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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Towards Adaptive Simulations of Dispersive Tsunami Propagation from an Asteroid Impact

    Publication
    The long-term goal of this work is the development of high-fidelity simulation tools for dispersive tsunami propagation. A dispersive model is especially important for short wavelength …
  2. Oculomotor plant and neural dynamics suggest gaze control requires integration on distributed timescales

    Publication
    … integrator. Here we use measurements from new and published experiments in the larval zebrafish together with modelling to reconcile recent oculomotor plant observations with oculomotor integrator function …
  3. The longitudinal bidirectional relationship between autistic traits and brain morphology from childhood to adolescence: A population-based cohort study.

    Publication
  4. Bayesian control variates for optimal covariance estimation with pairs of simulations and surrogates

    Publication
    Predictions of the mean and covariance matrix of summary statistics are critical for confronting cosmological theories with observations, not least for likelihood approximations and parameter inference. Accurate estimates …
  5. Integrative analysis prioritised oxytocin-related biomarkers associated with the aetiology of autism spectrum disorder.

    Publication
  6. Bath-induced delocalization in interacting disordered spin chains

    Publication
  7. Terahertz-induced high-order harmonic generation and nonlinear charge transport in graphene

    Publication
  8. Electronic structure of the highly conductive perovskite oxide SrMoO

    Publication
  9. A set of hub neurons and non-local connectivity features support global brain dynamics in C. elegans

    Publication
    The wiring architecture of neuronal networks is assumed to be a strong determinant of their dynamical computations. An ongoing effort in neuroscience is therefore to generate comprehensive synapse …
  10. Telehealth diagnosis of autism spectrum disorder through clinical cases.

    Publication
  11. Association of mitochondrial DNA content, heteroplasmies and inter-generational transmission with autism.

    Publication
  12. Characterization of phenotypic range in DYRK1A haploinsufficiency syndrome using standardized behavioral measures.

    Publication
  13. Age-related central gain with degraded neural synchrony in the auditory brainstem of mice and humans.

    Publication
  14. Controlling for spurious nonlinear dependence in connectivity analyses.

    Publication
  15. Subgrouping school-aged children with autism spectrum disorder based on co-occurring psychopathology.

    Publication
  16. Co-occurring attention-deficit/hyperactivity disorder and anxiety disorders differentially affect males and females with autism.

    Publication
  17. The early start Denver model intervention and Mu rhythm attenuation in autism spectrum disorders.

    Publication
  18. The Atacama Cosmology Telescope: Constraints on Pre-Recombination Early Dark Energy

    Publication
    The early dark energy (EDE) scenario aims to increase the value of the Hubble constant (H0) inferred from cosmic microwave background (CMB) data over that found in ΛCDM …
  19. The 3D Galactocentric Velocities of Kepler Stars: Marginalizing Over Missing Radial Velocities

    Publication
    Precise Gaia measurements of positions, parallaxes, and proper motions provide an opportunity to calculate 3D positions and 2D velocities (i.e., 5D phase-space) of Milky Way stars …
  20. Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease.

    Publication
  21. Bumpy Declining Light Curves Are Common in Hydrogen-poor Superluminous Supernovae

    Publication
    Recent work has revealed that the light curves of hydrogen-poor (Type I) superluminous supernovae (SLSNe), thought to be powered by magnetar central engines, do not always follow …
  22. Surface plasmons induce topological transition in graphene/α-MoO

    Publication
  23. Consistency of parent-report SLC6A1 data in Simons Searchlight with provider-based publications.

    Publication
  24. Constraining the Planet Occurrence Rate around Halo Stars of Potentially Extragalactic Origin

    Publication
    The search for planets orbiting other stars has recently expanded to include stars from galaxies outside the Milky Way. With the TESS and Gaia surveys, photometric and kinematic …
  25. Freezing revisited: coordinated autonomic and central optimization of threat coping

    Publication
    Animals have sophisticated mechanisms for coping with danger. Freezing is a unique state that, upon threat detection, allows evidence to be gathered, response possibilities to be previsioned and …
  26. Autism NPCs from both idiopathic and CNV 16p11.2 deletion patients exhibit dysregulation of proliferation and mitogenic responses.

    Publication
  27. Self-organized flows in phase-synchronizing active fluids

    Publication
    Many active biological particles, such as swimming microorganisms or motor-proteins, do work on their environment by going though a periodic sequence of shapes. Interactions between particles can …
  28. Calculating genetic risk for dysfunction in pleiotropic biological processes using whole exome sequencing data.

