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  • Bringing people and ideas together to fund, conduct, and share transformative science.

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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

Discover the latest news, research, and updates.

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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

Work with us on the frontier of basic science research.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. CYFIP1 dosages exhibit divergent behavioral impact via diametric regulation of NMDA receptor complex translation in mouse models of psychiatric disorders.

    Publication
  2. Gestationally-dependent immune organization at the maternal-fetal interface.

    Publication
  3. Sex-biasing influence of autism-associated Ube3a gene overdosage at connectomic, behavioral and transcriptomic levels.

    Publication
  4. Feature representation under crowding in macaque V1 and V4 neuronal populations

    Publication
  5. Heightened apoptotic priming of vascular cells across tissues and life span predisposes them to cancer therapy-induced toxicities

    Publication
  6. Developmental disruption and restoration of brain synaptome architecture in the murine Pax6 neurodevelopmental disease model.

    Publication
  7. AGN quenching in simulated dwarf galaxies

    Publication
    We examine the quenching characteristics of 328 isolated dwarf galaxies (108
  8. A short gamma-ray burst from a proto-magnetar remnant

    Publication
    The contemporaneous detection of gravitational waves and gamma rays from the GW170817/GRB 170817A, followed by kilonova emission a day after, confirmed compact binary neutron-star mergers as …
  9. An automated feeding system for the African killifish reveals effects of dietary restriction on lifespan and allows scalable assessment of associative learning

    Publication
  10. Anatomical biology guides a search for nutrients for the aging brain

    Publication
  11. Genomic architecture of autism from comprehensive whole-genome sequence annotation.

    Publication
  12. Mapping human social brain specialisation beyond the neuron using multimodal imaging in human infants.

    Publication
  13. Loss of neuronal Tet2 enhances hippocampal-dependent cognitive function

    Publication
  14. Incompressible active phases at an interface. Part 1. Formulation and axisymmetric odd flows

    Publication
    Inspired by the recent realization of a two-dimensional (2-D) chiral fluid as an active monolayer droplet moving atop a 3-D Stokesian fluid, we formulate mathematically …
  15. Copy number variation and structural genomic findings in 116 cases of sudden unexplained death between 1 and 28 months of age.

    Publication
  16. Neural Mechanisms that Make Perceptual Decisions Flexible

    Publication
  17. Neural circuit dynamics of drug-context associative learning in the mouse hippocampus

    Publication
  18. Refinements to rodent head fixation and fluid/food control for neuroscience

    Publication
  19. From Rats to Humans: how novel behavioral paradigms and reinforcement learning can bridge the gap in translation

    Publication
  20. Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types

    Publication
  21. Attractor and integrator networks in the brain

    Publication
  22. Angular Momentum Transport in Proto-Neutron Stars and the Fate of Neutron Star Merger Remnants

    Publication
    Both the core collapse of rotating massive stars, and the coalescence of neutron star (NS) binaries, result in the formation of a hot, differentially rotating NS remnant. The …
  23. A Sun-like star orbiting a black hole

    Publication
    We report discovery of a bright, nearby (G=13.8;d=480pc) Sun-like star orbiting a dark object. We identified the system as a black hole candidate …
  24. Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD.

    Publication
  25. The physical basis of self-organization of the mammalian oocyte spindle

    Publication
    To prepare gametes with the appropriate number of chromosomes, mammalian oocytes undergo two sequential cell divisions. During each division, a large, long-lived, microtubule-based organelle called the …
  26. Microglia states and nomenclature: A field at its crossroads

    Publication
  27. Microglia states and nomenclature: A field at its crossroads

    Publication
  28. Similar rates of deleterious copy number variants in early-onset psychosis and autism spectrum disorder.

    Publication
  29. Patterns of sleep disturbances and associations with depressive symptoms in autistic young adults.

    Publication
  30. Associations between co-occurring conditions and age of autism diagnosis: Implications for mental health training and adult autism research.

    Publication
  31. Accurate thermochemistry of covalent and ionic solids from spin-component-scaled MP2

    Publication
  32. Training biases in machine learning for the analytic continuation of quantum many-body Green's functions

    Publication
  33. High-Resolution EEG Source Reconstruction with Boundary Element Fast Multipole Method Using Reciprocity Principle and TES Forward Model Matrix

    Publication
    … source localization.Competing Interest StatementThe authors have declared no competing interest.
  34. Learning Feynman Diagrams with Tensor Trains

    Publication
  35. Real-space obstruction in quantum spin Hall insulators

    Publication
  36. Controlling Floquet states on ultrashort time scales

    Publication
  37. A structural optimization algorithm with stochastic forces and stresses

    Publication
  38. Sensory processing in 16p11.2 deletion and 16p11.2 duplication.

    Publication
  39. Ketamine induces multiple individually distinct whole-brain functional connectivity signatures.

    Publication
  40. Generation of DNA methylation signatures and classification of variants in rare neurodevelopmental disorders using epigencentral.

    Publication
  41. Pre-infection antiviral innate immunity contributes to sex differences in SARS-CoV-2 infection

    Publication
    Male sex is a major risk factor for SARS-CoV-2 infection severity. To understand the basis for this sex difference, we studied SARS-CoV-2 infection in …
  42. Intact amphetamine-induced behavioral sensitization in mice with increased or decreased neuronal glutamate transporter SLC1A1/EAAT3.

    Publication
  43. Co-occurring ADHD symptoms in autistic adults are associated with less independence in daily living activities and lower subjective quality of life.

    Publication
  44. Non-coding de novo mutations in chromatin interactions are implicated in autism spectrum disorder.

    Publication
  45. Behavioral responses to fevers and other medical events in children with and without ASD.

    Publication
  46. Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p.

    Publication
  47. libdlr: Efficient imaginary time calculations using the discrete Lehmann representation

    Publication
    We introduce libdlr, a library implementing the recently introduced discrete Lehmann representation (DLR) of imaginary time Green's functions. The DLR basis consists of a collection of exponentials …
  48. Imagination as a fundamental function of the hippocampus

    Publication
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