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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Featured

Dissecting mechanisms of hyperarousal in autism and related disorders using the Simons Sleep Project

Funded Work

Gravity Follows Newton’s and Einstein’s Rules, Even at Cosmic Scales

April 15, 2026

Scientists Capture Superconductivity’s ‘Dancing Pairs’ for First Time, Filling Gap in Decades-Old Theory

April 15, 2026

How SURFiN Fellowships Jump-Started These 3 Neuroscience Students’ STEM Careers

March 18, 2026

Results

  1. Emerging principles of spacetime in brains: Meeting report on spatial neurodynamics

    Publication
    How do neurons and networks of neurons interact spatially? Here, we overview recent discoveries revealing how spatial dynamics of spiking and postsynaptic activity efficiently expose and explain fundamental …
  2. Stability selection enables robust learning of differential equations from limited noisy data

    Publication
    We present a statistical learning framework for robust identification of differential equations from noisy spatio-temporal data. We address two issues that have so far limited the application …
  3. Abnormal sensory perception masks behavioral performance of Grin1 knockdown mice.

    Publication
  4. Parallel Discrete Convolutions on Adaptive Particle Representations of Images

    Publication
    We present data structures and algorithms for native implementations of discrete convolution operators over Adaptive Particle Representations (APR) of images on parallel computer architectures. The APR is a …
  5. Simple lessons from complex learning: what a neural network model learns about cosmic structure formation

    Publication
    We train a neural network model to predict the full phase space evolution of cosmological N-body simulations. Its success implies that the neural network model is accurately …
  6. HoloML in Stan: Low-photon Image Reconstruction

    Publication
    This case study is a reimplementation of the algorithm described in Barmherzig and Sun (2022) [1] as a Stan model. This requires the new features available in Stan …
  7. Discrete Lehmann representation of imaginary time Green's functions

    Publication
    We present an efficient basis for imaginary time Green's functions based on a low rank decomposition of the spectral Lehmann representation. The basis functions are simply a …
  8. Dynamic task-belief is an integral part of decision-making

    Publication
    Natural decisions involve two seemingly separable processes: inferring the relevant task (task-belief) and performing the believed-relevant task. The assumed separability has led to the traditional practice …
  9. Using child-friendly movie stimuli to study the development of face, place, and object regions from age 3 to 12 years.

    Publication
  10. Video-evoked fMRI BOLD responses are highly consistent across different data acquisition sites.

    Publication
  11. Clinical autism subscales have common genetic liabilities that are heritable, pleiotropic, and generalizable to the general population.

    Publication
  12. Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder.

    Publication
  13. Excess ribosomal protein production unbalances translation in a model of fragile X syndrome.

    Publication
  14. Efficient coding of cognitive variables underlies dopamine response and choice behavior

    Publication
    Reward expectations based on internal knowledge of the external environment are a core component of adaptive behavior. However, internal knowledge may be inaccurate or incomplete due to errors …
  15. Stable choice coding in rat frontal orienting fields across model-predicted changes of mind

    Publication
    During decision making in a changing environment, evidence that may guide the decision accumulates until the point of action. In the rat, provisional choice is thought to be …
  16. Association between resting-state functional brain connectivity and gene expression is altered in autism spectrum disorder.

    Publication
  17. Field Level Neural Network Emulator for Cosmological N-body Simulations

    Publication
    We build a field level emulator for cosmic structure formation that is accurate in the nonlinear regime. Our emulator consists of two convolutional neural networks trained to output …
  18. The female protective effect against autism spectrum disorder.

    Publication
  19. Randomized Iterative Methods for Low-Complexity Large-Scale MIMO Detection

    Publication
    In this paper, we introduce a randomized iterative method for signal detection in uplink large-scale multiple-input multiple-output (MIMO) systems, which not only achieves a low …
  20. A reference tissue atlas for the human kidney

    Publication
    Kidney Precision Medicine Project (KPMP) is building a spatially specified human kidney tissue atlas in health and disease with single-cell resolution. Here, we describe the construction of …
  21. Dynamic causal communication channels between neocortical areas

    Publication
    Processing of sensory information depends on the interactions between hierarchically connected neocortical regions, but it remains unclear how the activity in one area causally influences the activity dynamics …
  22. Perivascular pumping in the mouse brain: Improved boundary conditions reconcile theory, simulation, and experiment

    Publication
    Cerebrospinal fluid (CSF) flows through the perivascular spaces (PVSs) surrounding cerebral arteries. Revealing the mechanisms driving that flow could bring improved understanding of brain waste transport and insights …
  23. Creation and evaluation of full-text literature-derived, feature-weighted disease models of genetically determined developmental disorders.