    Publication
  29. Fate mapping of neural stem cell niches reveals distinct origins of human cortical astrocytes.

    Publication
  30. High Performance Equilibrium Solvers for Integrated Magnetic Fusion Simulations

    Publication
    … magnets. As such, they may become more desirable than steady-state tokamak reactors for cost efficient electricity generation.
  31. Reliability and limitations of inferring birth radii in the Milky Way disc

    Publication
    Recovering the birth radii of observed stars in the Milky Way is one of the ultimate goals of Galactic Archaeology. One method to infer the birth radius and …
  32. A stable, efficient scheme for \({C}^n\) function extensions on smooth domains in \({R}^d\)

    Publication
    A new scheme is proposed to construct a \(mathcal{C}^n\) function extension for smooth functions defined on a smooth domain \(Din mathbb{R}^d\). Unlike the PUX …
  33. Gradient-based learning drives robust representations in recurrent neural networks by balancing compression and expansion

    Publication
    Neural networks need the right representations of input data to learn. Here we ask how gradient-based learning shapes a fundamental property of representations in recurrent neural networks …
  34. Boundaries of chaos and determinism in the cosmos

    Publication
    According to the standard model of cosmology, the arrangement of matter in the cosmos on scales much larger than galaxies is entirely specified by the initial conditions laid …
  35. Angular Momentum Transport in Proto-Neutron Stars and the Fate of Neutron Star Merger Remnants

    Publication
    Both the core collapse of rotating massive stars, and the coalescence of neutron star (NS) binaries, result in the formation of a hot, differentially rotating NS remnant. The …
  36. Towards a more general understanding of the algorithmic utility of recurrent connections

    Publication
    Lateral and recurrent connections are ubiquitous in biological neural circuits. Yet while the strong computational abilities of feedforward networks have been extensively studied, our understanding of the role …
  37. Biophysical Kv3 channel alterations dampen excitability of cortical PV interneurons and contribute to network hyperexcitability in early Alzheimer's.

    Publication
  38. A Statistical Linear Precoding Scheme Based on Random Iterative Method for Massive MIMO Systems

    Publication
    In this paper, the random iterative method is introduced to massive multiple-input multiple-output (MIMO) systems for the efficient downlink linear precoding. By adopting the random sampling …
  39. Recurrent Connections in the Primate Ventral Visual Stream Mediate a Trade-Off Between Task Performance and Network Size During Core Object Recognition

    Publication
    The computational role of the abundant feedback connections in the ventral visual stream is unclear, enabling humans and nonhuman primates to effortlessly recognize objects across a multitude of …
  40. Opposite expression patterns of Spry3 and p75NTR in cerebellar vermis suggest a male-specific mechanism of autism pathogenesis.

    Publication
  41. Unraveling protein dynamics to understand the brain - the next molecular frontier

    Publication
    The technological revolution to measure global gene expression at the single-cell level is currently transforming our knowledge of the brain and neurological diseases, leading from a basic …
  42. Bursting Bubbles: Feedback from Clustered Supernovae and the Trade-off Between Turbulence and Outflows

    Publication
    We present an analytic model for clustered supernovae (SNe) feedback in galaxy disks, incorporating the dynamical evolution of superbubbles formed from spatially overlapping SNe remnants. We propose two …
  43. Measuring biological age using omics data

    Publication
    Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-related diseases and increase healthspan have suggested targeting the ageing process …
  44. Multiple timescales of sensory-evidence accumulation across the dorsal cortex

    Publication
    Cortical areas seem to form a hierarchy of intrinsic timescales, but the relevance of this organization for cognitive behavior remains unknown. In particular, decisions requiring the gradual accrual …
  45. Disrupted computations of social control in individuals with obsessive-compulsive and misophonia symptoms.

    Publication
  46. SFARI genes and where to find them; modelling autism spectrum disorder specific gene expression dysregulation with RNA-seq data.

    Publication
  47. Deficiency of autism-related Scn2a gene in mice disrupts sleep patterns and circadian rhythms.

    Publication
  48. A Bayesian Population Model for the Observed Dust Attenuation in Galaxies

    Publication
    Dust plays a pivotal role in determining the observed spectral energy distribution (SED) of galaxies. Yet our understanding of dust attenuation is limited and our observations suffer from …
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