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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Designer meron lattice on the surface of a topological insulator

    Publication
  2. Taming pseudofermion functional renormalization for quantum spins: Finite temperatures and the Popov-Fedotov trick

    Publication
  3. Quantum physics in connected worlds

    Publication
  4. Chemical reactivity under collective vibrational strong coupling

    Publication
  5. Thermal critical points from competing singlet formations in fully frustrated bilayer antiferromagnets

    Publication
  6. Global metabolic profiles in a non-human primate model of maternal immune activation: Implications for neurodevelopmental disorders.

    Publication
  7. Using developmental regression to reorganize the clinical importance of autistic atypicalities.

    Publication
  8. Optimal Quadratic Binding for Relational Reasoning in Vector Symbolic Neural Architectures

    Publication
  9. Autism incidence and spatial analysis in more than 7 million pupils in English schools: A retrospective, longitudinal, school registry study.

    Publication
  10. Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity.

    Publication
  11. Concurrent ARFI Plaque Imaging and Wall Shear Stress Measurement in Human Carotid Artery, with Validation by Fluid Structure Interaction Model.

    Publication
    The rupture potential of an atherosclerotic plaque is dependent on both the plaque's composition and the shear stresses it encounters from blood flow. Because plaques move and …
  12. Could dexmedetomidine be repurposed as a glymphatic enhancer?

    Publication
  13. Reduced social attention in autism is magnified by perceptual load in naturalistic environments.

    Publication
  14. Shank2/3 double knockout-based screening of cortical subregions links the retrosplenial area to the loss of social memory in autism spectrum disorders.

    Publication
  15. Approximating the Gaussian as a Sum of Exponentials and Its Applications to the Fast Gauss Transform

    Publication
    We develop efficient and accurate sum-of-exponential (SOE) approximations for the Gaussian using rational approximation of the exponential function on the negative real axis. Six digit accuracy …
  16. The brief observation of symptoms of autism (BOSA): Development of a new adapted assessment measure for remote telehealth administration through COVID-19 and beyond.

    Publication
  17. Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity.

    Publication
  18. Corner Cases of the Generalized Tau Method

    Publication
    Polynomial spectral methods provide fast, accurate, and flexible solvers for broad ranges of PDEs with one bounded dimension, where the incorporation of general boundary conditions is well understood …
  19. Quantum Initial Conditions for Curved Inflating Universes

    Publication
    We discuss the challenges of motivating, constructing, and quantising a canonically-normalised inflationary perturbation in spatially curved universes. We show that this has historically proved challenging due to …
  20. Developmental trajectory of episodic-like memory in rats.

    Publication
  21. Coordinated multiplexing of information about separate objects in visual cortex

    Publication
  22. All-sky search for continuous gravitational waves from isolated neutron stars using Advanced LIGO and Advanced Virgo O3 data

    Publication
    We present results of an all-sky search for continuous gravitational waves which can be produced by spinning neutron stars with an asymmetry around their rotation axis, using …
  23. Modeling and inference methods for switching regime-dependent dynamical systems with multiscale neural observations

    Publication
  24. Unraveling the Entangled Brain: How Do We Go About It?

    Publication
  25. A new theoretical framework jointly explains behavioral and neural variability across subjects performing flexible decision-making.

    Publication
  26. Accurate in silico confirmation of rare copy number variant calls from exome sequencing data using transfer learning.

    Publication
  27. An FMM Accelerated Poisson Solver for Complicated Geometries in the Plane using Function Extension

    Publication
    We describe a new, adaptive solver for the two-dimensional Poisson equation in complicated geometries. Using classical potential theory, we represent the solution as the sum of a …
  28. Transcriptional diversity in synaptic gene sets is sufficient to discriminate cortical neuronal identity.

    Publication
  29. Cortical wiring by synapse-specific control of local protein synthesis.

    Publication
  30. A deep learning framework for inference of single-trial neural population dynamics from calcium imaging with subframe temporal resolution

    Publication
  31. B lymphocytes ameliorate Alzheimer's disease-like neuropathology via interleukin-35

    Publication
  32. Quantitative fate mapping: Reconstructing progenitor field dynamics via retrospective lineage barcoding.

    Publication
  33. The tricky business of defining brain functions

    Publication
  34. SARS-CoV-2 Outbreak Dynamics in an Isolated US Military Recruit Training Center With Rigorous Prevention Measures

    Publication
    Marine recruits training at Parris Island experienced an unexpectedly high rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, despite preventive measures including a supervised …
  35. A closer look at supernovae as seeds for galactic magnetization

    Publication
    Explaining the currently observed magnetic fields in galaxies requires relatively strong seeding in the early Universe. One theory proposes that magnetic fields of the order of μG were …
  36. pmwd: A Differentiable Cosmological Particle-Mesh N-body Library

    Publication
    The formation of the large-scale structure, the evolution and distribution of galaxies, quasars, and dark matter on cosmological scales, requires numerical simulations. Differentiable simulations provide gradients of …
  37. Differentiable Cosmological Simulation with Adjoint Method

    Publication
    Rapid advances in deep learning have brought not only myriad powerful neural networks, but also breakthroughs that benefit established scientific research. In particular, automatic differentiation (AD) tools and …
  38. Sex-specific neurodevelopmental outcomes in offspring of mothers with SARS-CoV-2 in pregnancy: An electronic health records cohort.

    Publication
  39. A single-cell trajectory atlas of striatal development.

    Publication
  40. Identifying genes and pathways linking astrocyte regional specificity to Alzheimer’s disease susceptibility

    Publication
    Astrocytes have been shown to play a central role in Alzheimer’s Disease (AD). However, the genes and biological pathways underlying disease manifestation are unknown, and it is …
  41. Cell type-specific assessment of cholesterol distribution in models of neurodevelopmental disorders.

    Publication
  42. Charting Galactic Accelerations with Stellar Streams and Machine Learning

    Publication
    We present a data-driven method for reconstructing the galactic acceleration field from phase-space measurements of stellar streams. Our approach is based on a flexible and differentiable …
  43. Learning Feynman Diagrams with Tensor Trains

    Publication
    We use tensor network techniques to obtain high-order perturbative diagrammatic expansions for the quantum many-body problem at very high precision. The approach is based on a …
  44. Systematic reduction of the dimensionality of natural scenes allows accurate predictions of retinal ganglion cell spike outputs

    Publication
  45. Ascertaining cells' synaptic connections and RNA expression simultaneously with barcoded rabies virus libraries

    Publication
  46. Theory of sleep/wake cycles affecting brain elastography

    Publication
  47. How to Design Peptides

    Publication
    Novel design of proteins to target receptors for treatment or tissue augmentation has come to the fore owing to advancements in computing power, modeling frameworks, and translational successes …
  48. Integrated gene analyses of de novo variants from 46,612 trios with autism and developmental disorders.

    Publication
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