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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Semiclassical bounds on the dynamics of two-dimensional interacting disordered fermions

    Publication
  2. Time-based Chern number in periodically driven systems in the adiabatic limit

    Publication
  3. Role of electronic correlations in the kagome-lattice superconductor LaRh

    Publication
  4. Accurate Relativistic Real-Time Time-Dependent Density Functional Theory for Valence and Core Attosecond Transient Absorption Spectroscopy

    Publication
  5. SP2 : A Second Order Stochastic Polyak Method

    Publication
    Recently the SP (Stochastic Polyak step size) method has emerged as a competitive adaptive method for setting the step sizes of SGD. SP can be interpreted as a …
  6. A fast method for imposing periodic boundary conditions on arbitrarily-shaped lattices in two dimensions

    Publication
    A new scheme is presented for imposing periodic boundary conditions on unit cells with arbitrary source distributions. We restrict our attention here to the Poisson, modified Helmholtz, Stokes …
  7. On the robustness of inverse scattering for penetrable, homogeneous objects with complicated boundary

    Publication
    The acoustic inverse obstacle scattering problem consists of determining the shape of a domain from measurements of the scattered far field due to some set of incident fields …
  8. Sensitivity to naturalistic texture relies primarily on high spatial frequencies

    Publication
  9. Stable Solid Molecular Hydrogen above 900 K from a Machine-Learned Potential Trained with Diffusion Quantum Monte Carlo

    Publication
  10. Tackling hypo and hyper sensory processing heterogeneity in autism: From clinical stratification to genetic pathways.

    Publication
  11. The network structure of the special interests survey.

    Publication
  12. Failure to consolidate statistical learning in developmental dyslexia.

    Publication
  13. A predictive ensemble classifier for the gene expression diagnosis of ASD at ages 1 to 4 years.

    Publication
  14. Theory of mind in naturalistic conversations between autistic and typically developing children and adolescents.

    Publication
  15. Predictors of expert providers' familiarity with intervention practices for school- and transition-age youth with autism spectrum disorder.

    Publication
  16. Moderators of age of diagnosis in > 20,000 females with autism in two large us studies.

    Publication
  17. Genetic control of mRNA splicing as a potential mechanism for incomplete penetrance of rare coding variants.

    Publication
  18. Live Imaging of Nurse Cell Behavior in Late Stages of Drosophila Oogenesis

    Publication
    Drosophila oogenesis is a powerful and tractable model for studies of cell and developmental biology due to the multitude of well-characterized events in both germline and somatic …
  19. HAT: de novo variant calling for highly accurate short-read and long-read sequencing data.

    Publication
  20. Quantifying constraint in human mitochondrial DNA.

    Publication
  21. Handbook of Convergence Theorems for (Stochastic) Gradient Methods

    Publication
    This is a handbook of simple proofs of the convergence of gradient and stochastic gradient descent type methods. We consider functions that are Lipschitz, smooth, convex, strongly convex …
  22. Dimerization of the Alzheimer's disease pathogenic receptor SORLA regulates its association with retromer

    Publication
  23. Hierarchical architecture of dopaminergic circuits enables second-order conditioning in Drosophila

    Publication
  24. Interaction studies of risk proteins in human induced neurons reveal convergent biology and novel mechanisms underlying autism spectrum disorders.

    Publication
  25. Neuromotor repertoires in infants exposed to maternal COVID-19 during pregnancy: a cohort study.

    Publication
  26. Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making

    Publication
  27. Fluorescent azobenzene-confined coiled-coil mesofibers

    Publication
    Fluorescent protein biomaterials have important applications such as bioimaging in pharmacological studies. Self-assembly of proteins, especially into fibrils, is known to produce fluorescence in the blue band …
  28. Optimal Quadratic Binding for Relational Reasoning in Vector Symbolic Neural Architectures

    Publication
  29. Identifying foetal forebrain interneurons as a target for monogenic autism risk factors and the polygenic 16p11.2 microdeletion.

    Publication
  30. Lack of accelerated ovarian aging in a follicle-stimulating hormone receptor haploinsufficiency mode

    Publication
  31. Dynamics of Flexible Filaments in Oscillatory Shear Flows

    Publication
    The fluid–structure interactions between flexible fibres and viscous flows play an essential role in various biological phenomena, medical problems and industrial processes. Of particular interest is the …
  32. Spontaneous behaviour is structured by reinforcement without explicit reward

    Publication
  33. Relating pathogenic loss-of-function mutations in humans to their evolutionary fitness costs.

    Publication
  34. Steps of actin filament branch formation by Arp2/3 complex investigated with coarse-grained molecular dynamics

    Publication
    The nucleation of actin filament branches by the Arp2/3 complex involves activation through nucleation promotion factors (NPFs), recruitment of actin monomers, and binding of the complex to …
  35. Transcriptional vulnerabilities of striatal neurons in human and rodent models of Huntington's disease.

    Publication
  36. Blood-to-brain communication in aging and rejuvenation

    Publication
  37. A neural substrate of sex-dependent modulation of motivation

    Publication
  38. A fast, high-order numerical method for the simulation of single-excitation states in quantum optics

    Publication
    We consider the numerical solution of a nonlocal partial differential equation which models the process of collective spontaneous emission in a two-level atomic system containing a single …
  39. Parametric control of flexible timing through low-dimensional neural manifolds

    Publication
  40. Autistic adults show intact learning on a visuospatial serial reaction time task.

    Publication
  41. All-optical physiology resolves a synaptic basis for behavioral timescale plasticity

    Publication
  42. Coordinated drift of receptive fields in Hebbian/anti-Hebbian network models during noisy representation learning

    Publication
    Recent experiments have revealed that neural population codes in many brain areas continuously change even when animals have fully learned and stably perform their tasks. This representational ‘drift …
  43. Astrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons

    Publication
  44. Residual dynamics resolves recurrent contributions to neural computation

    Publication
  45. ASD modelling in organoids reveals imbalance of excitatory cortical neuron subtypes during early neurogenesis.

    Publication
  46. Examining the latent structure and correlates of sensory reactivity in autism: a multi-site integrative data analysis by the autism sensory research consortium.

    Publication
  47. Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes

    Publication
  48. Screening, diagnosis, and intervention for autism: Experiences of black and multiracial families seeking care.

    Publication
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