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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Inelastic Light Scattering in the Vicinity of a Single-Atom Quantum Point Contact in a Plasmonic Picocavity

    Publication
  2. Detection and Modeling of Hole Capture by Single Point Defects under Variable Electric Fields

    Publication
  3. Conductivity of infinite-layer NdNiO

    Publication
  4. Computation of forces and stresses in solids: towards accurate structural optimizations with auxiliary-field quantum Monte Carlo

    Publication
  5. Learning multi-scale local conditional probability models of images

    Publication
    Deep neural networks can learn powerful prior probability models for images, as evidenced by the high-quality generations obtained with recent score-based diffusion methods. But the means …
  6. Dissecting Flux Balances to Measure Energetic Costs in Cell Biology: Techniques and Challenges

    Publication
    Life is a nonequilibrium phenomenon: Metabolism provides a continuous supply of energy that drives nearly all cellular processes. However, very little is known about how much energy different …
  7. Learning multi-scale local conditional probability models of images

    Publication
    Deep neural networks can learn powerful prior probability models for images, as evidenced by the high-quality generations obtained with recent score-based diffusion methods. But the means …
  8. Identifying rare genetic variants in 21 highly multiplex autism families: The role of diagnosis and autistic traits.

    Publication
  9. Dimensional assessment of restricted and repetitive behaviors: Development and preliminary validation of a new measure.

    Publication
  10. Effect of children’s autism spectrum disorder severity on family strain and sleep quality: A cross-sectional online survey in the U.S.

    Publication
  11. Sequence-structure-function relationships in the microbial protein universe

    Publication
    For the past half-century, structural biologists relied on the notion that similar protein sequences give rise to similar structures and functions. While this assumption has driven research …
  12. Synaptic boutons are smaller in chandelier cell cartridges in autism.

    Publication
  13. Complex-to-Real Sketches for Tensor Products with Applications to the Polynomial Kernel

    Publication
    Randomized sketches of a tensor product of pvectors follow a tradeoff between statistical efficiency and computational acceleration. Commonly used approaches avoid computing the high-dimensional tensor product explicitly …
  14. A Cheat Sheet for Bayesian Prediction

    Publication
    This paper reviews the growing field of Bayesian prediction. Bayes point and interval prediction are defined and exemplified and situated in statistical prediction more generally. Then, four general …
  15. Functional brain networks reflect spatial and temporal autocorrelation.

    Publication
  16. A 3D View of Orion. I. Barnard's Loop

    Publication
    Barnard's Loop is a famous arc of Hα emission located in the Orion star-forming region. Here, we provide evidence of a possible formation mechanism for Barnard …
  17. Pyramidal neurons form active, transient, multilayered circuits perturbed by autism-associated mutations at the inception of neocortex.

    Publication
  18. Simulation-based inference of single-molecule force spectroscopy

    Publication
    Single-molecule force spectroscopy (smFS) is a powerful approach to studying molecular self-organization. However, the coupling of the molecule with the ever-present experimental device introduces artifacts …
  19. Simulation-based inference of single-molecule force spectroscopy

    Publication
    Single-molecule force spectroscopy (smFS) is a powerful approach to studying molecular self-organization. However, the coupling of the molecule with the ever-present experimental device introduces artifacts …
  20. Using brain cell-type-specific protein interactomes to interpret genetic data in schizophrenia.

    Publication
  21. Ventral striatal dopamine encodes unique properties of visual stimuli in mice.

    Publication
  22. A fast, accurate and easy to implement Kapur -- Rokhlin quadrature scheme for singular integrals in axisymmetric geometries

    Publication
    Many applications in magnetic confinement fusion require the efficient calculation of surface integrals with singular integrands. The singularity subtraction approaches typically used to handle such singularities are complicated …
  23. Generative Modeling via Hierarchical Tensor Sketching

    Publication
    We propose a hierarchical tensor-network approach for approximating high-dimensional probability density via empirical distribution. This leverages randomized singular value decomposition (SVD) techniques and involves solving linear …
  24. Density-Matrix Renormalization Group Algorithm for Simulating Quantum Circuits with a Finite Fidelity

    Publication
    We develop a density-matrix renormalization group (DMRG) algorithm for the simulation of quantum circuits. This algorithm can be seen as the extension of the time-dependent DMRG …
  25. Narrowband gamma oscillations propagate and synchronize throughout the mouse thalamocortical visual system.

    Publication
  26. Noninvasive metabolic profiling of cumulus cells, oocytes, and embryos via fluorescence lifetime imaging microscopy: a mini-review

    Publication
    A major challenge in ART is to select high-quality oocytes and embryos. The metabolism of oocytes and embryos has long been linked to their viability, suggesting the …
  27. The spontaneous symmetry breaking in Ta2NiSe5 is structural in nature

    Publication
  28. Exchange torque in noncollinear spin density functional theory with a semilocal exchange functional

    Publication
  29. Quantum Embedding Method for the Simulation of Strongly Correlated Systems on Quantum Computers

    Publication
  30. Floquet engineering with quantum optimal control theory

    Publication
  31. Ultrafast electron localization and screening in a transition metal dichalcogenide

    Publication
  32. Floquet Engineering of Magnetism in Topological Insulator Thin Films

    Publication
  33. Metal–insulator transition in composition-tuned nickel oxide films

    Publication
  34. Orbital polarization, charge transfer, and fluorescence in reduced-valence nickelates

    Publication
  35. Spatial frequency selectivity in macaque LGN and V1

    Publication
    … this model to the observed neuronal responses. The model implements divisive normalization, a canonical computation in cortical processing that accounts for a wide variety of observed neural …
  36. Visual processing in genetic conditions linked to autism: A behavioral study of binocular rivalry in individuals with 16p11.2 deletions and age-matched controls.

    Publication
  37. Consistency and reliability of automated language measures across expressive language samples in autism.

    Publication
  38. Rhythmic and interval-based temporal orienting in autism.

    Publication
  39. Sex differences in autism: Examining intrinsic and extrinsic factors in children and adolescents enrolled in a national ASD cohort.

    Publication
  40. Characterizing sleep problems in 16p11.2 deletion and duplication.

    Publication
  41. Dissipation and energy propagation across scales in an active cytoskeletal material

    Publication
    Living systems are intrinsically nonequilibrium: They use metabolically derived chemical energy to power their emergent dynamics and self-organization. A crucial driver of these dynamics is the cellular …
  42. Electrophysiological indices of hierarchical speech processing differentially reflect the comprehension of speech in noise.

    Publication
  43. Locomotion-induced gain of visual responses cannot explain visuomotor mismatch responses in layer 2/3 of primary visual cortex

    Publication
  44. High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways.

    Publication
  45. Folding and modulation of the helical conformation of Glycophorin A by point mutations

    Publication
    … transmembrane proteins that have physiological relevance.
  46. Docking cholesterol to integral membrane proteins with Rosetta

    Publication
    Lipid molecules such as cholesterol interact with the surface of integral membrane proteins (IMP) in a mode different from drug-like molecules in a protein binding pocket. These …
  47. Collective Motion and Pattern Formation in Phase-Synchronizing Active Fluids

    Publication
    Many active particles, such as swimming micro-organisms or motor proteins, do work on their environment by going though a periodic sequence of shapes. Interactions between particles can …
  48. Time-resolved correlation of distributed brain activity tracks E-I balance and accounts for diverse scale-free phenomena

    Publication
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