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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. The importance of low IQ to early diagnosis of autism.

    Publication
  2. Cortical-subcortical interactions in goal-directed behavior.

    Publication
  3. Complexity analysis of head movements in autistic toddlers.

    Publication
  4. Assessing evidence accumulation and rule learning in humans with an online game.

    Publication
  5. The combination of autism and exceptional cognitive ability is associated with suicidal ideation.

    Publication
  6. The centrality of population-level factors to network computation is demonstrated by a versatile approach for training spiking networks

    Publication
  7. Dimensionality reduction of calcium-imaged neuronal population activity

    Publication
  8. Dynamic regulation of gonadal transposon control across the lifespan of the naturally short-lived African turquoise killifish

    Publication
  9. Epithelia delimits glial apical polarity against mechanical shear to maintain glia-neuron architecture.

    Publication
  10. Patterns of connectome variability in autism across five functional activation tasks. Findings from the leap project.

    Publication
  11. A geometrical connection between sparse and low-rank matrices and its application to manifold learning

    Publication
    We consider when a sparse nonnegative matrix (mathbf{S}) can be recovered, via an elementwise nonlinearity, from a real-valued matrix~ (mathbf{S}) of significantly lower rank. Of …
  12. PELICAN: Permutation Equivariant and Lorentz Invariant or Covariant Aggregator Network for Particle Physics

    Publication
    Many current approaches to machine learning in particle physics use generic architectures that require large numbers of parameters and disregard underlying physics principles, limiting their applicability as scientific …
  13. Systematic multi-trait AAV capsid engineering for efficient gene delivery.

    Publication
  14. The role of the lateral orbitofrontal cortex in creating cognitive maps

    Publication
  15. A brainstem integrator for self-location memory and positional homeostasis in zebrafish

    Publication
  16. Face familiarity detection with complex synapses

    Publication
  17. A subphenotype-to-genotype approach reveals disproportionate megalencephaly autism risk genes.

    Publication
  18. Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of fragile X syndrome.

    Publication
  19. Characterizing Observed Extra Mixing Trends in Red Giants using the Reduced Density Ratio from Thermohaline Models

    Publication
    Observations show an almost ubiquitous presence of extra mixing in low-mass upper giant branch stars. The most commonly invoked explanation for this is thermohaline mixing. One-dimensional …
  20. Neural ensembles in navigation: From single cells to population codes

    Publication
  21. Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain

    Publication
  22. Minimum perturbation theory of deep perceptual learning

    Publication
  23. Associative memory of structured knowledge

    Publication
  24. Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies

    Publication
  25. "Super-Kilonovae" from Massive Collapsars as Signatures of Black-Hole Birth in the Pair-instability Mass Gap

    Publication
    The core collapse of rapidly rotating massive ∼ 10M⊙ stars ("collapsars"), and the resulting formation of hyperaccreting black holes, comprise a leading model for the central engines of long …
  26. Sleep problems and autism impairments in a large community sample of children and adolescents.

    Publication
  27. Social attention during object engagement: Toward a cross-species measure of preferential social orienting.

    Publication
  28. Cortical-hippocampal coupling during manifold exploration in motor cortex

    Publication
  29. Sparse RNNs can support high-capacity classification

    Publication
  30. An in vivo platform for rebuilding functional neocortical tissue.

    Publication
  31. CHD8 suppression impacts on histone h3 lysine 36 trimethylation and alters rna alternative splicing.

    Publication
  32. The case for a minute-long merger-driven gamma-ray burst from fast-cooling synchrotron emission

    Publication
    For decades, gamma-ray bursts (GRBs) have been broadly divided into `long'- and `short'-duration bursts, lasting more or less than 2s, respectively. However, this dichotomy does not …
  33. A Kilonova Following a Long-Duration Gamma-Ray Burst at 350 Mpc

    Publication
    Here, we report the discovery of a kilonova associated with the nearby (350 Mpc) minute-duration GRB 211211A. In tandem with deep optical limits that rule out the …
  34. Patterned cPCDH expression regulates the fine organization of the neocortex.

    Publication
  35. Cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment

    Publication
  36. Circulating Klotho Is Higher in Cerebrospinal Fluid than Serum and Elevated Among KLOTHO Heterozygotes in a Cohort with Risk for Alzheimer's Disease

    Publication
  37. AD-associated CSF biomolecular changes are attenuated in KL-VS heterozygotes

    Publication
  38. A measurement of the distance to the Galactic centre using the kinematics of bar stars

    Publication
    The distance to the Galactic center R0 is a fundamental parameter for understanding the Milky Way, because all observations of our Galaxy are made from our heliocentric reference …
  39. The impact of quality control on cortical morphometry comparisons in autism.

    Publication
  40. Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes

    Publication
  41. A large-scale neural network training framework for generalized estimation of single-trial population dynamics

    Publication
  42. Input correlations impede suppression of chaos and learning in balanced firing-rate networks

    Publication
  43. Fluid circulation driven by collectively organized metachronal waves in swimming T. aceti nematodes

    Publication
    Recent experiments have shown that the nematode {it T. aceti} can assemble into collectively undulating groups at the edge of fluid drops. This coordinated state consists of metachronal …
  44. Replacement dynamics and the pathogenesis of the Alpha, Delta and Omicron variants of SARS-CoV-2

    Publication
    … the incubation periods were: Alpha 11.19 (95% CrI 10.92-11.48) days; Delta 9.97 (95% CrI 9.73-10.21) days; Delta Plus 9 …
  45. Fine-tuning hierarchical circuits through learned stochastic co-modulation

    Publication
    Attentional gating is a core mechanism supporting behavioral flexibility, but its biological implementation remains uncertain. Gain modulation of neural responses is likely to play a key role, but …
  46. Maximum a posteriori natural scenes reconstruction from retinal ganglion cells with deep denoiser priors

    Publication
    Visual information arriving at the retina is transmitted to the brain by signals in the optic nerve, and the brain must rely solely on these signals to make …
  47. Superconductivity in the uniform electron gas: Irrelevance of the Kohn-Luttinger mechanism

    Publication
  48. Dynamic Response of an Electron Gas: Towards the Exact Exchange-Correlation Kernel

    Publication
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