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  1. A temporal sequence of thalamic activity unfolds at transitions in behavioral arousal state

    Publication
    Awakening from sleep reflects a profound transformation in neural activity and behavior. The thalamus is a key controller of arousal state, but whether its diverse nuclei exhibit coordinated …

  2. Multi-site normative modeling of diffusion tensor imaging metrics using hierarchical Bayesian regression.

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  3. Finite inflation in curved space

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    We investigate the effects of non-zero spatial curvature on cosmic inflation in the light of cosmic microwave background (CMB) anisotropy measurements from the Planck 2018 legacy release …

  4. Accurate de novo design of membrane-traversing macrocycles

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    We use computational design coupled with experimental characterization to systematically investigate the design principles for macrocycle membrane permeability and oral bioavailability. We designed 184 6–12 residue macrocycles …

  5. Cell-type-specific population dynamics of diverse reward computations

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    Computational analysis of cellular activity has developed largely independently of modern transcriptomic cell typology, but integrating these approaches may be essential for full insight into cellular-level mechanisms …

  6. An exploration of the properties of cluster profiles for the thermal and kinetic Sunyaev–Zel’dovich effects

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    With the advent of high-resolution, low-noise CMB measurements, the ability to extract cosmological information from thermal Sunyaev-Zel'dovich effect and kinetic Sunyaev-Zel'dovich effect …

  7. Robust ab initio solution of the cryo-EM reconstruction problem at low resolution with small data sets

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    Single particle cryo-electron microscopy has become a critical tool in structural biology over the last decade, able to achieve atomic scale resolution in three dimensional models from …

  8. Versatile treadmill system for measuring locomotion and neural activity in head-fixed mice

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    Here, we present a protocol for using a versatile treadmill system to measure locomotion and neural activity at high temporal resolution in head-fixed mice. We first describe …

  9. Quadrature by fundamental solutions: kernel-independent layer potential evaluation for large collections of simple objects

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    Well-conditioned boundary integral methods for the solution of elliptic boundary value problems (BVPs) are powerful tools for static and dynamic physical simulations. When there are many close …

  10. A real-time in vivo clearance assay for quantification of glymphatic efflux

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    Glymphatic fluid transport eliminates metabolic waste from the brain including amyloid-β, yet the methodology for studying efflux remains rudimentary. Here, we develop a method to evaluate glymphatic …

  11. ​​Striatal dopamine explains novelty-induced behavioral dynamics and individual variability in threat prediction

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    Animals both explore and avoid novel objects in the environment, but the neural mechanisms that underlie these behaviors and their dynamics remain uncharacterized. Here, we used multi-point …

  12. Focus on your locus with a massively parallel reporter assay.

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  13. Refinements to rodent head fixation and fluid/food control for neuroscience

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    The use of head fixation in mice is increasingly common in research, its use having initially been restricted to the field of sensory neuroscience. Head restraint has often …

  14. The caudal prethalamus: Inhibitory switchboard for behavioral control?

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    Prethalamic nuclei in the mammalian brain include the zona incerta, the ventral lateral geniculate nucleus, and the intergeniculate leaflet, which provide long-range inhibition to many targets in …

  15. Mechanics of stabilized intercellular bridges

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    Numerous engineered and natural systems form through reinforcement and stabilization of a deformed configuration that was generated by a transient force. An important class of such structures arises …

  16. Autism is associated with interindividual variations of gray and white matter morphology.

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  17. A capabilities approach to understanding and supporting autistic adulthood.

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  18. Adult fibroblasts use aggresomes only in distinct cell-states

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    The aggresome is a protein turnover system in which proteins are trafficked along microtubules to the centrosome for degradation. Despite extensive focus on aggresomes in immortalized cell lines …

  19. The role of monolayer viscosity in Langmuir film hole closure dynamics

    Publication
    We re-examine the model proposed by Alexander et al. (Phys. Fluids, vol. 18, 2006, 062103) for the closing of a circular hole in a molecularly thin incompressible …

  20. Normative theories of synaptic plasticity for representation and perceptual discrimination

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    … of normative theories of plasticity, both for conceptualizing learning in the brain and informing experiments that investigate adaptive neural circuits.

