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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Comparing autism phenotypes in children born extremely preterm and born at term.

    Publication
  2. Processing of social and monetary rewards in autism spectrum disorders.

    Publication
  3. Cardiovascular disease risk factors in autistic adults: The impact of sleep quality and antipsychotic medication use.

    Publication
  4. Anillin Related Mid1 as an Adaptive and Multimodal Contractile Ring Anchoring Protein: A Simulation Study

    Publication
    The organization of the cytokinetic ring at the cell equator of dividing animal and fungi cells depends crucially on the anillin scaffold proteins. In fission yeast, anillin related …
  5. Flow-network-controlled shape transformation of a thin membrane through differential fluid storage and surface expansion

    Publication
    The mechanical properties of a thin, planar material, perfused by an embedded flow network, have been suggested to be potentially changeable locally and globally by fluid transport and …
  6. Neural Plasticity in Sensorimotor Brain-Machine Interfaces

    Publication
  7. Blood RNA alternative splicing events as diagnostic biomarkers for infectious disease

    Publication
    Assays detecting blood transcriptome changes are studied for infectious disease diagnosis. Blood-based RNA alternative splicing (AS) events, which have not been well characterized in pathogen infection, have …
  8. Evaluating causal psychological models: A study of language theories of autism using a large sample.

    Publication
  9. Epilepsy-associated SCN2A (NaV1.2) variants exhibit diverse and complex functional properties.

    Publication
  10. Fusome topology and inheritance during insect gametogenesis

    Publication
    From insects to mammals, oocytes and sperm develop within germline cysts comprising cells connected by intercellular bridges (ICBs). In numerous insects, formation of the cyst is accompanied by …
  11. A searchable image resource of Drosophila GAL4-driver expression patterns with single neuron resolution

    Publication
  12. Abstract representations emerge naturally in neural networks trained to perform multiple tasks

    Publication
  13. Subcortical brain alterations in carriers of genomic copy number variants.

    Publication
  14. Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis

    Publication
    Periodontal disease is more common in individuals with rheumatoid arthritis (RA) who have detectable anti-citrullinated protein antibodies (ACPAs), implicating oral mucosal inflammation in RA pathogenesis. Here, we …
  15. Categorical versus dimensional structure of autism spectrum disorder: A multi-method investigation.

    Publication
  16. Linear Convergence of Natural Policy Gradient Methods with Log-Linear Policies

    Publication
    We consider infinite-horizon discounted Markov decision processes and study the convergence rates of the natural policy gradient (NPG) and the Q-NPG methods with the log-linear …
  17. A SPECT-based method for dynamic imaging of the glymphatic system in rats

    Publication
  18. Encoding of dynamic facial information in the middle dorsal face area

    Publication
  19. Connection between MHC class II binding and aggregation propensity: The antigenic peptide 10 of Paracoccidioides brasiliensis as a benchmark study

    Publication
    The aggregation of epitopes that are also able to bind major histocompatibility complex (MHC) alleles raises questions around the potential connection between the formation of epitope aggregates and …
  20. Connection between MHC class II binding and aggregation propensity: The antigenic peptide 10 of Paracoccidioides brasiliensis as a benchmark study

    Publication
    The aggregation of epitopes that are also able to bind major histocompatibility complex (MHC) alleles raises questions around the potential connection between the formation of epitope aggregates and …
  21. Omicron mutations increase interdomain interactions and reduce epitope exposure in the SARS-CoV-2 spike

    Publication
    Omicron BA.1 is a highly infectious variant of SARS-CoV-2 that carries more than thirty mutations on the spike protein in comparison to the Wuhan wild …
  22. The Shrinkage-Delinkage Trade-off: An Analysis of Factorized Gaussian Approximations for Variational Inference

    Publication
    When factorized approximations are used for variational inference (VI), they tend to underestimate the uncertainty -- as measured in various ways -- of the distributions they are meant to approximate …
  23. Omicron mutations increase interdomain interactions and reduce epitope exposure in the SARS-CoV-2 spike

    Publication
    Omicron BA.1 is a highly infectious variant of SARS-CoV-2 that carries more than thirty mutations on the spike protein in comparison to the Wuhan wild …
  24. Macroscopic dynamics of neural networks with heterogeneous spiking thresholds

    Publication
  25. Hypothalamic neurons that mirror aggression

    Publication
  26. Therapeutic strategies for autism: Targeting three levels of the central dogma of molecular biology.

    Publication
  27. Emergent properties of collective gene-expression patterns in multicellular systems

    Publication
    Multicellular organisms contain diverse tissues built from multiple cell types. It remains unclear how large numbers of interacting cells can precisely coordinate their gene expression during tissue self …
  28. Mice and primates use distinct strategies for visual segmentation

    Publication
  29. Excessive proteostasis contributes to pathology in fragile X syndrome.

    Publication
  30. (An)isotropy measurement with gravitational wave observations

    Publication
    We constrain the distribution of merging compact binaries across the celestial sphere using the GWTC-3 catalog from the LIGO-Virgo-KAGRA Collaborations' (LVK) third observing run. With …
  31. Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages

    Publication
  32. Profiles of circumscribed interests in autistic youth.

    Publication
  33. Anatomical biology guides a search for nutrients for the aging brain

    Publication
  34. Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation

    Publication
  35. Metacognitive computations for information search: Confidence in control

    Publication
  36. Multiple polarity kinases inhibit phase separation of F-BAR protein Cdc15 and antagonize cytokinetic ring assembly in fission yeast

    Publication
    The F-BAR protein Cdc15 is essential for cytokinesis in Schizosaccharomyces pombe and plays a key role in attaching the cytokinetic ring (CR) to the plasma membrane (PM …
  37. PETSc/TAO Users Manual Revision 3.18

    Publication
    This manual describes the use of the Portable, Extensible Toolkit for Scientific Computation (PETSc) and the Toolkit for Advanced Optimization (TAO) for the numerical solution of partial differential …
  38. Hypothalamic neurons that mirror aggression

    Publication
  39. A transcriptional constraint mechanism limits the homeostatic response to activity deprivation in mammalian neocortex.

    Publication
  40. De novo human brain enhancers created by single nucleotide mutations.

    Publication
  41. Glymphatic-assisted perivascular brain delivery of intrathecal small gold nanoparticles

    Publication
  42. Integration of structural MRI and epigenetic analyses hint at linked cellular defects of the subventricular zone and insular cortex in autism: Findings from a case study.

    Publication
  43. Patterning potential of the terminal system in the Drosophila embryo

    Publication
    Segmentation of the Drosophila embryo is initiated by localized maternal signals. In this context, anteriorly localized Bicoid activates the gap genes in the anterior half of the embryo …
  44. IAN: Iterated Adaptive Neighborhoods for Manifold Learning and Dimensionality Estimation

    Publication
  45. Novel maternal autoantibodies in autism spectrum disorder: Implications for screening and diagnosis.

    Publication
  46. Social-interactive reward elicits similar neural response in autism and typical development and predicts future social experiences.

    Publication
  47. Quantum correlation of electron and ion energy in the dissociative strong-field ionization of H

    Publication
  48. Semiclassical bounds on the dynamics of two-dimensional interacting disordered fermions

    Publication
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