulsar J1713+0747 underwent a sudden and significant pulse shape change between April 16 and 17, 2021 (MJDs 59320 and 59321). Subsequently, the pulse shape gradually …
  13. Ensemble Reweighting Using Cryo-EM Particle Images

    Publication
    Cryo-electron microscopy (cryo-EM) has recently become a leading method for obtaining high-resolution structures of biological macromolecules. However, cryo-EM is limited to biomolecular samples with …
  14. Ensemble reweighting using Cryo-EM particles

    Publication
    Cryo-electron microscopy (cryo-EM) has recently become a leading method for obtaining high-resolution structures of biological macromolecules. However, cryo-EM is limited to biomolecular samples with …
  15. Dual mechanism of kinetochore microtubule detachment

    Publication
    During eukaryotic cell division, microtubules connect to chromosomes by attaching to the kinetochore via the NDC80 complex (NDC80c). The regulation of kinetochore microtubule (KMT) detachment is crucial for …
  16. Glial dysregulation in the human brain in fragile X-associated tremor/ataxia syndrome.

    Publication
  17. Immersive and maladaptive daydreaming and divergent thinking in autism spectrum disorders.

    Publication
  18. Agreement of parent-reported cognitive level with standardized measures among children with autism spectrum disorder.

    Publication
  19. Agreement of parent-reported cognitive level with standardized measures among children with autism spectrum disorder.

    Publication
  20. A PROMIS®ing new measure for quantifying emotion dysregulation in toddlers and preschoolers: Development of the Emotion Dysregulation Inventory-Young Child.

    Publication
  21. Chirality selective magnon-phonon hybridization and magnon-induced chiral phonons in a layered zigzag antiferromagnet

    Publication
  22. Protected spin-orbit induced absorption divergence in distorted Landau levels

    Publication
  23. Toward an accurate equation of state and B1-B2 phase boundary for magnesium oxide up to terapascal pressures and electron-volt temperatures

    Publication
  24. Tensor train continuous time solver for quantum impurity models

    Publication
  25. Non-perturbative many-body treatment of molecular magnets

    Publication
  26. Intrinsically multilayer moiré heterostructures

    Publication
  27. Low rank Green's function representations applied to dynamical mean-field theory

    Publication
  28. Electron cooling in graphene enhanced by plasmon-hydron resonance

    Publication
  29. Algebraically rigorous quaternion framework for the neural network pose estimation problem

    Publication
    The 3D pose estimation problem – aligning pairs of noisy 3D point clouds – is a problem with a wide variety of real- world applications. Here we focus on the …
  30. Reliability of the Motor Optimality Score-Revised: A study of infants at elevated likelihood for adverse neurological outcomes.

    Publication
  31. Data-driven dissection of the fever effect in autism spectrum disorder.

    Publication
  32. Conditionally Strongly Log-Concave Generative Models

    Publication
    There is a growing gap between the impressive results of deep image generative models and classical algorithms that offer theoretical guarantees. The former suffer from mode collapse or …
  33. Bose-Einstein condensation in honeycomb dimer magnets and Yb2Si2O7

    Publication
    An asymmetric Bose-Einstein condensation (BEC) dome was observed in a recent experiment on the quantum dimer magnet Yb2Si2O7 [G. Hester et al., Phys. Rev. Lett. 123, 027201 …
  34. Rubella virus tropism and single cell responses in human primary tissue and microglia-containing organoids.

    Publication
  35. Repetitive and restricted behaviors and interests in autism spectrum disorder: relation to individual characteristics and mental health problems.

    Publication
  36. Challenges in screening for de novo noncoding variants contributing to genetically complex phenotypes.

    Publication
  37. CERT1 mutations perturb human development by disrupting sphingolipid homeostasis.

    Publication
  38. Examining indicators of psychosocial risk and resilience in parents of autistic children.

    Publication
  39. Effects of tunable hydrophobicity on the collective hydrodynamics of Janus particles under flows

    Publication
    Active colloidal systems with nonequilibrium self-organization constitute a long-standing, challenging area in material sciences and biology. To understand how hydrodynamic flow may be used to actively …
  40. Active galactic nucleus jet feedback in hydrostatic haloes

    Publication
    Feedback driven by jets from active galactic nuclei is believed to be responsible for reducing cooling flows in cool-core galaxy clusters. We use simulations to model feedback …
  41. Cultured Renal Proximal Tubular Epithelial Cells Resemble a Stressed/Damaged Kidney While Supporting BK Virus Infection

    Publication
    BK virus (BKV; human polyomavirus 1) infections are asymptomatic in most individuals, and the virus persists throughout life without harm. However, BKV is a threat to transplant patients …
  42. A methylation clock model of mild SARS-CoV-2 infection provides insight into immune dysregulation

    Publication
    DNA methylation comprises a cumulative record of lifetime exposures superimposed on genetically determined markers. Little is known about methylation dynamics in humans following an acute perturbation, such as …
  43. Sharing parental genomes by siblings concordant or discordant for autism.

    Publication
  44. A Stochastic Proximal Polyak Step Size

    Publication
    Recently, the stochastic Polyak step size (SPS) has emerged as a competitive adaptive step size scheme for stochastic gradient descent. Here we develop ProxSPS, a proximal variant of …
  45. Cross-replicating findings on unique motor impairments of children with ASD using confirmatory factor analysis and a novel SPARK study sample.

    Publication
  46. Clinical, neuroimaging and molecular characteristics of PPP2R5D-related neurodevelopmental disorders: An expanded series with functional characterisation and genotype-phenotype analysis.

    Publication
  47. Floquet-Bloch resonances in near-petahertz electroabsorption spectroscopy of SiO

    Publication
  48. Time-resolved plasmon-assisted generation of optical-vortex pulses

    Publication
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