  21. A hidden population of massive black holes in simulated dwarf galaxies

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    We explore the characteristics of actively accreting MBHs within dwarf galaxies in the textsc{Romulus25} cosmological hydrodynamic simulation. We examine the MBH occupation fraction, x-ray active fractions …

  22. Floquet engineering the band structure of materials with optimal control theory

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  23. Wavefunction embedding for molecular polaritons

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  24. Valley selectivity of soft x-ray excitations of core electrons in two-dimensional transition metal dichalcogenides

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  25. Large-N theory of critical Fermi surfaces. II. Conductivity

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  26. Charge transfer in ultrafast isomerization of acetylene ions

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  27. Ultralocalized Optoelectronic Properties of Nanobubbles in 2D Semiconductors

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  28. Reprogramming the topology of the nociceptive circuit in C. elegans reshapes sexual behavior

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    The effect of the detailed connectivity of a neural circuit on its function and the resulting behavior of the organism is a key question in many neural systems …

  29. Developmental variability in autism across 17000 autistic individuals and 4000 siblings without an autism diagnosis: Comparisons by cohort, intellectual disability, genetic etiology, and age at diagnosis.

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  30. Rare variants and the oligogenic architecture of autism.

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  31. A phenotypic spectrum of autism is attributable to the combined effects of rare variants, polygenic risk and sex.

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  32. Examining the factor structure and discriminative utility of the infant behavior questionnaire-revised in infant siblings of autistic children.

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  33. Altered theta-beta ratio in infancy associates with family history of ADHD and later ADHD-relevant temperamental traits.

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  34. A Weighted State Redistribution Algorithm for Embedded Boundary Grids

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    State redistribution is an algorithm that stabilizes cut cells for embedded boundary grid methods. This work extends the earlier algorithm in several important ways. First, state redistribution is …

  35. Rare coding variation provides insight into the genetic architecture and phenotypic context of autism.

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  36. Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes.

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  37. The impact of birth order on language development in autistic children from Simplex families.

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  38. Genetic correlates of phenotypic heterogeneity in autism.

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  39. Measuring transcription factor binding and gene expression using barcoded self-reporting transposon calling cards and transcriptomes.

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  40. Production of MHCII-expressing classical monocytes increases during aging in mice and humans

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    Aging is associated with increased monocyte production and altered monocyte function. Classical monocytes are heterogenous and a shift in their subset composition may underlie some of their apparent …

  41. Behaviorally relevant decision coding in primary somatosensory cortex neurons

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    Primary sensory cortex is thought to process incoming sensory information, while decision variables important for driving behavior are assumed to arise downstream in the processing hierarchy. Here, we …

  42. Genome-wide analyses of individual differences in quantitatively assessed reading- and language-related skills in up to 34,000 people.

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  43. A follow-up on intermediate-mass black hole candidates in the second LIGO–Virgo observing run with the Bayes Coherence Ratio

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    The detection of an intermediate-mass black hole population (102−106 M⊙) will provide clues to their formation environments (e.g., disks of active galactic nuclei, globular clusters …

  44. Early life sleep disruption potentiates lasting sex-specific changes in behavior in genetically vulnerable Shank3 heterozygous autism model mice.

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  45. GATK-gCNV: A rare copy number variant discovery algorithm and its application to exome sequencing in the UK Biobank.

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  46. Rapid specification of human pluripotent stem cells to functional astrocytes.

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  47. Isoform-level transcriptome-wide association uncovers extensive novel genetic risk mechanisms for neuropsychiatric disorders in the human brain.

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  48. An Atlas of Convection in Main-sequence Stars

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    Convection is ubiquitous in stars and occurs under many different conditions. Here we explore convection in main-sequence stars through two lenses: dimensionless parameters arising from stellar structure …