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  1. A high-order integral equation-based solver for the time-dependent Schrödinger equation

    Publication
    We introduce a numerical method for the solution of the time-dependent Schrödinger equation with a smooth potential, based on its reformulation as a Volterra integral equation. We …

  2. Stochastic consolidation of lifelong memory

    Publication
    Humans have the remarkable ability to continually store new memories, while maintaining old memories for a lifetime. How the brain avoids catastrophic forgetting of memories due to interference …

  3. FMRP-dependent production of large dosage-sensitive proteins is highly conserved.

    Publication

  4. Bias in measurement of autism symptoms by spoken language level and non-verbal mental age in minimally verbal children with neurodevelopmental disorders.

    Publication

  5. Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability.

    Publication

  6. Neural network organization for courtship-song feature detection in Drosophila

    Publication
    Animals communicate using sounds in a wide range of contexts, and auditory systems must encode behaviorally relevant acoustic features to drive appropriate reactions. How feature detection emerges along …

  7. Nanoscale Femtosecond Dynamics of Mott Insulator (Ca0.99Sr0.01)2RuO4

    Publication

  8. Cortical feedback loops bind distributed representations of working memory

    Publication
    Working memory-the brain's ability to internalize information and use it flexibly to guide behaviour-is an essential component of cognition. Although activity related to working memory …

  9. On the stability of tidal streams in action space

    Publication
    In the Gaia era it is increasingly apparent that traditional static, parameterized models are insufficient to describe the mass distribution of our complex, dynamically evolving Milky Way (MW …

  10. Noise correlations in neural ensemble activity limit the accuracy of hippocampal spatial representations

    Publication
    Neurons in the CA1 area of the mouse hippocampus encode the position of the animal in an environment. However, given the variability in individual neurons responses, the accuracy …

  11. Multiple phase spirals suggest multiple origins in Gaia DR3

    Publication
    Gaia Data Release 2 revealed that the Milky Way contains significant indications of departures from equilibrium in the form of asymmetric features in the phase space density of …

  12. Deep embedded clustering by relevant scales and genome-wide association study in autism.

    Publication

  13. Single-cell RNA-seq of primary bone marrow neutrophils from female and male adult mice

    Publication
    Widespread sex-dimorphism is observed in the mammalian immune system. Consistently, studies have reported sex differences in the transcriptome of immune cells at the bulk level, including neutrophils …

  14. Psychometric validation of a brief self-report measure of misophonia symptoms and functional impairment: The duke-vanderbilt misophonia screening questionnaire.

    Publication

  15. Psychometric validation of a brief self-report measure of misophonia symptoms and functional impairment: The duke-vanderbilt misophonia screening questionnaire.

    Publication

  16. Canary in the cardiac-valve coal mine: Flow velocity and inferred shear during prosthetic valve closure –predictors of blood damage and clotting

    Publication
    To demonstrate a clear link between predicted blood shear forces during valve closure and thrombogenicity that explains the thrombogenic difference between tissue and mechanical valves and provides a …

  17. A microengineered Brain-Chip to model neuroinflammation in humans

    Publication
    Species differences in brain and blood-brain barrier (BBB) biology hamper the translation of findings from animal models to humans, impeding the development of therapeutics for brain diseases …

  18. The spectrum of covariance matrices of randomly connected recurrent neuronal networks with linear dynamics

    Publication
    A key question in theoretical neuroscience is the relation between the connectivity structure and the collective dynamics of a network of neurons. Here we study the connectivity-dynamics …

  19. The application of artificial intelligence to biology and neuroscience

    Publication
    Over the last decade, the artificial intelligence (AI) has undergone a revolution that is poised to transform the economy, society, and science. The pace of progress is staggering …

  20. Ageing and rejuvenation of tissue stem cells and their niches

    Publication
    Most adult organs contain regenerative stem cells, often organized in specific niches. Stem cell function is critical for tissue homeostasis and repair upon injury, and it is dependent …

  21. Neuroscience Cloud Analysis As a Service: An open-source platform for scalable, reproducible data analysis

    Publication
    A key aspect of neuroscience research is the development of powerful, general-purpose data analyses that process large datasets. Unfortunately, modern data analyses have a hidden dependence upon …

  22. Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex.

    Publication

  23. Data-driven Derivation of Stellar Properties from Photometric Time Series Data Using Convolutional Neural Networks

    Publication
    Stellar variability is driven by a multitude of internal physical processes that depend on fundamental stellar properties. These properties are our bridge to reconciling stellar observations with stellar …

  24. Independently paced Ca2+ oscillations in progenitor and differentiated cells in an ex vivo epithelial organ

    Publication
    Cytosolic Ca2+ is a highly dynamic, tightly regulated and broadly conserved cellular signal. Ca2+ dynamics have been studied widely in cellular monocultures, yet organs in vivo comprise heterogeneous …