    Publication
  24. Analytic Light Curves in Reflected Light: Phase Curves, Occultations, and Non-Lambertian Scattering for Spherical Planets and Moons

    Publication
    We derive efficient, closed-form, differentiable, and numerically stable solutions for the flux measured from a spherical planet or moon seen in reflected light, either in or out …
  25. The In Situ Origins of Dwarf Stellar Outskirts in FIRE-2

    Publication
    Extended, old, and round stellar halos appear to be ubiquitous around high-mass dwarf galaxies (108.5 < M⋆/M⊙ < 109.6) in the observed universe. However, it is …
  26. The chemical enrichment of the Milky Way disk evaluated using conditional abundances

    Publication
    Chemical abundances of stars in the Milky Way disk are empirical tracers of its enrichment history. However, they capture joint-information that is valuable to disentangle. In this …
  27. A general decoding strategy explains the relationship between behavior and correlated variability

    Publication
    Improvements in perception are frequently accompanied by decreases in correlated variability in sensory cortex. This relationship is puzzling because overall changes in correlated variability should minimally affect optimal …
  28. Conserved circuits for direction selectivity in the primate retina

    Publication
    The detection of motion direction is a fundamental visual function and a classic model for neural computation. In the non-primate retina, direction selectivity arises in starburst amacrine …
  29. All-sky, all-frequency directional search for persistent gravitational-waves from Advanced LIGO's and Advanced Virgo's first three observing runs

    Publication
    We present the first results from an all-sky all-frequency (ASAF) search for an anisotropic stochastic gravitational-wave background using the data from the first three observing …
  30. Cosmological Information in the Marked Power Spectrum of the Galaxy Field

    Publication
    Marked power spectra are two-point statistics of a marked field obtained by weighting each location with a function that depends on the local density around that point …
  31. Constraining the length and pattern speed of the Milky Way bar from direct orbit integration of APOGEE and Gaia data

    Publication
    The dynamics of the inner Galaxy contain crucial clues for untangling the evolutionary history of the Milky Way. However, the inner Galaxy's gravitational potential is poorly constrained …
  32. Learning binds new inputs into functional synaptic clusters via spinogenesis

    Publication
    Learning induces the formation of new excitatory synapses in the form of dendritic spines, but their functional properties remain unknown. Here, using longitudinal in vivo two-photon imaging …
  33. Learning the Architectural Features That Predict Functional Similarity of Neural Networks

    Publication
    The mapping of the wiring diagrams of neural circuits promises to allow us to link the structure and function of neural networks. Current approaches to analyzing such connectomes …
  34. Peripheral auditory nerve impairment in a mouse model of syndromic autism.

    Publication
  35. Contrastive machine learning reveals the structure of neuroanatomical variation within autism.

    Publication
  36. Internally generated population activity in cortical networks hinders information transmission

    Publication
    How neuronal variability affects sensory coding is a central question in systems neuroscience, often with complex and model-dependent answers. Many studies explore population models with a parametric …
  37. Cosmological Information in the Marked Power Spectrum of the Galaxy Field

    Publication
    Marked power spectra are two-point statistics of a marked field obtained by weighting each location with a function that depends on the local density around that point …
  38. Learning binds new inputs into functional synaptic clusters via spinogenesis

    Publication
    Learning induces the formation of new excitatory synapses in the form of dendritic spines, but their functional properties remain unknown. Here, using longitudinal in vivo two-photon imaging …
  39. Ankyrin-B is lipid-modified by S-palmitoylation to promote dendritic membrane scaffolding of voltage-gated sodium channel Nav1.2 in neurons.

    Publication
  40. DeepND: Deep multitask learning of gene risk for comorbid neurodevelopmental disorders.

    Publication
  41. Discrete Lehmann representation of imaginary time Green's functions

    Publication
  42. Unconventional excitonic states with phonon sidebands in layered silicon diphosphide

    Publication
  43. Ab Initio Cluster Approach for High Harmonic Generation in Liquids

    Publication
  44. Trigonal symmetry breaking and its electronic effects in the two-dimensional dihalides MX

    Publication
  45. Probing phonon dynamics with multidimensional high harmonic carrier-envelope-phase spectroscopy

    Publication
  46. Strongly correlated electron--photon systems

    Publication
  47. Molecular Characterization of Membranous Nephropathy

    Publication
    Although membranous nephropathy (MN) is one of the most common causes of nephrotic syndrome, the molecular characteristics of the kidney damage in MN remain poorly defined. In this …
  48. A neural mechanism for detecting object motion during self-motion

    Publication
    Detection of objects that move in a scene is a fundamental computation performed by the visual system. This computation is greatly complicated by observer motion, which causes most …
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