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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. KnockoffTrio: A knockoff framework for the identification of putative causal variants in genome-wide association studies with trio design.

    Publication
  2. Toward a Geometrical Understanding of Self-supervised Contrastive Learning

    Publication
    Self-supervised learning (SSL) is currently one of the premier techniques to create data representations that are actionable for transfer learning in the absence of human annotations. Despite …
  3. A PDE-free, neural network-based eddy viscosity model coupled with RANS equations

    Publication
    In fluid dynamics, constitutive models are often used to describe the unresolved turbulence and to close the Reynolds averaged Navier–Stokes (RANS) equations. Traditional PDE-based constitutive models …
  4. Tissue- and cell-type-specific molecular and functional signatures of 16p11.2 reciprocal genomic disorder across mouse brain and human neuronal models.

    Publication
  5. Glial control of sphingolipid levels sculpts diurnal remodeling in a circadian circuit

    Publication
  6. Recurrent neural networks with explicit representation of dynamic latent variables can mimic behavioral patterns in a physical inference task

    Publication
  7. The Neurodata Without Borders ecosystem for neurophysiological data science

    Publication
  8. Exclusion of females in autism research: Empirical evidence for a "leaky" recruitment-to-research pipeline.

    Publication
  9. Ultraflexible electrode arrays for months-long high-density electrophysiological mapping of thousands of neurons in rodents

    Publication
  10. GIGYF1 disruption associates with autism and impaired IGF-1R signaling.

    Publication
  11. Oxytocin enhances basolateral amygdala activation and functional connectivity while processing emotional faces: Preliminary findings in autistic vs non-autistic women.

    Publication
  12. Investigating the contributions of circadian pathway and insomnia risk genes to autism and sleep disturbances.

    Publication
  13. Generation and motion of interfaces in a mass-conserving reaction-diffusion system

    Publication
    Reaction-diffusion models with nonlocal constraints naturally arise as limiting cases of coupled bulk-surface models of intracellular signalling. In this paper, a minimal, mass-conserving model of …
  14. QuNex — An integrative platform for reproducible neuroimaging analytics.

    Publication
  15. Fragmented Cooper Pair Condensation in Striped Superconductors

    Publication
  16. Tunable stripe order and weak superconductivity in the Moiré Hubbard model

    Publication
  17. Class of distorted Landau levels and Hall phases in a two-dimensional electron gas subject to an inhomogeneous magnetic field

    Publication
  18. Compressed Sensing in the Presence of Speckle Noise

    Publication
    Speckle or multiplicative noise is a critical issue in coherence-based imaging systems, such as synthetic aperture radar and optical coherence tomography. Existence of speckle noise considerably limits …
  19. Entanglement and Charge-Sharpening Transitions in U(1) Symmetric Monitored Quantum Circuits

    Publication
  20. Simulating Terahertz Field-Induced Ferroelectricity in Quantum Paraelectric SrTiO

    Publication
  21. Aubry-André Anderson model: Magnetic impurities coupled to a fractal spectrum

    Publication
  22. Combinations of genes at the 16p11.2 and 22q11.2 CNVs contribute to neurobehavioral traits.

    Publication
  23. Reexamining empathy in autism: Empathic disequilibrium as a novel predictor of autism diagnosis and autistic traits.

    Publication
  24. Social attention in anorexia nervosa and autism spectrum disorder: Role of social motivation.

    Publication
  25. What are you looking at? Gaze following with and without target objects in asd and typical development.

    Publication
  26. Autistic mothers' perinatal well-being and parenting styles.

    Publication
  27. The primary ciliary deficits in cerebellar Bergmann glia of the mouse model of fragile X syndrome.

    Publication
  28. Mapping the time course of overt emotion dysregulation, self-injurious behavior, and aggression in psychiatrically hospitalized autistic youth: A naturalistic study.

    Publication
  29. Genome-wide by environment interaction study of stressful life events and hospital-treated depression in the iPSYCH2012 sample.

    Publication
  30. Prioritizing de novo autism risk variants with calibrated gene- and variant-scoring models.

    Publication
  31. SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline

    Publication
  32. High body mass polygenic risk in mothers enhances de novo functional mutations in epigenetic and microtubule gene pathways in their offspring with autism spectrum disorder.

    Publication
  33. Correcting motion induced fluorescence artifacts in two-channel neural imaging

    Publication
    … other methods of motion correction tested, the best of which were ~8x more accurate than control.
  34. Thalamus-driven functional populations in frontal cortex support decision-making

    Publication
    Neurons in frontal cortex exhibit diverse selectivity representing sensory, motor and cognitive variables during decision-making. The neural circuit basis for this complex selectivity remains unclear. We examined …
  35. Pretargeted Imaging beyond the Blood-Brain Barrier-Utopia or Feasible?

    Publication
  36. Motor cortical influence relies on task-specific activity covariation

    Publication
    During limb movement, spinal circuits facilitate the alternating activation of antagonistic flexor and extensor muscles. Yet antagonist cocontraction is often required to stabilize joints, like when loads are …
  37. Dopaminergic gene dosage reveals distinct biological partitions between autism and developmental delay as revealed by complex network analysis and machine learning approaches.

    Publication
  38. Atypical gaze patterns in autistic adults are heterogeneous across but reliable within individuals.

    Publication
  39. Cell-type specific transcriptomic signatures of neocortical circuit organization and their relevance to autism.

    Publication
  40. Deep learning for neural decoding in motor cortex

    Publication
    … network containing the concurrent ANN decoder outperformed single-network concurrent decoders.Significance. Taken together, our study demonstrates that deep learning could become a robust and effective method …
  41. Systematic evaluation of genome sequencing as a first-tier diagnostic test for prenatal and pediatric disorders.

    Publication
  42. Wireless multi-lateral optofluidic microsystems for real-time programmable optogenetics and photopharmacology

    Publication
    In vivo optogenetics and photopharmacology are two techniques for controlling neuronal activity that have immense potential in neuroscience research. Their applications in tether-free groups of animals have …
  43. Deep Learning the Functional Renormalization Group

    Publication
    We perform a data-driven dimensionality reduction of the scale-dependent four-point vertex function characterizing the functional renormalization group (FRG) flow for the widely studied two-dimensional …
  44. Liver-secreted fluorescent blood plasma markers enable chronic imaging of the microcirculation

    Publication
  45. Can we detect deep axisymmetric toroidal magnetic fields in stars?

    Publication
    One of the major discoveries of asteroseismology is the signature of a strong extraction of angular momentum (AM) in the radiative zones of stars across the entire Hertzsprung …
  46. Oocyte mitophagy is critical for extended reproductive longevity

    Publication
    Women's reproductive cessation is the earliest sign of human aging and is caused by decreasing oocyte quality. Similarly, C. elegans' reproduction declines in mid-adulthood and is …
  47. Independent response modulation of visual cortical neurons by attentional and behavioral states

    Publication
    Sensory processing is influenced by cognitive and behavioral states, but how these states interact to modulate responses of individual neurons is unknown. We trained mice in a visual …
  48. Synaptic balancing: A biologically plausible local learning rule that provably increases neural network noise robustness without sacrificing task performance

    Publication
    We introduce a novel, biologically plausible local learning rule that provably increases the robustness of neural dynamics to noise in nonlinear recurrent neural networks with homogeneous nonlinearities. Our …
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