  25. Polygenic architecture of rare coding variation across 400,000 exomes.

    Publication

  26. Epilepsy-related CDKL5 deficiency slows synaptic vesicle endocytosis in central nerve terminals.

    Publication

  27. Imbalance of flight-freeze responses and their cellular correlates in the Nlgn3−/y rat model of autism.

    Publication

  28. Electric Field Screening in Pair Discharges and Generation of Pulsar Radio Emission

    Publication
    Pulsar radio emission may be generated in pair discharges that fill the pulsar magnetosphere with plasma as an accelerating electric field is screened by freshly created pairs. In …

  29. Evaluating the Conformations and Dynamics of Peptoid Macrocycles

    Publication
    Peptoid macrocycles are versatile and chemically diverse peptidomimetic oligomers. However, the conformations and dynamics of these macrocycles have not been evaluated comprehensively and require extensive further investigation. Recent …

  30. Abnormal whisker-dependent behaviors and altered cortico-hippocampal connectivity in Shank3b-/- mice.

    Publication

  31. Selective representations of texture and motion in mouse higher visual areas

    Publication
    The mouse visual cortex contains interconnected higher visual areas, but their functional specializations are unclear. Here, we used a data-driven approach to examine the representations of complex …

  32. A sequence-based global map of regulatory activity for deciphering human genetics

    Publication
    Epigenomic profiling has enabled large-scale identification of regulatory elements, yet we still lack a systematic mapping from any sequence or variant to regulatory activities. We address this …

  33. Active Microphase Separation in Mixtures of Microtubules and Tip-Accumulating Molecular Motors

    Publication
    Mixtures of filaments and molecular motors form active materials with diverse dynamical behaviors that vary based on their constituents’ molecular properties. To develop a multiscale of these materials …

  34. Human iPSC-derived neuron of 16p11.2 deletion reveals haplotype-specific expression of MAPK3 and its contribution to variable NDD phenotypes.

    Publication

  35. Weakly nonlinear analysis of pattern formation in active suspensions

    Publication
    We consider the Saintillan--Shelley kinetic model of active rodlike particles in Stokes flow (Saintillan & Shelley 2008a,b), for which the uniform, isotropic suspension of pusher particles is …

  36. Copy number variation at the 22q11.2 locus influences prevalence, severity, and psychiatric impact of sleep disturbance.

    Publication

  37. Postmortem Human Dura Mater Cells Exhibit Phenotypic, Transcriptomic and Genetic Abnormalities that Impact their Use for Disease Modeling

    Publication
    Patient-derived cells hold great promise for precision medicine approaches in human health. Human dermal fibroblasts have been a major source of cells for reprogramming and differentiating into …

  38. Theory of the Multiregional Neocortex: Large-Scale Neural Dynamics and Distributed Cognition

    Publication
    The neocortex is a complex neurobiological system with many interacting regions. How these regions work together to subserve flexible behavior and cognition has become increasingly amenable to rigorous …

  39. Neural Algorithms and Circuits for Motor Planning

    Publication
    The brain plans and executes volitional movements. The underlying patterns of neural population activity have been explored in the context of movements of the eyes, limbs, tongue, and …

  40. Heterogeneity of resting-state EEG features in juvenile myoclonic epilepsy and controls.

    Publication

  41. Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine

    Publication
    Sleep has a complex micro-architecture, encompassing micro-arousals, sleep spindles and transitions between sleep stages. Fragmented sleep impairs memory consolidation, whereas spindle-rich and delta-rich non …

  42. A gradual temporal shift of dopamine responses mirrors the progression of temporal difference error in machine learning

    Publication
    A large body of evidence has indicated that the phasic responses of midbrain dopamine neurons show a remarkable similarity to a type of teaching signal (temporal difference (TD …

  43. A Theoretical Framework for Human and Nonhuman Vocal Interaction

    Publication
    Vocal communication is a critical feature of social interaction across species; however, the relation between such behavior in humans and nonhumans remains unclear. To enable comparative investigation of …

  44. Effect of spin-orbit coupling on the high harmonics from the topological Dirac semimetal Na3Bi

    Publication

  45. Periarteriolar spaces modulate cerebrospinal fluid transport into brain and demonstrate altered morphology in aging and Alzheimer's disease

    Publication
    Perivascular spaces (PVS) drain brain waste metabolites, but their specific flow paths are debated. Meningeal pia mater reportedly forms the outermost boundary that confines flow around blood vessels …

  46. A transcriptomic axis predicts state modulation of cortical interneurons

    Publication
    Transcriptomics has revealed that cortical inhibitory neurons exhibit a great diversity of fine molecular subtypes1-6, but it is not known whether these subtypes have correspondingly diverse patterns …

  47. A call for more clarity around causality in neuroscience

    Publication
    In neuroscience, the term 'causality' is used to refer to different concepts, leading to confusion. Here we illustrate some of those variations, and we suggest names for them …

  48. Action suppression reveals opponent parallel control via striatal circuits

    Publication
    The direct and indirect pathways of the basal ganglia are classically thought to promote and suppress action, respectively1. However, the observed co-activation of striatal direct and indirect …